Dilozen 600mg Tablet 6 ‘S

Description

About

Dilozen 600mg Tablet 6 ‘S is a synthetic antibiotic that is used to treat infections caused by aerobic Gram-positive bacteria. It is bacteriostatic against both enterococci and staphylococci, as well as bactericidal against most streptococci isolates. This medicine is prescribed to treat some types of severe bacterial infections such as pneumonia, and skin and soft tissue infections. This medicine is only active against diseases caused by gram-positive organisms and is inactive against gram-negative disease-causing pathogens.

Dilozen 600mg Tablet 6 ‘S belongs to a class of drugs known as monoamine oxidase (MAO) inhibitors that work by interfering with the growth of bacteria. Colds, flu, and other viral diseases do not respond to antibiotics such as Dilozen 600mg Tablet 6 ‘S. When antibiotics are used when they aren’t needed, you run the risk of developing an infection that is resistant to antibiotics later. 

Dilozen 600mg Tablet 6 ‘S is available on prescription as tablets to be taken by mouth (orally) usually twice a day or as directed by your doctor. 

Common side effects of this medication are nausea, vomiting, abdominal pain, anemia, loose stools, eosinophilia, etc.

Dosage is largely determined by the patient’s reaction to the product as well as any side effects seen during therapy. Dosage should not be raised or decreased without consulting a physician, and the product should only be used for the period prescribed.

Indications

Dilozen 600mg Tablet 6 ‘S is used in the treatment of:

• Nosocomial pneumonia caused by streptococcus pneumonia and staphylococcus aureus (methicilin resistant and susceptible isolates)
• Community-acquired pneumonia caused by streptococcus pneumonia and staphylococcus aureus (methicilin resistant and susceptible isolates)
• Infections of the skin and skin structures, both complicated and uncomplicated, such as diabetic foot infections 
• Vancomycin-resistant Enterococcus faecium infections.

How Does Dilozen 600mg Tablet 6 ‘S Work?

Dilozen 600mg Tablet 6 ‘S contains Linezolid as an active ingredient. Linezolid is an antibiotic oxazolidinone that is effective against most aerobic Gram-positive bacteria and mycobacteria. It seems to be bacteriostatic against staphylococci and enterococci, as well as bactericidal against most streptococci isolates. 

Linezolid works as an antibacterial agent by interfering with the translation of bacterial proteins. It binds to a location on the 50S subunit of the bacterial 23S ribosomal RNA, blocking the creation of a functional 70S initiation complex, which is required for bacterial reproduction and hence prevents bacteria from dividing.

How to use Dilozen 600mg Tablet 6 ‘S?

Dilozen 600mg Tablet 6 ‘S is available as a tablet and suspension. This medication is taken by mouth with or without food usually two times a day (every 12hrs) for 10-28 days or as directed by your physician.

• Your treatment time is determined by the type of illness you have. 
• Follow the directions on your prescription label carefully, and if you have any questions, ask your doctor or pharmacist to clarify anything you don’t understand.
• Take Dilozen 600mg Tablet 6 ‘S exactly as prescribed by your doctor. Do not take more or less of it, or take it more frequently than your doctor prescribes. 
• Even if you feel better, continue taking this medicine until the prescription is finished.
• Do not discontinue taking Dilozen 600mg Tablet 6 ‘S without first consulting your physician. Your illness may not be entirely treated if you stop taking this antibiotic too soon or miss doses, and the bacteria may become resistant to medications. 

Dosage

Form and strength

Capsule

• 100mg (12S)
• 400mg (12S)
• 600mg (12S)

Adult dosage

1. Nosocomial pneumonia: 600mg twice daily for 10-14 consecutive days
2. Community-acquired pneumonia: 600mg twice daily for 10-14 consecutive days
3. Complicated skin and soft tissue infections:  600mg twice daily for 10-14 consecutive days

Child Dosage

Children 12 years of age and younger: 10mg/kg with or without food (every 8 hours) for 10 to 28 days.

Children 12 years of age and older: 600mg with or without food (every 12 hours) for 10 to 28 days.

Elderly dosage

There is no need to modify the dose. 

