Dipof 3mg/25mg Tablet 20 ‘S

Dipof 3mg/25mg Tablet 20 ‘S is prescribed for the treatment of bipolar disease,major depressive disorder,schizophrenia and similar illnesses

Dipof 3mg/25mg Tablet 20 ‘S contains olanzapine and fluoxetine 

Dipof 3mg/25mg Tablet 20 ‘S is commonly prescribed to patients aged 18 years and above 

Dipof 3mg/25mg Tablet 20 ‘S is to be taken orally (via mouth)

A box of 14 capsules of Dipof 3mg/25mg Tablet 20 ‘S come packaged and sold separately.

 

Categories: ,
Type

Tablet

Feature

3mg/25mg

Unit

'S

Formula

Olanzapine

Composition

Olanzapine 3 mg + Fluoxetine 25 mg

Brand

PharmEvo

Prescription Required

Yes

How to use, Side effects, Uses, Formula & Composition

About

Dipof 3mg/25mg Tablet 20 ‘S is an antipsychotic medication and belongs to a group of drugs known as Psychotherapeutic Combos. Dipof 3mg/25mg Tablet 20 ‘S is a combination of medications that are used to treat bipolar disorder-related depression (manic depression). This medication is prescribed when other drugs have failed for treatment. Dipof 3mg/25mg Tablet 20 ‘S contains Olanzapine and Fluoxetine as active ingredients. Olanzapine and fluoxetine function in the brain by enhancing the activity of neurotransmitters known as serotonin, norepinephrine, and dopamine. These substances aid in the alleviation of depression symptoms. Olanzapine is a type of antipsychotic medication and Fluoxetine is an antidepressant that belongs to the selective serotonin reuptake inhibitor class of drugs (SSRIs). 

Dipof 3mg/25mg Tablet 20 ‘S is available as a tablet form that is taken orally (by mouth) usually once daily in the evening, with or without food by adults and children (10-17yrs), or as directed by your doctor. Dipof 3mg/25mg Tablet 20 ‘S is not prescribed for children under 10 years of age and with older adults with dementia-related psychosis (as it can increase the risk of death in such patients). Avoid using Dipof 3mg/25mg Tablet 20 ‘S as a dangerous drug interaction can occur if you have used an MAO inhibitor in the last 14 days. Antidepressants can induce suicidal thoughts and behavioral changes in children, adolescents, and young adults. Monitor for worsening and the onset of suicidal thoughts and actions in patients of all ages who are starting antidepressant medication. Advise family members and caregivers on the importance of constant monitoring and communication with the healthcare provider. 

Diarrhea, drowsiness, dizziness, lightheadedness, weight gain, trouble sleeping, increased appetite are some of the side effects of Dipof 3mg/25mg Tablet 20 ‘S which may worsen if present for a longer period. Contact your doctor immediately. For each patient, the dosage of this medication will be different. Follow your doctor’s instructions or the label’s directions. Only the average doses of this drug are included in the following data. If your dose differs, do not alter it unless your doctor directs you to. The amount of medicine you take is determined by the medicine’s strength. In addition, the number of dosages you take each day, the duration between doses, and the length of time you take the medicine are all determined by the medical problem for which the medicine is being used. 

Indications

Dipof 3mg/25mg Tablet 20 ‘S is used for:

  • Bipolar I disorder
  • When other drugs have failed to alleviate depression (resistant depression) 

This medication can be used for several other conditions not included in this prescription guide. 

How Does Dipof 3mg/25mg Tablet 20 ‘S Work

Dipof 3mg/25mg Tablet 20 ‘S contains Olanzapine and Fluoxetine as active ingredients. Olanzapine and fluoxetine function in the brain by enhancing the activity of neurotransmitters known as serotonin, norepinephrine, and dopamine. These substances aid in the alleviation of depression symptoms. Olanzapine is a type of antipsychotic medication and Fluoxetine is an antidepressant that belongs to the selective serotonin reuptake inhibitor class of drugs (SSRIs). 

How to use Dipof 3mg/25mg Tablet 20 ‘S

Dipof 3mg/25mg Tablet 20 ‘S is available in tablet form. This medication in tablet form is taken by mouth usually once daily in the evening by an adult and children (10-17yrs), with or without food or as directed by your doctor.

