Azafrine 50mg Tablet 10 ‘S

Categories: ,
Type

Tablet

Feature

50mg

Unit

'S

Formula

Azathioprine

Composition

Azathioprine 50 mg

Brand

Korea United Pharm Inc.

Prescription Required

Yes

How to use, Side effects, Uses, Formula & Composition

About 

Azafrine 50mg Tablet 10 ‘S performs the function of helping patients with new kidneys who have been through kidney transplants. It is commonly consumed along with other medications as well which prevent the organ from being rejected by the body and working normally. The medicine contains and is a kind of immunosuppressant. They weaken the immune system of the body so it is forced to accept the new kidney as if it was it is own. 

{{Product}} can also be prescribed for the treatment of rheumatoid arthritis, {{Product}} however may take up to 2 months to show results for the following disease. {{Product}} consists of components that can be absorbed through the skin and lungs therefore pregnant women are strictly warned to avoid the use of this medication as it may harm the unborn baby. 

{{Product}} is preferred to be taken after food to avoid excessive side effects. The medicine might cause common side effects such as nausea or vomiting. The risks of patients developing skin cancers, leukemia, or fatal brain infection increase with the consumption of this medicine, however, a medical expert will only prescribe this medicine when the potential benefits outweigh the risks. 

Indications 

{{Product}} can be used to treat:

  • Prevention of rejection of new kidney
  • Rheumatoid arthritis 

How To Use {{Product}}

Azafrine 50mg Tablet 10 ‘S is to be ingested orally with water to help the tablet flow down the throat easily. It can be consumed with or without food and should not be chewed or crushed. Azafrine 50mg Tablet 10 ‘S should be ingested only as directed by the medical expert.

How Does {{Product}} Work

{{Product}} is an antimetabolite that performs the task of being an immunosuppressant. These are a class of medications that weaken and bring down the performance of the immune system so the joints or the new organ transplant can’t be attacked by the immune system. 

Dosage

Adult Dosage

Severe acute Crohn’s disease, Maintenance of remission of Cohn’s disease, Maintenance of remission of acute ulcerative colitis:

 2-2.5 mg/kg daily, some patients may respond to lower doses

Rheumatoid arthritis, Severe systemic lupus erythematosus, and other connective tissue disorders, Polymyositis:

Initially up to 2.5 mg/kg daily in divided doses, adjusted according to response, rarely more than 3mg/kg daily; maintenance1-3 mg/kg daily, discontinue if no improvement within 3 months

Autoimmune Conditions:

1-3 mg/kg daily, adjusted according to response, Discontinue if no improvement within 3 months 

Suppression Of Transplant Rejection:

1-2.5 mg/kg daily, adjusted according to response 

Severe Refractory Eczema:

1-3 mg/kg daily (with normal or high TPMT activity), 0.5-1.5 mg/kg daily (with intermediate PMT activity)

Generalized Myasthenia Gravis:

 Initially 0.5-1 mg/kg daily, then increased to 2-2.5 mg/kg daily, the dose is increased over 3-4 weeks

Pregnancy Use And Lactation 

{{Product}} is not deemed safe for pregnant women as it may harm the unborn child. Pregnant women or women planning to get pregnant are warned to not consume medicine as it is deemed unsafe for the fetus. 

Nursing mothers are also required to not consume the medicine or even inhale dust particles as the medicine can get excreted into breast milk and can cause the infant harm or serious side effects. 

Precautions 

The doctor should be informed about the following conditions before using Azafrine 50mg Tablet 10 ‘S:

  • Not to be taken with dairy products 
  • Increased risk of skin cancer
  • Increased risk of leukemia
  • Increased risk of brain infection. 
  • Allergic to components
  • Vulnerable to infections due to a weak immune system
  • History of kidney diseases
  • pregnant

Contraindications 

The doctor should be informed about the following/history of any of these before using {{Product}}:

  • Pregnant 
  • Breastfeeding 
  • Hypersensitivity to components 
  • Elderly
  • Chemotherapy 
  • Liver disease

Interaction With Other Medicines 

  • Febuxostat 
  • Cancer drugs 
  • Cyclophosphamide
  • Rituximab
  • Tofacitinib
  • Allopurinol 
  • Aminosalicylates
  • ACE inhibitors 
  • Warfarin
  • Ribavirin 

