Co-Amoxi 1.2gm Injection 1 vial

Co-Amoxi 1.2gm Injection 1 vial is prescribed to treat various bacterial infections 

Co-Amoxi 1.2gm Injection 1 vial contains amoxicillin and clavulanic acid 

Co-Amoxi 1.2gm Injection 1 vial is administered into the patient’s veins by a healthcare professional (eg,nurse)

1.2gm of Co-Amoxi 1.2gm Injection 1 vial comes packaged in a glass vial.Each vial is sold separately.

Co-Amoxi 1.2gm Injection 1 vial is prescribed to adults and childrens aswell

Categories: , , , , , , ,
Type

Injection

Feature

1.2gm

Unit

vial

Formula

Co-amoxiclav

Composition

Co-amoxiclav 1.2 gm

Brand

Macter Pharma

Prescription Required

Yes

How to use, Side effects, Uses, Formula & Composition

ABOUT

Co-Amoxi 1.2gm Injection 1 vial belongs to a class of drugs called “beta-lactamase inhibitors” (broad-spectrum antibiotics). It is a combination antibiotic used to fight antibacterial infections. 

Co-Amoxi 1.2gm Injection 1 vial contains amoxicillin (an antibiotic from the penicillin group of medicines that works by preventing the formation of the protective bacterial wall, essential for the survival of the bacteria) mixed with clavulanic acid (a beta-lactamase inhibitor that reduces resistance and enhances the activity of amoxicillin by preventing bacteria from breaking it down), allowing the antibiotic to work better and up to its full efficacy.  

It is available on prescription, as tablets, in liquid form, and as an injection, usually only given in the hospital. Co-Amoxi 1.2gm Injection 1 vial is best prescribed for short-term treatment of bacterial infections of the respiratory tract, Genito-urinary tract, skin, bone, and tooth among others.

Common side effects of this medication are nausea, vomiting, diarrhea, and thrush. 

Dosage of Co-Amoxi 1.2gm Injection 1 vial depends on age, the severity of the condition, the patient’s response to the medicine, and their comorbidities. In children, it is also based on their weight. 

Indications

It is used in the treatment of:

  • Infections of the respiratory tract (nose, throat, larynx, trachea, bronchi, and lungs)
  • ENT (eyes, nose, and throat) infections
  • Urinary tract infections
  • Skin and soft tissue infections.
  • Dental infections
  • Joint and bone infections

How does Co-Amoxi 1.2gm Injection 1 vial work?

It is a beta-lactamase inhibitor (broad-spectrum antibiotic) containing amoxicillin (an antibiotic from the penicillin group of medicines that works by preventing the formation of the protective bacterial wall, essential for the survival of the bacteria) mixed with clavulanic acid (a beta-lactamase inhibitor which reduces resistance and enhances the activity of amoxicillin by preventing bacteria from breaking it down), allowing the antibiotic to work better and up to its full efficacy.  

How to use Co-Amoxi 1.2gm Injection 1 vial?

Co-Amoxi 1.2gm Injection 1 vial is given intravenously exclusively in dosage (usually  6 to 8 hourly) depending upon the severity of infection and kidney function. Co-Amoxi 1.2gm Injection 1 vial must not be used without a doctor’s advice to avoid bacterial resistance. You will probably be prescribed to take it for 5-14 days.

Co-Amoxi 1.2gm Injection 1 vial needs to be prepared into a solution form by the addition of sterile water/diluent into the powdered medicine. Read the instructions on the label carefully. For preparing 1.2 g of injection (1000 mg/ 200 mg) add 20 ml of solvent available with the package. For slow IV infusion via drip add 100 ml of infusion fluid to Co-Amoxi 1.2gm Injection 1 vial to form the antibiotic solution. After dilution, the solution must be used immediately in a single dose and the leftover should be discarded. 

Dosage Forms and Potency

Dosage is completely dependent on the weight, age, severity of infection, patient’s response to the medicine, and their comorbidities. Your doctor may vary your dosage accordingly. A new, sterile syringe must always be used and properly discarded following universal protocol for sharps disposal. Co-Amoxi 1.2gm Injection 1 vial is available in the following potency:

  • 1.2 gram          IV

(1grams of amoxicillin sodium / 200 mg of Clavulanic Acid powder)

Co-Amoxi 1.2gm Injection 1 vial is strictly meant for intravenous use, which can be given via quick Intravenous infusion (3-5 minutes) or slow infusion over 30 to 40 minutes. IV antibiotics can be administered in a healthcare facility or at home a visiting nurse can be appointed to give you the medication.