  • It is recommended to take Dipof 3mg/25mg Tablet 20 ‘S in the evening because sleepiness is one of the common side effects of this medicine.
  • Dipof 3mg/25mg Tablet 20 ‘S can make your body unable to control its temperature, try to remain hydrated to prevent overheating
  • Dipof 3mg/25mg Tablet 20 ‘S can decrease your blood pressure while changing positions such as from sitting to standing, to avoid falling and injuring yourself, be cautious when changing positions. 
  • If you’re using pimozide or thioridazine, or other kinds of fluoxetine or olanzapine, you shouldn’t use this medicine
  • Your symptoms may take up to four weeks to improve. If your symptoms do not improve after taking Dipof 3mg/25mg Tablet 20 ‘S as advised, contact your doctor.  
  • You should not abruptly discontinue using Dipof 3mg/25mg Tablet 20 ‘S. To taper your dose, follow your doctor’s recommendations. 

Dosage

Form and strength:

Capsule: 3mg-25mg

Capsule: 6 mg-25mg

For Treatment of Bipolar I disorder:

Adult dosage:

Initial dose: Fluoxetine 25 mg and olanzapine 6 mg orally, once a day in the evening

Maintenance dose: Fluoxetine: 25 to 50 mg orally once a day

                               Olanzapine: 3 to 12 mg orally once a day

Maximum dose: Fluoxetine 50 mg and olanzapine 12 mg orally, once a day in the evening

Child Dosage:

Children 10-17 years of age:

Initial dose: Fluoxetine 25 mg and olanzapine 3 mg orally, once a day in the evening

Maintenance dose: Fluoxetine: 25 to 50 mg orally once a day

                               Olanzapine: 6 to 12 mg orally once a day

Maximum dose: Fluoxetine 50 mg and olanzapine 12 mg orally, once a day in the evening

Elderly dosage:

Initial dose: Fluoxetine 25 mg and olanzapine 3 mg to Fluoxetine 25 mg and olanzapine 6 mg orally once a day in the evening

Maintenance dose: Fluoxetine: 25 to 50 mg orally once a day

                               Olanzapine: 6 to 12 mg orally once a day

Maximum dose: Fluoxetine 50 mg and olanzapine 12 mg orally, once a day in the evening

For treatment of Resistant Depression:

Adult dosage:

Initial dose: Fluoxetine 25 mg and olanzapine 6 mg orally, once a day in the evening

Maintenance dose: Fluoxetine: 25 to 50 mg orally once a day

                               Olanzapine: 3 to 12 mg orally once a day

Maximum dose: Fluoxetine 50 mg and olanzapine 12 mg orally, once a day in the evening

Child Dosage:

Children 10-17 years of age:

Initial dose: Fluoxetine 25 mg and olanzapine 3 mg orally, once a day in the evening

Maintenance dose: Fluoxetine: 25 to 50 mg orally once a day

                               Olanzapine: 6 to 12 mg orally once a day

Maximum dose: Fluoxetine 50 mg and olanzapine 12 mg orally, once a day in the evening

Elderly dosage:

Initial dose: Fluoxetine 25 mg and olanzapine 3 mg to Fluoxetine 25 mg and olanzapine 6 mg orally once a day in the evening

Maintenance dose: Fluoxetine: 25 to 50 mg orally once a day

                               Olanzapine: 6 to 12 mg orally once a day

Maximum dose: Fluoxetine 50 mg and olanzapine 12 mg orally, once a day in the evening

Pregnancy and Lactation

If you’re pregnant, talk to your doctor about using Dipof 3mg/25mg Tablet 20 ‘S. Taking an SSRI antidepressant late in pregnancy might lead to major medical problems for the baby. If you stop taking your antidepressant, you may have a recurrence of depression. If you become pregnant, call your doctor right away. Do not start or stop taking this medication without consulting your doctor. 

Breastfeeding may not be safe while taking Dipof 3mg/25mg Tablet 20 ‘S. However if Dipof 3mg/25mg Tablet 20 ‘S was used throughout pregnancy or if other antidepressants were ineffective, it has been recommended that it can be continued while breastfeeding. Alternatively, when nursing a newborn or premature infant, drugs with a lower excretion into breast milk may be chosen. Inquire with your doctor about any potential risks. 

Contraindications

Do not take Dipof 3mg/25mg Tablet 20 ‘S and consult your doctor if you have a medical history of any of the following:

  • Allergic/hypersensitive to Dipof 3mg/25mg Tablet 20 ‘S and its contents, or any food product (such as pork, beef, etc)
  • If you’re using pimozide or thioridazine, or other kinds of fluoxetine or olanzapine, you shouldn’t use this medicine
  • Avoid using Dipof 3mg/25mg Tablet 20 ‘S as a dangerous drug interaction can occur if you have used an MAO inhibitor in the last 14 days. 
  • Coadministration can result in Serotonin syndrome: symptoms include myoclonus, diaphoresis, nausea, vomiting, dizziness, tremor, hyperthermia with characteristics resembling neuroleptic malignant syndrome, change in mental status leading to delirium and coma
  • After discontinuing treatment with Dipof 3mg/25mg Tablet 20 ‘S, do not take an MAO inhibitor for at least 5 weeks. 
  • Dipof 3mg/25mg Tablet 20 ‘S is not prescribed for children under 10 years of age
  • Dipof 3mg/25mg Tablet 20 ‘S is not prescribed for older adults with dementia-related psychosis (as it can increase the risk of death in such patients).