Age 65years and older – In general, dose adjustments are not necessary for the elderly. The physician, on the other hand, should assess the patient’s potential for organic deterioration and determine the most appropriate dose in each case. 

Pregnancy and Lactation

Dilozen 600mg Tablet 6 ‘S should only be used during pregnancy if it is required, that is if the speculative danger outweighs the potential benefit. 

Breast-feeding should be stopped before and throughout the administration of this drug since it may enter into breast milk. 

Contraindications

Before using Dilozen 600mg Tablet 6 ‘S, consult your doctor if you have a medical history of any of the following:

• Allergic/hypersensitive to Dilozen 600mg Tablet 6 ‘S and its contents, or any food product (such as pork, beef, etc)
• High blood pressure (hypertension)
• Blood/bone marrow problems (such as low red/white blood cells and platelets)
• Certain types of tumors (such as carcinoid syndrome, and pheochromocytoma) 
• Overactive thyroid gland
• History of fit or seizures
• Pregnancy and breastfeeding
• Schizophrenia or bipolar depression

Precautions

Please tell your doctor about any of the following conditions before using {{product}:

• This medication can raise the levels of some natural compounds in the body (such as dopamine, norepinephrine, and serotonin), which can lead to unwanted side effects and drug interactions. 
• When used in combination with serotonergic medications such as selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants, linezolid is a reversible and non-selective inhibitor of monoamine oxidase (MAO) enzymes, which can contribute to the development of serotonin syndrome (TCAs). 
• In patients who develop or have worsening myelosuppression, monitor for myelosuppression and consider stopping the medication. 
• If diarrhea arises, check for Clostridium difficile. 
• Low blood sugar (hypoglycemia) may occur, and blood glucose levels should be monitored. 
• Lactic acidosis has been recorded with the use of this medicine, individuals who develop repeated inexplicable acidosis with nausea and vomiting should be evaluated immediately.
• Peripheral and optic neuropathy have been recorded, particularly in patients who have had long-term therapy (more than 28 days). 
• Avoid taking alcoholic beverages.

Interactions With Other Medications

Consult your doctor about the use of the following medicines before using Dilozen 600mg Tablet 6 ‘S:

• Diethylpropion
• Methylphenidate
• Atomoxetine
• Apraclonidine
• Maprotiline
• Methyldopa
• Buspirone
• Entacapone
• Tryptophan
• Tetrabenazine
• amitryptiline

This document does not contain all probable drug reactions, it is advisable to keep a list of medicines in use and discuss it with your doctor ( this includes prescription/nonprescription and herbal products). 

Adverse Effects

Rare Adverse Effects

Because Dilozen 600mg Tablet 6 ‘S may induce serious and fatal infusion responses followed by cardiac collapse, the following side effects may require rapid attention and report to your doctor:

Serious side effects

• Nausea and vomiting that isn’t going away
• Unusual drowsiness
• Deep/fast breathing
• Numbness/tingling of hands and feet
• Easy bruising and bleeding
• Unusual tiredness

Very serious side effects

• Increased sweating
• Muscle stiffness
• Vision changes such as blurred vision, loss of vision, changes in color vision
• Mental and mood changes such as agitation and confusion
• Seizure
• Clostridium difficile associated diarrhea (with symptoms such as diarrhea that doesn’t stop, mucus or blood in stool, abdominal pain, or cramping)
• Serotonin syndrome or toxicity (characterized by increased heartbeat, hallucinations, severe dizziness, lack of coordination, unexplained fever, severe diarrhea, severe nausea or vomiting, muscles twitching, unexplained agitation or restlessness)
• Hypertensive crisis/extreme high blood pressure

Common Adverse Effects

The following side effects may not require immediate medical attention until becomes troublesome:

• Anaemia
• Headache
• Nausea
• Vomiting 
• Diarrhoea
• Rash
• Abdominal pain
• Fungal infection
• Tongue discoloration
• Taste alteration
• Oral thrush
• Vaginal yeast infection

