Diabryl 2mg Tablet 1 ‘S

Description

About 

Diabryl 2mg Tablet 1 ‘S belongs to a class of drugs called “hypoglycemics” (anti-diabetics, sulfonylureas) that are used to treat and prevent the risk of developing type 2 diabetes.

Type 2 diabetes, also known as non insulin-dependent diabetes, is a condition resulting from a combination of insulin resistance, i.e, body cells failing to respond properly to the insulin produced, inadequate insulin secretion, and excessive production of glucagon. Progression of the disease may lead to insulin deficiency. This causes hyperglycemia. (high blood sugar levels)

This medicine is available in tablet form on prescription. It is prescribed to lower blood sugar levels by increasing insulin (hormone controlling blood sugar levels) production by the pancreas.

Dosage of Diabryl 2mg Tablet 1 ‘S depends on age, severity of condition, patient’s response to medicine and their comorbidities.

Common side effects of this medication are nausea, indigestion, diarrhoea, headache and dizziness.

Indications

Diabryl 2mg Tablet 1 ‘S is prescribed to adults above 18 years of age. It is not advised to give to children.

It is used in the treatment of 

• Type 2 diabetes (high blood sugar levels) – as an adjunctive therapy to diet and exercise

 

How does Diabryl 2mg Tablet 1 ‘S work?

It is an anti-diabetic medication that works by increasing insulin (a natural substance required in breaking down sugar) production by the pancreas and the ability of the body to utilise it effectively.

 

How to use Diabryl 2mg Tablet 1 ‘S?

It is better to take the medication with a meal to avoid side effects. Swallow the tablet whole with a glass of water. 

 

Dosage 

Diabryl 2mg Tablet 1 ‘S comes as 1mg, 2mg, 3mg and 4mg tablets. Starting dose is usually 1mg, taken once a day, recommended to be taken with your first meal of the day and make sure to have it around the same time everyday.

It is then gradually increased over a period of weeks or months (to avoid hypoglycemia – low blood sugar levels) upto an optimal dose of 4mg/day. Maximum daily dosage that can be given is 6mg.

Dosage is completely dependent on the age, severity of condition, patient’s response to medicine and their comorbidities. Your doctor may vary your dosage to regulate your blood sugar levels.

 

Pregnancy use and lactation

Use of Diabryl 2mg Tablet 1 ‘S is not recommended in pregnancy or while breastfeeding. Please inform your doctor if you are pregnant, planning to conceive or breastfeeding so that they can prescribe you a medicine accordingly without causing any complications for you or your baby.

 

Contraindications

Please inform your doctor if you have a history of any before using Diabryl 2mg Tablet 1 ‘S:

• Type 1 diabetes mellitus (condition in which your body does not produce insulin) 
• Pregnant, trying to get pregnant or breastfeeding
• Allergic reaction (hypersensitivity) to the product or other sulfonylureas or sulfonamides.
• Hepatic (liver) porphyria
• Kidney disease (for example if you are on dialysis)
• G6PD (glucose 6 phosphate dehydrogenase) deficiency – an inherited condition affecting red blood cells leading to hemolytic anemia.
• About to have surgery 
• Alcoholism
• Diabetic ketoacidosis (abnormally fast breakdown of fat)
• Diabetic coma (life-threatening condition causing unconsciousness)

 

Precautions

Please tell your doctor about any of the following conditions while using Diabryl 2mg Tablet 1 ‘S:

• Pregnancy and lactation
• Hypoglycemia (low blood sugar levels) – can be prevented by monitoring sugar levels in blood and urine, regularly. Signs indicating hypoglycemia are: blurred vision, confusion, anxiety, cool, pale skin, drowsiness, excessive hunger, fast heart beat, headache, nausea, anxiety and overall tiredness and weakness. Usually experienced by patients with autonomic neuropathy (damage of nerves controlling involuntary body functions) taking beta blockers, clonidine, reserpine, guanethidine or other sympatholytic drugs
• Liver disease (like hepatitis)
• Kidney impairment 
• Stress in situations like trauma, surgery – doctor might switch over to insulin in this case
• Weight gain
• Adrenocortical insufficiency (condition characterised by inability of adrenal glands to produce adequate steroid hormones)
• Elderly
• Alcohol intake
• Heart problem (indicated by signs like, chest pain, breathing difficulty, pain in arms, neck and back, sweating and vomiting)
• Allergic reactions (indicated by skin rash, swelling around face area, wheezing, chest tightness and breathing difficulty)

 

Interaction with other medications

Certain medications could interact with Diabryl 2mg Tablet 1 ‘S, hence, in that case your doctor might alter your dosage and make sure to monitor blood sugar levels more closely.