Adverse Effects 

Common Side Effects

  • Nausea
  • Vomiting
  • Temporary hair loss
  • Rash
  • Fever 
  • Tiredness
  • Dizziness 
  • Low blood pressure
  • Muscle aches 
  • Low blood cells
  • Fatigue
  • Reduced resistance to infections
  • Sensitized toward sunlight

Rare Side Effects

  • Liver disease
  • Severe abdominal/stomach pain
  • Dark urine
  • Yellow eyes/skin
  • Seizure
  • Visual changes
  • Trouble breathing
  • Allergic reaction

How To Cope-Up With Some Adverse Effects

Fatigue- Patients experiencing this adverse effect are advised to take deep breaths, intake tea or coffee, get a good night’s rest, and not overburden themselves for a few days.

Feeling or being sick (nausea or vomiting) or diarrhea –Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water.

Feeling dizzy or weak –If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

Muscular Aches And Pains- A hot or cold compress can be placed at the area of discomfort to bring relief; an over-the-counter pain reliever such as paracetamol or ibuprofen can be ingested to bring ease as well. Avoid high-intensity exercise while suffering from muscular pain.

Photosensitivity – patients are asked to wear sun-protective clothes when going outside including gloves and a hat, to apply generous amounts of broad-spectrum sunblock along with wearing sunglasses. Patients are advised to do all necessary work after sunset to reduce or eliminate sun exposure while undergoing treatment with Azafrine 50mg Tablet 10 ‘S.

FAQ’s

Q1. HOW TO STORE Azafrine 50mg Tablet 10 ‘S?

Azafrine 50mg Tablet 10 ‘S is to be kept away from the reach of children, in a cool dry place away from direct sunlight and humidity as that tends to ruin certain drugs.

Q2. WHAT IF I TAKE TOO MUCH OF Azafrine 50mg Tablet 10 ‘S?

In case of too much consumption by accident, kindly contact your doctor or nearby hospital right away. The amount of medication that can result in severe side effects varies from person to person.

Q3. WHAT IF I MISS A DOSE OF Azafrine 50mg Tablet 10 ‘S?

If you miss a dose of the medication, make sure you take it as soon as possible on that same day. If you don’t remember you missed the dose until the next dosage time or the next day, do not double the dose and take your medication as per schedule.

Q4. HOW IS Azafrine 50mg Tablet 10 ‘S SUPPOSED TO BE TAKEN?

Azafrine 50mg Tablet 10 ‘S is to be ingested orally with water to help the tablet flow down the throat easily. It can be consumed with or without food and should not be chewed or crushed. Azafrine 50mg Tablet 10 ‘S should be ingested only as directed by the medical expert.

Q5. WILL Azafrine 50mg Tablet 10 ‘S AFFECT MY SEXUAL ACTIVITY?

No, there isn’t sufficient evidence to suggest that patients experience a decrease in libido.

Q6. Can I Take Azafrine 50mg Tablet 10 ‘S During My Pregnancy?

No Azafrine 50mg Tablet 10 ‘S is deemed unsafe to be ingested during pregnancy.

Q7. WILL Azafrine 50mg Tablet 10 ‘S AFFECT MY FERTILITY??

No, there isn’t sufficient evidence to suggest that patients experience a decrease in fertility.

Q8. CAN Azafrine 50mg Tablet 10 ‘S CAUSE DIZZINESS? IF SO, HOW SHOULD I MANAGE IT?

Yes. It can cause dizziness as one of the most common side effects. If this happens, you should sit or lie down until the symptoms pass. However, please note this is temporary and usually goes away as the treatment continues. It is also advised to avoid the consumption of alcohol during this treatment, as it may worsen the dizziness.

Q9. WHY MUST I PROTECT MY SKIN FROM THE SUN WHILE TAKING Azafrine 50mg Tablet 10 ‘S?

Treatment with Azafrine 50mg Tablet 10 ‘S may lead to the skin becoming sensitive to sun damage and it is therefore recommended for patients to wear sunscreen at all times, along with hats and gloves whenever possible to protect themselves from sun damage.