It can also be diluted with other injectable solutions matching the compatibility with Co-Amoxi 1.2gm Injection 1 vial other than calcium products, such as sodium chloride solution, ringer’s lactate, etc. When using at home make sure you understand the correct ratio and method of diluting the Co-Amoxi 1.2gm Injection 1 vial. A healthcare provider can help you maintain IV lines at home. 

Dosage

Following doses are commonly prescribed to treat an ongoing infection:

Adult Dosage:

Mild to moderate infections: 1.2 grams IV,  three times a day at an interval of 8 hours

Severe Infection:  1.2 grams,  four times a day at an interval of 6 hours

Surgical Prophylaxis: 1.2 grams IV 30 minutes before the operation or at the time of anesthesia. Followed by 8 hourly doses in patients with a high risk of developing an infection

Pediatric Dosage:

12 years and above: 1.2 grams IV,  three times a day at an interval of 8 hours (or four times at 6 hourly intervals in cases of severe infection)

 3 months – 12 years: 30 mg/kg IV  three times a day at an interval of 8 hours (or four times at 6 hourly intervals in cases of severe infection)

0 to  3 months: 30 mg/kg IV  two times a day at an interval of 12 hours (or three times at 8 hourly intervals in cases of severe infection)

Elderly Dosage:

Doses must be adjusted keeping in mind comorbidities. Moreover, Co-Amoxi 1.2gm Injection 1 vial is excreted mostly by the kidney, therefore while administering the drug to elderly patients (65 years and above) careful consideration must be given to renal function while deciding upon the dose. 

*Special Dosage

Kidney Impairment: Dose Adjustment required (as per creatinine clearance values)

Liver Inadequacy: Dose Adjustment required

Pregnancy use and lactation

If you are pregnant, think you may be pregnant, or are planning to have a baby, please consult your doctor before using Co-Amoxi 1.2gm Injection 1 vial.

If you are breastfeeding, please consult your doctor before taking Co-Amoxi 1.2gm Injection 1 vial. 

Contraindications

Please inform your doctor if you have a history of any before using Co-Amoxi 1.2gm Injection 1 vial:

  • Penicillin hypersensitivity (allergy) – allergic reaction indicated by skin rash, swelling around the face area, wheezing, chest tightness, and breathing difficulty
  • History of Co-Amoxi 1.2gm Injection 1 vial associated or penicillin associated jaundice or hepatic (liver) dysfunction.
  • If you have or think you may have glandular fever
  • Liver problems
  • Kidney problems
  • Not passing urine regularly
  • Liquid form is not suitable for people with a rare inherited condition called phenylketonuria as it may contain aspartame which may be harmful to you. 

Precautions

Please tell your doctor about any of the following conditions while using Co-Amoxi 1.2gm Injection 1 vial:

  • Renal (kidney) impairment – monitor kidney function
  • Hepatic (liver) impairment – monitor liver function
  • Risk of crystalluria (cloudy urine) with high doses, patients should be well hydrated. Do not dilute syrup below half-strength
  • Renal impairment (kidney damage)
  • Infectious mononucleosis (glandular fever caused by EBV)
  • Risk of acute generalized exanthematous pustulosis (inflammatory skin condition resulting in large fluid-filled blister-like areas) – in such a case, discontinue permanently.

Interaction with other medications

Certain medications could interact with Co-Amoxi 1.2gm Injection 1 vial, hence, in that case, your doctor might alter your dosage and make sure to monitor blood sugar levels more closely.

Please inform your doctor about the use of the following before taking Co-Amoxi 1.2gm Injection 1 vial:

  • Anticoagulants such as warfarin
  • Allopurinol and probenecid (used to treat gout)
  • Oral contraceptives
  • Methotrexate (used to treat cancer or rheumatic diseases)
  • Mycophenolate mofetil (used to prevent the rejection of transplanted organs
  • Positive Coombs test.

Adverse effects

Like most medicines, Co-Amoxi 1.2gm Injection 1 vial has some side effects which include:

Common

  • Nausea 
  • Vomiting 
  • Diarrhea 
  • Thrush

Serious

Hypersensitivity/allergic skin reactions; in this case discontinue 

  • Hepatitis (inflamed or infected liver)
  • Cholestatic jaundice (jaundice due to reduced bile flow)
  • Erythema multiforme (including Stevens-Johnson syndrome) (inflammatory skin reaction to infection or some medicines)
  • Toxic epidermal necrolysis (severe skin reaction)
  • Exfoliative dermatitis (redness and peeling of the skin over large areas of the body)
  • Vasculitis (inflamed blood vessels)
  • Rarely prolongation of bleeding time
  • Dizziness
  • Headache
  • Convulsions-fits (particularly with high doses or in kidney impairment)
  • Superficial staining of teeth with suspension
  • Phlebitis at the injection site
  • Blood dyscrasias (disorders)
  • CNS (brain-related) effects
  • Antibiotic-associated colitis (inflamed large intestine)

How to cope with some of the adverse effects

  • Soreness at the site of injection- a cold compress can be used for 5 minutes to ease out the soreness.
  • Skin Rash- can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash helps reduce itchiness and redness caused by the rash. An antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.
  • Nausea (feeling sick) Take Co-Amoxi 1.2gm Injection 1 vial with meals to avoid feeling sick.
  • Vomiting/Diarrhea – Keep yourself hydrated by having lots of fluids and if the problem persists, consult your doctor before taking any medication for vomiting and diarrhea
  • Thrush – Inform your doctor and ask for advice about what to do. 

