Gempid 600mg Tablet 10 ‘S

Description

About

Heart disease is the most common reason for fatality around the world, affecting millions of people across the globe. Most cardiac conditions are directly or indirectly associated with the accumulation of fat in the circulatory system. Poor dietary choices and lack of physical activity are the main causes of this excessive build-up. {{Product}} is a hypolipidemic medicine belonging to a class of drugs called, Fibrates used to treat high cholesterol in the blood posing a risk of Pancreatitis and heart conditions. It treats conditions like hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia decreases the amount of bad cholesterol (LDL) in the blood and thereby prevents heart attack, stroke, and other conditions. {{Product}} is used as a final resort in patients following exercise and diet modification without getting any results.

Gempid 600mg Tablet 10 ‘S is chemically composed of Gemfibrozil which works by regulating complex fatty molecules via activation of Peroxisome Proliferator-Activated Receptor alpha. It helps break down high-fat molecules into simpler free fatty acids and stops the liver from removing free fatty acids this in return causes decreased triglyceride formation. Gempid 600mg Tablet 10 ‘S increases the activity of lipoprotein lipase that breaks down triglycerides and decreases its levels in the blood. Secondly, Gempid 600mg Tablet 10 ‘S also aids in reducing Apolipoprotein B in the body, a constituent of “bad cholesterol”. The course of therapy is usually a long one lasting about 2 to 3 months or longer as per need.

Gempid 600mg Tablet 10 ‘S  is available in form of oral tablets to be taken twice a day or as prescribed. It is commonly prescribed to patients to be swallowed with water 30 minutes before a meal. Gempid 600mg Tablet 10 ‘S is to be taken regularly, preferably at the same time each day to help the patient remember their daily dose. The effects of Gempid 600mg Tablet 10 ‘S may be seen steadily, combined with a controlled/healthy diet and some physical exercise. Therefore, it is important not to stop the treatment suddenly. A regular check-up of serum cholesterol and liver markers is advised periodically. It is not considered safe for children under 18 years of age, pregnant females, breastfeeding mothers, and liver dysfunction. The most common side effects observed with Gempid 600mg Tablet 10 ‘S include nausea, vomiting, flatulence, and severe abdominal pain. 

Indications

Gempid 600mg Tablet 10 ‘S is prescribed for the management of :

• Hyperlipidemia (Type IV/V) 
• Type IIb Hyperlipidemia without symptoms of coronary disease
• Hypercholesterolemia 
• Severe hypertriglyceridemia 

How Does Gempid 600mg Tablet 10 ‘S Work

Gempid 600mg Tablet 10 ‘S is chemically composed of Gemfibrozil which works by regulating complex fatty molecules via activation of Peroxisome Proliferator-Activated Receptor alpha. It helps break down high-fat molecules into simpler free fatty acids and stops the liver from removing free fatty acids this in return causes decreased triglyceride formation. Gempid 600mg Tablet 10 ‘S increases the activity of lipoprotein lipase, an enzyme that breaks down triglycerides, and decreases its levels in the blood. Secondly, Gempid 600mg Tablet 10 ‘S also aids in reducing Apolipoprotein B in the body, a constituent of “bad cholesterol”.

How To Use {{Product}}

Gempid 600mg Tablet 10 ‘S is available in form of tablets to be taken orally by swallowing, twice daily, or as directed by the doctor. It is advised to have Gempid 600mg Tablet 10 ‘S with food 30 minutes before to help it perform better in your body. Gempid 600mg Tablet 10 ‘S is taken daily and the patient is advised to take the doses at the same time each day usually at 12 hourly intervals to ensure sustained levels of medicine in the body.

A comprehensive treatment plan is formulated for patients suffering from high cholesterol and heart diseases. Before starting Gempid 600mg Tablet 10 ‘S, dietary modifications must include healthy, balanced, and low salt and fat content. Physical exercise is also incorporated to help reduce lipids in your body. It is important to remember adopting healthy lifestyle changes is key before starting the use of Gempid 600mg Tablet 10 ‘S. 

If you miss a dose of the medication, make sure you take it as soon as possible on that same day. If you don’t remember you forgot the dose until the next dose time or the next day, do not double the dose and take your medication as per schedule. Gempid 600mg Tablet 10 ‘S must be used with caution in patients with liver conditions. 

Available from and potency

Tablet – 600 mg

Dosage

Doses are adjusted as per need, and monitoring of serum LDL, HDL, Total cholesterol, and triglyceride levels are done periodically at 4 to 8 weeks interval before adjustment

Adult Dosage

These doses are generally recommended for the following conditions:

Hypertriglyceridemia / Hypercholesterolemia 

Starting Dose: 900 mg taken orally, twice daily in divided doses (30 minutes before breakfast and evening meal) which can be increased up to 1200 mg as per need

Or 600 mg to be  taken orally, twice daily at 12 hourly intervals (30 minutes before breakfast and evening meal)

Maximum Safe Dose:  1200 mg per day

Child dosage

Gempid 600mg Tablet 10 ‘S is not prescribed to children and adolescents under 18 years of age

Elderly Dosage

Dosage in the elderly population is dependent on several factors. Due to potential harmful effects, caution must be exercised. Discuss with your doctor. 