Precautions

Take special care and please tell your doctor about any of the following conditions before using Dipof 3mg/25mg Tablet 20 ‘S:

  • Liver disease
  • Heart problems
  • Narrow-angle glaucoma
  • Breast cancer
  • Bleeding problems
  • A seizure
  • A stroke
  • Low White Blood Cell counts
  • History of Diabetes, high cholesterol or triglycerides can increase your blood sugar levels and cholesterol leading to large appetite and weight gain
  • An enlarged prostate
  • Trouble swallowing
  • Use caution in patients with urinary retention
  • Antidepressants can induce suicidal thoughts and behavioral changes in children, adolescents, and young adults
  • Monitor for worsening and the onset of suicidal thoughts and actions in patients of all ages who are starting antidepressant medication. Advise family members and caregivers on the importance of constant monitoring and communication with the healthcare provider. 
  • In patients treated with fluoxetine, postmarketing incidences of QT interval prolongation and cardiac arrhythmia, including torsade de pointes, have been documented
  • Pregnancy and breastfeeding
  • Dipof 3mg/25mg Tablet 20 ‘S can induce a life-threatening condition called Neuroleptic Malignant Syndrome (NMS):
  • Symptoms include high fever, confusion, muscle stiffness, sweating, changes in heart rate and blood pressure
  • A serious skin reaction called Drug Reaction with Eosinophilia can occur due to Dipof 3mg/25mg Tablet 20 ‘S:
  • Symptoms include fever, rash, and swollen lymph nodes

Interactions With Other Medications

Consult your doctor about the use of the following medicines before using Dipof 3mg/25mg Tablet 20 ‘S:

  • Lorazepam
  • amphetamine/dextroamphetamine
  • Cyclobenzaprine
  • Clonazepam
  • Fluoxetine
  • Topiramate
  • HIV drugs
  • Antimalarial drugs
  • Cancer drugs
  • Drugs used for heart problem
  • Drugs used for mental illness
  • Drugs used for infections
  • Drugs used for asthma
  • NSAIDs such as aspirin and Ibuprofen
  • Drugs that make you drowsy and slow down your breathing such as opioids, a muscle relaxer, cold or allergy medicine, sleeping pill, etc

This document does not contain all probable drug reactions, it is advisable to keep a list of medicines in use and discuss it with your doctor ( this includes prescription/nonprescription and herbal products). 

Adverse Effects

Common Adverse Effects

Following side effects may not require immediate medical attention until becomes troublesome:

  • Weight gain, increased appetite
  • Swelling in your hands or feet
  • Drowsiness
  • Blurred vision 
  • Dry mouth
  • Trouble concentrating 
  • Feeling tired
  • Tremor
  • Abnormal liver function or cholesterol tests

Rare Adverse Effects

Because Dipof 3mg/25mg Tablet 20 ‘S may induce serious and fatal infusion responses followed by cardiac collapse, the following side effects may require rapid attention and report to your doctor:

  • Any sign of an allergic reaction such as swelling of face, tongue, lips and throat, Hives, difficulty in breathing
  • Sign of a serious drug reaction with symptoms including Fever, Skin rash, Swollen glands, Unusual bruising, jaundice
  • High doses of Dipof 3mg/25mg Tablet 20 ‘S can cause a serious irreversible movement disorder especially in women and older adults (includes uncontrollable muscle movements of lips, tongue, face, eyes, arms, or legs
  • Unusual bleeding or bruising
  • Vision changes
  • Fast or pounding heartbeats, shortness of breath, fluttering in your chest, dizziness (like you might pass out) 
  • Symptoms of dehydration include extreme thirst or heat, inability to urinate, intense perspiration, or hot, dry skin. 
  • significant nervous system reaction: stiff/rigid muscles, high fever, sweating, disorientation, fast or irregular heartbeats, tremors, feeling faint
  • Signs of elevated blood sugar: Increased thirst, increased urination, hunger, fruity breath odor, confusion, upset stomach
  • Signs of low sodium level: headache, slurred speech, severe weakness, vomiting, loss of coordination, unsteadiness
  • Symptoms of low white blood cell count: Fever, chills, mouth sores, skin sores, sore throat, cough, and difficulty breathing 
  • Seek medical help immediately, If you have signs of serotonin syndrome including agitation, hallucinations, fever, sweating, shivering, high heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea,

This is by no means a complete list of possible negative effects. Contact your doctor or pharmacist if you experience any other side effects not listed above. 