Inform your doctor immediately if you experience any serious side effects.

FAQs

#1. WHAT EXACTLY DOES Co-Amoxi 1.2gm Injection 1 vial DO?

It is a beta-lactamase inhibitor (broad-spectrum antibiotic) containing amoxicillin (an antibiotic from the penicillin group of medicines that works by preventing the formation of the protective bacterial wall, essential for the survival of the bacteria) mixed with clavulanic acid (a beta-lactamase inhibitor which reduces resistance and enhances the activity of amoxicillin by preventing bacteria from breaking it down), allowing the antibiotic to work better and up to its full efficacy.

#2. HOW LONG DOES IT TAKE FOR Co-Amoxi 1.2gm Injection 1 vial TO START WORKING?

After taking Co-Amoxi 1.2gm Injection 1 vial you will start to feel better in a few days. 

#3. HOW LONG WILL I HAVE TO TAKE Co-Amoxi 1.2gm Injection 1 vial FOR?

The duration for using Co-Amoxi 1.2gm Injection 1 vial depends on the type and severity of the infection. You will probably be prescribed to take it for 5-14 days. If you do not feel better after completing your course of medicine, or if you feel worse at any time, contact your doctor.

#4. CAN I STOP TAKING Co-Amoxi 1.2gm Injection 1 vial?

Do not just stop taking the medicine, make sure to complete your treatment course even if you feel better. Stopping it suddenly may cause the bacteria to start multiplying again and the infection could come back. The bacteria could also develop resistance to the antibiotic which will make it ineffective in the future.

#5. CAN I DRINK ALCOHOL WITH Co-Amoxi 1.2gm Injection 1 vial?

Consuming alcohol when taking Co-Amoxi 1.2gm Injection 1 vial is not known to cause any severe problems but if you are already feeling sick as a side effect of Co-Amoxi 1.2gm Injection 1 vial, it might make it worse. 

#6. WHAT IF I TAKE TOO MUCH OF Co-Amoxi 1.2gm Injection 1 vial?

If you have taken one extra dose of Co-Amoxi 1.2gm Injection 1 vial it is unlikely to harm, you. Side effects of taking Co-Amoxi 1.2gm Injection 1 vial more than the prescribed dose are upset stomach, nausea, vomiting, diarrhea, and (seizure) fits. Contact your doctor immediately if you have taken 2 or more doses and experience any serious symptoms. 

#7. WHAT IF I FORGET TO TAKE Co-Amoxi 1.2gm Injection 1 vial?

It is administered by a healthcare professional in a hospital so there is a rare chance you will miss a dose. In case you miss a dose, ask for your next dose on time, and do not try making up for the missed dose by doubling it up. If it helps to remind you, set an alarm so you do not miss any dose. Make sure to complete your course of treatment even if you feel better and think you do not need to take it anymore.

#8. CAN I TAKE Co-Amoxi 1.2gm Injection 1 vial DURING PREGNANCY OR BREASTFEEDING?

If you are pregnant, think you may be pregnant, or are planning to have a baby, please consult your doctor before using Co-Amoxi 1.2gm Injection 1 vial.

If you are breastfeeding, please consult your doctor before taking Co-Amoxi 1.2gm Injection 1 vial.

#9. IS IT SAFE TO USE Co-Amoxi 1.2gm Injection 1 vial FOR A LONG TIME?

Co-Amoxi 1.2gm Injection 1 vial is usually generally recommended for 5-14 days, therefore, do not take it for any longer than the prescribed period. 

#10. CAN I DRIVE OR RIDE A BIKE AFTER TAKING Co-Amoxi 1.2gm Injection 1 vial?

Make sure you know how your body reacts while using ‘product’ as it is known to make you feel dizzy. Do not drive or use any machinery until you feel normal again

#11. HOW SHOULD Co-Amoxi 1.2gm Injection 1 vial BE STORED?

Keep the medicine tightly closed in the packet it came in. Store it at room temperature, away from excess heat and moisture. Do not freeze the liquid form of the medication. Make sure it is not consumed by pets, children, and other people. Dispose of the unused medicine.