*Special Dose

If there is mild to moderate kidney dysfunction, treatment must be initiated after checking serum creatinine levels 

Liver dysfunction: Do not use Gempid 600mg Tablet 10 ‘S

Pregnancy Use and Lactation

Gempid 600mg Tablet 10 ‘S is categorized as FDA pregnancy category C which means it should not be taken during pregnancy due to potentially harmful effects on unborn babies. Therefore, if you are pregnant, or are planning to conceive a baby, please do discuss Gempid 600mg Tablet 10 ‘S with your doctor before using it. 

If you are breastfeeding an infant ask your doctor first, for some amount of medicine is secreted into the breast milk. With regards to safety please make sure to consult your doctor first before using it. It will only be prescribed if considered necessary.

Contraindications

Please tell your doctor if you have a history of any of the following before using Gempid 600mg Tablet 10 ‘S:

• Hypersensitivity to Gempid 600mg Tablet 10 ‘S  or similar drugs 
• Severe kidney dysfunction 
• Severe liver inadequacy
• Gall bladder disease/ gallstones  
• Pregnancy 
• Breastfeeding 
• Children or /adolescents younger than 18 years of age 
• History of phototoxicity with fibrates 

Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Gempid 600mg Tablet 10 ‘S:‌ 

• If there is a history of allergy to medicines or products. Carefully read the contents of this product to avoid any future inconvenience 
• Adequacy of kidney functions must be ensured, and dose adjustment is required in case of compromised function. Serum creatinine values must be checked regularly 
• Adequacy of liver functions must be ensured. ALT/AST levels should be checked periodically. In case of severe deranged liver function, Gempid 600mg Tablet 10 ‘S will be discontinued 
• Special care must be taken with  Gempid 600mg Tablet 10 ‘S especially if anti-hyperlipidemic like Statins are being taken concurrently. There is an increased risk of muscular problems like rhabdomyolysis, and weakness. Caution is advised especially if you are a diabetic or elderly 
• Most patients with cardiovascular disease are taking some type of blood thinners, which can cause bleeding problems. Dose adjustment and monitoring of INR/PT are advised with concomitant use of anticoagulants
• An increased risk of gallstones exists with the use of Gempid 600mg Tablet 10 ‘S. If you already have a gallbladder disease you must not use this medicine
• The use of Gempid 600mg Tablet 10 ‘S in pregnant females carries a risk to unborn babies so it must not be used unless considered necessary  
• Before using Gempid 600mg Tablet 10 ‘S reduced thyroid function must be informed to doctor
• Regular monitoring of serum cholesterol, LDL, HDL, Triglycerides, creatinine, and Transaminase is advised
• Before you start taking  Gempid 600mg Tablet 10 ‘S you must start a low-fat and salt-restricted diet as well as exercise
• Alcohol consumption and smoking exacerbate heart conditions, therefore these must be avoided
• If you are using Gempid 600mg Tablet 10 ‘S for 3 months or more without achieving desired results, your doctor will ask you to discontinue taking this drug

Interaction With Other Medicines

Certain medications could interact with Gempid 600mg Tablet 10 ‘S and may increase or decrease its absorption, in which case, your doctor might alter your dosage. A few of these interacting drugs are given below:

• Anticoagulants like coumarin, warfarin
• Cilostazol
• Siponimod 
• Antigout like Colchicine 
• Immunosuppressants like cyclosporine, tacrolimus 
• Anti-diabetics like repaglinide, rosiglitazone  
• HMG Co-A reductase like fluvastatin, lovastatin , rosuvastatin 
• Daptomycin
• Insulin 
• Thiazide diuretics 
• Antihypertensives like Valsartan 
• Selexipag 
• Dasabuvir (Anti-hepatitis)
• Loperamide 
• Montelukast 
• Paclitaxel 
• Enzalutamide 

Adverse Effects

Common Side Effects

• Nausea 
• Headache
• Diarrhea/constipation 
• Vertigo 
• Abdominal pain 
• Flatulence 
• Skin rash 
• Fatigue 

Less Common Side Effects

• Anaphylactic reaction
• Blurred vision 
• Pulmonary embolism  
• Gall bladder stones 
• Pancreatitis 
• Thrombocytopenia 
• Hepatitis/ jaundice  
• Muscle pain 
• Muscular weakness (rhabdomyolysis/myositis)
• Photosensitivity 
• Alopecia 
• Anemia 
• Decreased libido 
• Low energy levels 
• Depression 