How To Cope With Some Of The Adverse Effects

  • Dry Mouth- Can be helped by sipping water throughout the day, chewing sugarless gum and using alcohol-free mouthwash, allowing ice to melt in the mouth, or using a saliva substitute
  • Fever- patients are asked to ingest over the counter painkillers (such as Paracetamol), partake in plenty of fluids, and rest for a couple of days till the symptoms pass
  • Blurred vision- This side effect tends to go away on its own in a few days; patients are advised to not operate heavy machinery or drive any motorized vehicles in the meantime.If blurred vision persists, please contact your doctor.
  • Skin Rash- can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. Antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.
  • Dehydration- Patients are recommended to always care around a water bottle with them wherever they go and periodically keep sipping to prevent thirst and extremely dry mouth. Ice pops in hot weather and energy drinks (verified by the doctor) help combat dehydration.

FAQs

#1. How to store Dipof 3mg/25mg Tablet 20 ‘S?

Keep Dipof 3mg/25mg Tablet 20 ‘S in a container at room temperature. Protect from heat. Store in a cool, dry location. keep all medications in a secure location and should be kept out of the reach of children and pets.

#2. What is Dipof 3mg/25mg Tablet 20 ‘S composed of?

Dipof 3mg/25mg Tablet 20 ‘S contains Olanzapine and Fluoxetine as active ingredients.

#3. What if I take too much of Dipof 3mg/25mg Tablet 20 ‘S?

Seek medical attention right away if someone has overdosed and is experiencing dangerous symptoms like fainting out or having difficulties breathing. 

#4. What if I miss a dose of Dipof 3mg/25mg Tablet 20 ‘S?

If you miss a dose of the medication, make sure you take it as soon as possible on that same day. If you don’t remember you missed the dose until the next dosage time or the next day, do not double the dose and take your medication as per schedule.

#5. Can I take Dipof 3mg/25mg Tablet 20 ‘S during breastfeeding?

Breastfeeding may not be safe while taking Dipof 3mg/25mg Tablet 20 ‘S. However if Dipof 3mg/25mg Tablet 20 ‘S was used throughout pregnancy or if other antidepressants were ineffective, it has been recommended that it can be continued while breastfeeding. 

#6. Does Dipof 3mg/25mg Tablet 20 ‘S cause weight gain?

Weight gain is one of the common side effects of Dipof 3mg/25mg Tablet 20 ‘S. If you’re worried about gaining weight, talk to your doctor first. 

#7. When is it safe to stop taking Dipof 3mg/25mg Tablet 20 ‘S?

If you want to discontinue taking this medicine, talk to your doctor. It’s dangerous to stop taking the drug too soon. If necessary, your physician can work with you to devise a strategy for safely lowering your dose and eventually stopping the drug. 

#8. Can I take Dipof 3mg/25mg Tablet 20 ‘S with a medical history of diabetes?

Yes, Dipof 3mg/25mg Tablet 20 ‘S can be taken if you have diabetes. However, because this medication can raise blood sugar levels, you should keep a closer eye on them. Your diabetic medications might be adjusted if your blood sugar levels are too high. 

#9. Can I drink alcohol with Dipof 3mg/25mg Tablet 20 ‘S?

While using this medication, it’s advised to stay away from alcohol. Sleepiness and low blood pressure can be exacerbated by combining the two, increasing the risk of dangerous falls. 

#10. What lab tests will be prescribed while treatment with Dipof 3mg/25mg Tablet 20 ‘S and how often?

To monitor your progress and check for side effects, psychiatric/medical checkups and laboratory/medical testing (such as liver function tests, blood sugar, weight, blood pressure, and blood cholesterol/triglyceride levels) should be done regularly. 

#11. When using Dipof 3mg/25mg Tablet 20 ‘S, is it safe to drive or operate heavy machinery? 

It may not be safe to drive a car or operate heavy machinery if you feel sleepiness, dizziness, hypotension, or a headache as a side effect of this medication. If the medication makes you drowsy, dizzy or decreases your blood pressure significantly, you should not drive a vehicle. 

#12. Is it okay if I give Dipof 3mg/25mg Tablet 20 ‘S to someone who has the same signs and symptoms as me? 

This medication is intended for you. Never give it to anyone else, even if they appear to be in the same situation as you.

#13. What dietary instructions are to be followed when using Dipof 3mg/25mg Tablet 20 ‘S?

Continue to eat normally until your doctor tells you to switch to a specific diet.