Provate-G Cream 15 gm


  • Provate-G Cream 15 gm 15mg is available in a travel-friendly tube.
  • Provate-G Cream 15 gm is only for topical application
  • Provate-G Cream 15 gm contains Betamethasone Dipropionate 0.05%, Gentamicin Sulphate 0.1% as active pharmaceutical ingredients.
  • Provate-G Cream 15 gm is used in the treatment of eczema, dermatitis, allergies, and rash.
  • Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor.

Cream – Tube


15 gm




Betamethasone Dipropionate


Betamethasone Dipropionate 0.05% + Gentamicin Sulphate 0.1 %


Saffron Pharmaceuticals (Pvt) Ltd.

Prescription Required


How to use, Side effects, Uses, Formula & Composition


Provate-G Cream 15 gm belongs to a class of topical medicines which is a combination of synthetic steroid (Glucocorticoid) and aminoglycoside antibiotic (Gentamicin Sulfate). Provate-G Cream 15 gm is prescribed for the treatment of several inflammatory skin conditions, suited for conditions with an ongoing bacterial infection as well caused by eczema, dermatitis, psoriasis, infected wounds, etc. it is mainly used when other topical medicines fail to treat infectious inflammatory skin conditions. Vulnerable bacterial species include mild to moderate infections due to staphylococcus aureus, streptococci, Pseudomonas, and some other sensitive strains.

Provate-G Cream 15 gm contains Betamethasone dipropionate and Gentamicin which acts by reducing inflammation exhibited by swelling and redness, as well as inhibiting protein synthesis in susceptible bacteria and disrupting the cell membrane. Therapeutic outcomes of Provate-G Cream 15 gm have been well-received due to its dual mode of action against inflammatory skin conditions. 

Provate-G Cream 15 gm is available in the form of cream and ointment in a tube, meant for external use only. Provate-G Cream 15 gm can be applied in a thin coat over the affected area on the skin with clean hands, two to three times daily. Usually, clinical improvements can be seen in a few days and the treatment may last up to 7-10 days or as advised by your doctor. Common side effects of Provate-G Cream 15 gm include skin rash, itching, and skin dryness. 


Provate-G Cream 15 gm is prescribed for the management of a variety of skin conditions including:

  • Dermatitis (atopic, contact)
  • Severe eczema 
  • Psoriasis 
  • Infected dermatoses 
  • Infectious wounds/burns
  • Seborrhoeic dermatitis
  • Folliculitis 
  • Impetigo
  • Ecthyma gangrenosum 

How Does Provate-G Cream 15 gm Work

Provate-G Cream 15 gm is more suited for inflammatory skin conditions with concurrent bacterial infection. It works by acting on the skin via two basic mechanisms. Firstly, Betamethasone being a Glucocorticoid controls the production of proteins that lead to inflammation by binding to Glucocorticoid receptors and interacting with DNA sequence. Also, it controls the infiltration and migration of inflammatory cells like leukocytes. It also inhibits Phospholipase A2 which speeds up the process of prostaglandin formation, a key mediator in inflammatory reactions. Provate-G Cream 15 gm thus decreases the inflammation. Secondly, Gentamicin via its bactericidal effects through cell membrane disruption and impaired protein synthesis inhibits the production of bacterial proteins thereby killing bacteria.

How to use Provate-G Cream 15 gm

Provate-G Cream 15 gm is available in the form of ointment and cream meant for external use only to be applied with clean hands usually two to three times daily after washing the affected skin properly and gently drying afterward. Provate-G Cream 15 gm is safe for use in adults and children above 2 years of age. In children, careful application and monitoring are advised to avoid accidental ingestion. Betamethasone dipropionate is a high-strength steroid, thus a prolonged application is not advised.


  • Wash and gently pat dry your skin before applying the Provate-G Cream 15 gm. 
  • Remove the cap by gently rotating it, break the top seal with the help of the pointed end given on the outer cap
  • Take out a small amount of {{product} on fingertips and gently rub it in to form a thin, even coat over the affected area.
  • Wash your hands after application, an additional amount can be reapplied if Provate-G Cream 15 gm gets wiped off from any part.
  • {{product} is applied to the skin commonly two to three times a day for 7-10 days or as per the doctor’s suggestion


Provate-G Cream 15 gm is not used for very long periods. Treatment is commonly prescribed for 7-10 days, if there’s no improvement in your symptoms after 7 days of application, consult your doctor who may consider changing the medicine for you.