List Of How to Deal With Adverse Effects

• Allergic Reactions – Allergic reactions to the drug may be mild to severe or potentially could be life-threatening. If allergy is suspected immediately take anti-allergy (antihistamine) medicine which will stop the mild reaction. If a serious allergic reaction is suspected, rush to the nearby hospital and avoid Gempid 600mg Tablet 10 ‘S and drugs with similar compounds in the future.
• Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
• Feeling sick (nausea or vomiting) or diarrhea – Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water. 
• Feeling dizzy (lightheaded) or weak – If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.
• Muscular Aches and Pains – A hot or cold compress can be placed at the area of discomfort to bring relief; an over-the-counter pain reliever such as paracetamol or ibuprofen can be ingested to bring ease as well. Avoid high-intensity exercise while suffering from muscular pain.
• Skin Rash – Can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash helps reduce itchiness and redness caused by the rash. An antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.
• Fatigue – Patients experiencing this adverse effect are advised to take deep breaths, intake tea or coffee, get a good night’s rest, and not overburden themselves for a few days
• Depression – Patients are asked to go out for daily walks while undergoing treatment with Gempid 600mg Tablet 10 ‘S, indulge in a healthy diet consisting of fresh fruits and vegetables, and surround themselves with good company. These emotions are temporary; patients are advised to reach out to a trained professional if they feel that these negative emotions are disrupting their day-to-day life.
• Photosensitivity – patients are asked to wear sun protective clothing when going outside including gloves and hats, to apply generous amounts of broad-spectrum sunblock along with wearing sunglasses. Patients are advised to do all necessary work after sunset to reduce or eliminate sun exposure while undergoing treatment with Gempid 600mg Tablet 10 ‘S

FAQs

#1. CAN LIFESTYLE CHANGES HELP ME WITH MY CONDITION?

Yes, you can adopt certain healthy lifestyle changes to help with high cholesterol and associated problems. These include quitting smoking, avoiding alcohol, eating a wholesome diet consisting of fresh vegetables and fruits with the cut down on salt, and incorporating physical activity into your daily routine. A low-fat diet should be started first and then add fibrate to the treatment plan to help control your condition.

#2. WHAT EXACTLY DOES Gempid 600mg Tablet 10 ‘S DO?

Gempid 600mg Tablet 10 ‘S acts on certain receptors in your body and activating them helps break down complex fat into simpler ones. It also helps reduce bad cholesterol in the blood and creates energy storage in the body.  Also, it increases the activity of lipoprotein lipase that breaks down triglycerides and decreases its levels in the blood.

#3. WHAT IF I TAKE TOO MUCH OF Gempid 600mg Tablet 10 ‘S?

In case of too much consumption by accident, kindly contact your doctor or nearby hospital straight away. The amount of medication that can result in severe side effects varies from person to person. An overdose results in a disturbance of heart rate and difficulty breathing accompanied by dizziness and fainting spells. 

#4. HOW TO STORE Gempid 600mg Tablet 10 ‘S?

Gempid 600mg Tablet 10 ‘S is to be kept away from the reach of children, in a cool dry place away from direct sunlight and humidity below 25ºC, as that tends to ruin certain drugs.

#5. CAN I CONSUME ALCOHOL WITH Gempid 600mg Tablet 10 ‘S?

Alcohol is also known to strain your heart which if already damaged can create problems. Furthermore, Gempid 600mg Tablet 10 ‘S when taken with alcohol increase the risk of rhabdomyolysis, therefore it should be avoided. 

#6. WHAT IF I FORGET TO TAKE THE Gempid 600mg Tablet 10 ‘S?

It is advised that the drug is taken at the same time each day, and an alarm can be placed to remind patients to take Gempid 600mg Tablet 10 ‘S at the proper time. If the patient misses a dose of Gempid 600mg Tablet 10 ‘S, they should take it immediately but if the time for the next dose of the drug is near then it is beneficial for patients to skip the missed dose and take the tablets as per schedule, doubling of doses has proven to cause severe side effects. 

#7. CAN Gempid 600mg Tablet 10 ‘S CAUSE DIZZINESS? IF SO, HOW SHOULD I MANAGE IT?

Yes, it can cause dizziness sometimes as one of the side effects. If this happens, you should sit or lie down until the symptoms pass. However, please note this is temporary and usually goes away as the treatment continues. It is also advised to avoid the consumption of alcohol during your treatment, as it may worsen the dizziness.

#8. CAN I DRIVE AFTER TAKING THIS MEDICATION?

Although not very common, this medication can make you dizzy or can disturb your vision hence if that happens kindly avoid driving or operating any heavy machinery.

#9. IS Gempid 600mg Tablet 10 ‘S SAFE TO GIVE TO ELDERLY PATIENTS?

The dosage of the drug may be lower than normal due to decreased kidney and liver function since there is an increased risk of side effects. Discuss with your doctor.

#10. WILL I HAVE TO UNDERGO ANY TESTS WHILE USING Gempid 600mg Tablet 10 ‘S?

Yes, regular monitoring of serum levels of triglycerides, total cholesterol, LDL, HDL, liver transaminase, and creatinine levels should be checked before starting the treatment with Gempid 600mg Tablet 10 ‘S and periodically during the course. Also, people who are taking blood thinners should keep an eye on INR and PT as well.