How To Cope With Some Of The Adverse Effects

• Feeling or being sick (nausea or vomiting) or diarrhea –Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water. 
• Change in taste- this tends to go away as soon as the patient stops taking the medicine but while treatment; saltwater with baking soda (half a teaspoon of salt and baking soda in water) rinses and chewing on sugar-free gum can help dissipate the change in taste.
• Blurred vision- This side effect tends to go away on its own in a few days; patients are advised to not operate heavy machinery or drive any motorized vehicles in the meantime.If blurred vision persists, please contact your doctor.
• Headaches-  In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
• Feeling drowsy – If the medication makes you feel drowsy or sleepy, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

Key Facts About Dilozen 600mg Tablet 6 ‘S

• Dilozen 600mg Tablet 6 ‘S belongs to a group of drugs known as monoamine oxidase (MAO) inhibitors.
• Dilozen 600mg Tablet 6 ‘S contains Linezolid as an active ingredient
• The treatment period with this medication is limited to 28 days at the most. 
• Dilozen 600mg Tablet 6 ‘S should only be used in a hospital setting and after consulting with a specialist such as a microbiologist or an infectious disease specialist. 
• The oral typhoid vaccine may be rendered ineffective by this antibiotic. If you are scheduled for any vaccines, make sure the person administering the vaccine is aware that you are taking this medication. 

FAQs

• How to store Dilozen 600mg Tablet 6 ‘S?

Keep Dilozen 600mg Tablet 6 ‘S in a container at room temperature. Protect from heat. Store in a cool, dry location. keep all medications in a secure location and should be kept out of the reach of children and pets.

• What if I take too much of Dilozen 600mg Tablet 6 ‘S?

In case of too much consumption by accident, kindly contact your doctor or nearby hospital right away. The amount of medication that can result in severe side effects varies from person to person. An overdose results in slowing down of heart rate and difficulty breathing accompanied by dizziness and fainting spells.

• What if I miss a dose of Dilozen 600mg Tablet 6 ‘S?

If you miss a dose of the medication, make sure you take it as soon as possible on that same day. If you don’t remember you missed the dose until the next dosage time or the next day, do not double the dose and take your medication as per schedule.

• Can Dilozen 600mg Tablet 6 ‘S be used if the patient is having flu symptoms?

Dilozen 600mg Tablet 6 ‘S is not deemed to be effective against viruses as Dilozen 600mg Tablet 6 ‘S is an antibiotic and therefore works on bacteria to eliminate bacterial infections.

• Will Dilozen 600mg Tablet 6 ‘S affect my fertility??

 Yes, there is evidence to suggest that patients experience a decrease in fertility.

• What lab tests will be prescribed while treatment with Dilozen 600mg Tablet 6 ‘S and how often?

Kidney and liver function tests along with blood tests to keep a check on serum potassium levels are advised to be done periodically. It is also advised that patients learn to monitor their blood pressure levels daily from the comfort of their homes and inform their doctor of any changes seen.

• Can Dilozen 600mg Tablet 6 ‘S cause dizziness? if so, how should I manage it?

Yes. It can cause dizziness as one of the most common side effects. If this happens, you should sit or lie down until the symptoms pass. However, please note this is temporary and usually goes away as the treatment continues. It is also advised to avoid the consumption of alcohol during your treatment, as it may worsen the dizziness.

• Can I consume alcohol with Dilozen 600mg Tablet 6 ‘S?

Alcohol is known to make an individual dizzy, thus if taken with the medication may lead to extreme dizziness. It is best to avoid the intake of alcohol during your treatment.

• When using Dilozen 600mg Tablet 6 ‘S, is it safe to drive or operate heavy machinery? 

It may not be safe to drive a car or operate heavy machinery if you feel sleepiness, dizziness, hypotension, or a headache as a side effect of this medication. If the medication makes you drowsy, dizzy or decreases your blood pressure significantly, you should not drive a vehicle. Patients are also advised not to drink alcohol while taking Dilozen 600mg Tablet 6 ‘S because alcohol amplifies sleepiness and adverse effects.

• Can lifestyle changes help me with my condition?

Yes. You can adopt certain healthy lifestyle changes to help with high blood pressure. These include quitting smoking, avoiding alcohol, eating a wholesome diet consisting of fresh vegetables and fruits with the cut down on salt, and incorporating physical activity into your daily routine.

• What dietary instructions are to be followed when using Dilozen 600mg Tablet 6 ‘S?

Continue to eat normally until your doctor tells you to switch to a specific diet.