Dosage for the cream form can be estimated as per fingertip units (fingertip of forefinger)

Adult Dosage

A thin film of Provate-G Cream 15 gm is to be applied twice or thrice a day, or as instructed by a physician.

A small amount on fingertips should be gently rubbed in. Application on the face is not advised for more than 5 days.

Child Dosage

Provate-G Cream 15 gm must not be used on children without consulting a doctor. It is not considered safe for application in patients aged 2 years and younger. Provate-G Cream 15 gm is not recommended to be used for more than 7 days.

Smaller amounts should be applied to a child’s body due to height and physique differences.

Commonly a pea-sized quantity on the fingertip is sufficient to cover the affected skin. Do not use Provate-G Cream 15 gm to treat diaper rash in infants.

Elderly Dosage 

For elderly patients the dosage of the drug may be lower than normal due to decreased kidney function, although Provate-G Cream 15 gm is absorbed through the skin in insignificant amounts but may pose a problem in elderly patients so, in such cases the doctor may prescribe an altered dose of the Provate-G Cream 15 gm.

Pregnancy use and lactation

Provate-G Cream 15 gm should not be applied during pregnancy, therefore if you are pregnant, or are planning to start a family, please do discuss Provate-G Cream 15 gm with your doctor before using it, who will only prescribe if deemed necessary. In case you are a lactating mother, the full effects of Provate-G Cream 15 gm in breastfed infants are not yet known therefore if you are breastfeeding an infant, please make sure to consult your doctor first before using it. 


Please inform your doctor if you have a history of any before using Provate-G Cream 15 gm:

  • Allergy to Provate-G Cream 15 gm or one of its constituents
  • Skin lesions due to viral infection (example herpes)
  • Skin lesions due to fungal infection (example athlete’s foot)
  • Cushing’s disease
  • Pregnancy 
  • Glaucoma (especially avoid application near eyes)
  • Any skin condition likely to aggravate with  Provate-G Cream 15 gm such as acne

Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Provate-G Cream 15 gm:‌ 

  • If there is a history of allergy to similar medicines 
  • Make sure to wash your hands thoroughly after application, avoid getting ‌Provate-G Cream 15 gm in your eyes
  • Do not use ‌Provate-G Cream 15 gm for long durations in continuity, if there is no noticeable difference in your condition after a week contact your doctor
  • ‌Provate-G Cream 15 gm contains high strength steroids which may put you at risk of infections or slow wound healing due to immunosuppression if used for prolonged periods, take precautions accordingly 
  • Avoid applying to open wounds or cracked skin except if advised by the doctor
  • Betamethasone in ‌Provate-G Cream 15 gm is a steroid that when used for a longer duration can cause suppression of adrenal function
  • Avoid applying to sensitive parts like inside the nose, mouth or around the mouth, genitals, near eyes 
  • Avoid using Provate-G Cream 15 gm for treatment of diaper rash in infants
  • Avoid going near fire or open flames to avoid risking burns
  • Provate-G Cream 15 gm may initially cause exacerbation of existing symptoms or cause itching, redness, or irritation of the skin which should subside
  • Provate-G Cream 15 gm is best applied on naked skin without any bandages except if advised to loosely cover it by your doctor
  • Use of Provate-G Cream 15 gm may cause an overgrowth of some other bacterial strains causing superinfection in which case consult a doctor immediately who may ask you to discontinue the use

Interaction with other medications

Topical medicines are rarely affected by interaction with other drugs. But some drugs may increase or decrease their absorption. Make sure to inform your doctor about all the drugs you’re currently taking, in which case, your doctor might alter the treatment. 

  • Other skin medications (you can apply such drugs at different timings)
  • Cosmetics (may decrease the efficacy, especially on the face)
  • Skin products that might irritate the skin
  • Tobramycin 
  • Amikacin

Adverse effects

Like most medicines, Provate-G Cream 15 gm has some side effects which include:

Common Side effects

  • Itching/ pruritis
  • Redness
  • Dryness of skin 
  • Flaky skin
  • Tingling/ burning sensation at the site of application

Rare side effects

  • Anaphylactic reaction
  • Headache 
  • Blurred vision
  • Pain in eyes 
  • Dizziness 
  • Blistering
  • Temporary exacerbation of symptoms
  • High intraocular pressure in eyes (if used in large amounts / near the eye)
  • Superinfection 

