Admore 400 IU Drop 10 ml

Description

About 

{{Product}} contains Vitamin D3 as an active constituent that is used to treat medical conditions like osteoporosis, chronic kidney disease, and hypoparathyroidism. Vitamin D3 is needed in the right amounts in the body to balance the phosphorus and calcium needs which in turn regulates metabolic functions such as bone metabolism and transcription regulation. 

Vitamin D is naturally produced through diet as it is present in eggs, cheese, and fish, and through photochemical conversion of 7-dehydrocholesterol to Vitamin D3 in the skin. Inadequate exposure to sunlight, insufficient dietary intake, genetic defects with vitamin D receptors, and severe kidney or liver disease are the factors that cause the deficiency of Vitamin D resulting in osteomalacia, rickets, inadequate bone mineralization, increased secretion of parathyroid hormone, and low calcium levels in the blood. 

Indications

{{Product}} is indicated for the management of: 

• Deficiency of Vitamin D resulting from intestinal malabsorption or chronic liver disease.

• Hypocalcemia resulting from hypothyroidism in patients with osteodystrophy (abnormal changes in the growth and bone formation).

• Refractory rickets (lack of response to vitamin D)

• Hypoparathyroidism (low production of parathyroid hormone) 

• Familial Hypophosphatemia (inherited disorders with impaired phosphate conservation through kidneys and altered vitamin D metabolism)

• Supplementation to maintain sufficient Vitamin D levels in the body such as in osteoporosis and chronic kidney disease.

How Does Admore 400 IU Drop 10 ml Work

{{Product}} contains the active agent cholecalciferol, a vitamin D analog. The principal function of Vitamin D is to maintain serum levels of calcium and phosphorus by increasing the mineral absorption efficacy of the small intestine. 

There is a conversion of Vitamin D3 to its active form in the liver, which is further hydroxylated to its active metabolite in the kidney. The final metabolite then binds to the endogenous Vitamin D receptors resulting in regulatory roles such as maintenance of calcium levels, parathyroid hormone regulation, regulation of renal calcium absorption, enhanced bone to plasma calcium and phosphorus mobilization, and enhanced intestinal calcium & phosphorus absorption. 

How To Use Admore 400 IU Drop 10 ml

Take Admore 400 IU Drop 10 ml orally (by mouth), with or without meals. It is taken preferably after meals. Take it at bedtime if you are taking other medications. 

Dosage

Each drop contains 400IU Cholecalciferol (Vitamin D3) which is equivalent to 10mcg 

  Adult Dose

Two to three drops daily 

Pediatric Dose

Children and infants below 4 years: One drop daily

Children above 4 years: Two drops daily

Pregnancy And Lactation

Can be prescribed to pregnant women and lactating mothers if needed, but the dose shouldn’t exceed above 2000IU as daily intake.

Contraindications

• Known hypersensitivity to Vitamin D 

• Hypercalcemia (Increased blood calcium levels) 

• Kidney stones

• Hypercalciuria (Excessive calcium in the urine) 

• Severe Arteriosclerrosis 

• Pseudohypoparathyroidism (inadequate response to parathyroid hormone) 

• Severe renal impairment 

Precautions

• {{Product} should be used with caution in a pregnant and lactating woman. 

• In case of long-term treatment, plasma calcium and phosphate should be regularly monitored along with serum and urinary calcium checks.

• {{Product}} should be given with caution in patients with underlying cardiovascular disorders.

• {{Product}} should not be given to patients with hypercalcemia (high blood calcium levels) and hyperphosphatemia (high serum phosphate levels).

Interactions With Other Medications

• Anticonvulsants (Barbiturates, Carbamazapine) 

• Thiazides 

• Digitalis 

• Colestipol

• Sucralfate

• Phenytoin 

• Cholestyramine

• Glucocorticoid 

• Isoniazid 

• Rifampicin 

• Orlistat 

• Imidazole 

• Actinomycin 

• Digoxin 

Adverse Effects

Symptoms of overdose include: 

• Anorexia 

• Loss of appetite 

• Lack of energy 

• Nausea

• Vomiting 

• Diarrhea 

• Constipation 

• Excessive urination 

• Weightloss

• Sweating

• Headache 

• Thirst

• Vertigo 

How To Cope With Some Of The Adverse Effects

• Constipation- Drink plenty of water, and increase the intake of fiber diet, vegetables like mint, and ginger. Avoid smoking and alcohol intake. Do not lie down immediately after having a meal. 

• Headache – Using a cold pack or hot compress helps in relieving headaches, and caffeine helps reduce pain, you can also take an over-the-counter analgesic medication if pain persists.

• Nausea –  Take small and frequent meals, and avoid taking heavy meals. Stay in the fresh air, chew peppermint gum, or take peppermint tea. You can also take an anti-emetic if there are episodes of vomiting, after discussing it with your doctor. 

• Diarrhea – Drink lots of water to stay hydrated, and take light and healthy meals.  Avoid medications that may increase gastric motility. Intake Oral Rehydration Salt (ORS) gets the electrolyte levels back to normal.

FAQ’s 

• HOW DOES {{PRODUCT}} WORK?

{{Product}} contains the active agent cholecalciferol, a vitamin D analog that is converted into its active form in the liver, which is further converted into its active metabolite in the kidney. The final metabolite then binds to the endogenous Vitamin D receptors resulting in regulatory roles such as maintenance of calcium levels, parathyroid hormone regulation, regulation of renal calcium absorption, enhanced bone to plasma calcium and phosphorus mobilization, and enhanced intestinal calcium & phosphorus absorption.

• CAN I DRINK ALCOHOL DURING THE TREATMENT WITH {{PRODUCT}}?

There is no interaction between alcohol or alcoholic beverages and Vitamin D3. However, you should limit alcohol intake if you feel dizzy or lightheaded. 

• WHAT IS THE RECOMMENDED DAILY ALLOWANCE OF VITAMIN D3?

The recommended dietary allowance (RDA) of Vitamin D3 is: 

400IU (10mcg) for infants up to 12 months 

600IU (15mcg) for adults and children above 1 year

800IU (20mcg) for geriatrics above 70 years of age

• CAN A PREGNANT OR NURSING MOTHER TAKE {{PRODUCT}}?

{{Product}} should be given to a pregnant or lactating woman only if clinically needed. However, the dose shouldn’t exceed above 2000IU as a daily intake.

• WHAT ARE THE STORAGE CONDITIONS OF {{PRODUCT}}?

{{Product}} should be stored at room temperature, protected from excessive heat and light. 

• CAN I DRIVE A BIKE AFTER USING {{PRODUCT}}?

{{Product}} does not make you feel dizzy. However, driving should be avoided in case of weakness and lethargy. 

• WHAT IF I MISS THE DOSE?

Take it as soon as you remember. You can skip the previous dose if it is time for the next dose but do not repeat the dose. 

• CAN I STOP TAKING {{PRODUCT}} ABRUPTLY?

Although, the Admore 400 IU Drop 10 ml does not cause withdrawal symptoms the treatment should be completed to overcome the nutritional deficiency significantly.