List Of How To Deal With Adverse Affects

  • Allergic Reactions – Allergic reactions to the drug may be mild to severe or potentially could be life-threatening. If allergy is suspected immediately take anti-allergy (anti-histamine) medicine which will stop the mild reaction. If a serious allergic reaction is suspected rush to the nearby hospital and avoid Provate-G Cream 15 gm and drugs with similar compounds in the future.
  • Skin Rash/ Blisters – can be eased by applying soothing and healing lotions or creams such as calamine or organic aloe vera lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. An antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.
  • Dryness – apply a moisturizer to the skin and wait for 10-15 minutes after which apply Provate-G Cream 15 gm onto the skin. This will prevent skin from getting dry and flaky.
  • Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
  • Feeling or being sick (nausea or vomiting) or diarrhea – Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water. 
  • Feeling dizzy (lightheaded) or weak – If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better and do not rise too fast or immediately from sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.
  • Blurred vision- This side effect tends to go away on its own in a few days; patients are advised to not operate heavy machinery or drive any motorized vehicles in the meantime.If blurred vision persists, please contact your doctor.
  • Photosensitivity – patients are asked to wear sun-protective clothes when going outside including gloves and hat, to apply generous amounts of broad-spectrum sunblock along with wearing sunglasses. Patients are advised to do all necessary work after sunset to reduce or eliminate sun exposure while undergoing treatment with Provate-G Cream 15 gm.


# 1. How To Store Provate-G Cream 15 gm?

Provate-G Cream 15 gm is to be kept away from the reach of children, in a cool dry place above 25°C,  away from direct sunlight and humidity as that tends to change the chemical nature of certain drugs.

# 2. What If I Use Too Much Of Provate-G Cream 15 gm?

In case of excessive usage or accidental ingestion, kindly contact your doctor or nearby hospital right away. The amount of medication that can result in severe side effects varies from person to person. Toxicity results in slowing down of heart rate and difficulty breathing accompanied by dizziness and abdominal pain.

# 3. How Is Provate-G Cream 15 gm Supposed To Be Taken?

Provate-G Cream 15 gm  is available in ointment and cream form to be applied topically only over the affected area

# 4. Can I Use Other Skincare Products Alongside Provate-G Cream 15 gm?

In case you want to use other skin creams or ointments, make sure you use those products at a different time. Avoid applying make-up as well while using Provate-G Cream 15 gm on the face

# 5. Can I Take Provate-G Cream 15 gm During My Pregnancy?

Provate-G Cream 15 gm should not be used in pregnancy due to potentially harmful effects on the unborn baby. Consult your doctor regarding the safety of Provate-G Cream 15 gm first

#6. Will Provate-G Cream 15 gm Affect My Fertility?

No, there isn’t sufficient evidence to suggest that patients experience a decrease in fertility.

# 7. Can I Take Provate-G Cream 15 gm While Breastfeeding?

Full effects of Provate-G Cream 15 gm in breastfed infants are not yet known therefore if you are breastfeeding an infant, please make sure to consult your doctor first before using it. 

# 8. Can Provate-G Cream 15 gm Cause Dizziness? If So, How Should I Manage It?

No, in general Provate-G Cream 15 gm does not cause dizziness but may occur as a rare side effect or may experience blurred vision. If this happens, you should sit or lie down until the symptoms pass. However, please note this is temporary and usually goes away as the treatment continues. It is also advised to avoid the consumption of alcohol during your treatment, as it may worsen the dizziness.

# 9. How long Will I Have To Continue Taking  Provate-G Cream 15 gm?

It may be used twice or thrice a day. Treatment can last up to 7-10 days depending on your condition and response to the Provate-G Cream 15 gm. Treatment must not continue for longer periods in continuity.

# 10. Is It Safe To Have Painkillers Alongside Provate-G Cream 15 gm?

Yes, painkillers are safe to be ingested along with Provate-G Cream 15 gm 

# 11. Can I go Outside After Applying Provate-G Cream 15 gm?

Commonly Provate-G Cream 15 gm is prescribed to be applied 2-3 times daily, you should avoid sun or UV exposure. Sensitivity to the sun may develop therefore If it is necessary to step outside make sure to protect your skin from direct sun or wear a sunblock or clothes covering your skin.

# 12. What if I accidentally get Provate-G Cream 15 gm in my eyes?

Careful application of Provate-G Cream 15 gm is necessary to avoid getting in your eyes because it can aggravate pre-existing glaucoma. If you accidentally get it in your eyes, thoroughly wash/rinse your eyes with cold tap water and immediately seek a doctor if necessary.