Please inform your doctor about the use of the following before taking Diabryl 2mg Tablet 1 ‘S:

• Insulin or other anti – diabetics
• Steroid tablets – e.g prednisolone
• Anti – tuberculosis drug – e.g rifampicin
• Angiotensin-converting enzyme (ACE) inhibitors used to treat high blood pressure and other heart problems
• Allopurinol
• Probenecid
• Quinolones
• Salicylates
• Sulfonamides
• Tetracyclines
• Trofosfamide
• Acetazolamide
• Barbiturates
• Corticosteroids
• Diazoxide
• Diuretics
• Epinephrine and other sympathomimetic agents
• Glucagon
• Laxatives
• Nicotinic acid (in high doses)
• Oestrogens
• Phenothiazines
• Phenytoin
• Thyroid hormones
• H2-receptor antagonists
• Clonidine
• Reserpine
• NSAIDs – e.g phenylbutazone
• Anticoagulants 
• MAOIs
• Beta blockers
• Anti bacterials – e.g chloramphenicol, clarithromycin
• Disopyramide
• Fibrates
• Azole antifungals
• Cyclophosphamide
• Pentoxifylline 
• Colesevelam
• Alcohol intake
• Male sex hormones

 

Adverse effects

Like most medicines, Diabryl 2mg Tablet 1 ‘S has some side effects which include:

Common:

• Nausea
• Indigestion
• Diarrhoea
• Headache
• Dizziness

Serious:

• Hypoglycemia (low blood sugar) indicated by feeling hungry, trembling or shaking, sweating, confusion and difficulty concentrating
• Anaphylaxis (allergic) reactions – difficulty breathing, swelling of your throat or tongue, hives, or difficulty swallowing
• Liver damage (hepatitis)
• Blood dyscrasias (blood disorder)
• Haemolytic anemia (low red blood cells because of rapid destruction)
• Thrombocytopenia (abnormally low levels of platelets)
• Transient visual disturbances
• Skin rash or itching – skin disease

 

How to cope with some of the adverse effects

• Nausea (feeling sick) – Take Diabryl 2mg Tablet 1 ‘S with meals and avoid having spicy food

• Vomiting and Diarrhoea – Keep yourself hydrated by having lots of fluids and if the problem persists, consult your doctor before taking any medication for vomiting and diarrhoea

• Headache – Take a painkiller, rest and keep yourself hydrated at all times.

• Dizziness – Try and rest until you feel better and refrain from driving or using any tools or machinery

• Hypoglycemia – Carry fast acting carbohydrates (like sweets and juice) to prevent your body from going into a state of hypoglycemia (low blood sugar)

Inform your doctor immediately if you experience any of the serious side effects.

 

Key facts about Diabryl 2mg Tablet 1 ‘S

• Diabryl 2mg Tablet 1 ‘S is used for the treatment of type 2 diabetes mellitus (condition resulting in elevated levels of sugar in the blood) 
• It is prescribed to adults above 18 years of age.
• It should be avoided in elderly, debilitated and malnourished patients.
• It works by increasing insulin (a natural substance required in breaking down sugar) production by the pancreas and the ability of the body to utilise it effectively.
• Diabryl 2mg Tablet 1 ‘S is best known to be taken with meals to avoid common side effects  like nausea, indigestion, diarrhoea, headache and dizziness
• Some people have shown to gain weight when taking Diabryl 2mg Tablet 1 ‘S.
• Matter of concern arises when you experience signs like chest pain, breathing difficulties, skin rashes or an allergic reaction and a fall in red blood cell and platelet count. In that case contact your doctor immediately.
• It is important for your doctor to monitor your blood sugar levels regularly, along with repeated tests to prevent you from any complications. 
• Patients need to avoid alcohol intake and other anti diabetic medications like insulin, along with maintaining a good diet to prevent hypoglycemic events. 
• Use of Diabryl 2mg Tablet 1 ‘S is not recommended in pregnancy or while breastfeeding.

FAQs

1. WHAT EXACTLY DOES Diabryl 2mg Tablet 1 ‘S DO?

People with type 2 diabetes fail to respond properly to the insulin produced,secrete inadequate insulin, or produce excessive glucagon. Diabryl 2mg Tablet 1 ‘S works by increasing insulin (a natural substance required in breaking down sugar) production by the pancreas and the ability of the body to utilise it effectively.

2. HOW LONG DOES IT TAKE FOR Diabryl 2mg Tablet 1 ‘S TO START WORKING?

It takes around 2-3 hours for Diabryl 2mg Tablet 1 ‘S to start working. Initially, you might not feel that it is effective, but that does not mean you stop taking the medicine thinking it is not working. Make sure to continue taking Diabryl 2mg Tablet 1 ‘S as directed by your doctor.

3. DOES Diabryl 2mg Tablet 1 ‘S MAKE YOU FEEL SLEEPY?

Sleepiness is not caused by the medicine itself, but because the Diabryl 2mg Tablet 1 ‘S can cause hypoglycemia (low blood sugar) when used with other anti-diabetics, you may feel sleepy and tired.

4. DOES Diabryl 2mg Tablet 1 ‘S CAUSE MEMORY LOSS?

It is not known to cause memory loss, but since it is responsible for hypoglycemia (low blood sugar) – a known side effect, it can make concentration difficult and results in decreased alertness.

5. DOES Diabryl 2mg Tablet 1 ‘S AFFECT KIDNEYS?

Since Diabryl 2mg Tablet 1 ‘S is mainly eliminated by the kidneys, people with severe kidney disease should avoid using this medicine. It does not affect those with normal kidney function and hence, is safe to use for them.

6. HOW LONG WILL I HAVE TO TAKE Diabryl 2mg Tablet 1 ‘S FOR?

Diabryl 2mg Tablet 1 ‘S is usually prescribed for long term use, possibly life long. Your dosage and time period is decided by your doctor after knowing the severity of your condition.

7. CAN I STOP TAKING Diabryl 2mg Tablet 1 ‘S?

This medicine largely controls your blood sugar levels, but does not cure your condition. Hence, do not just stop taking the medicine without consulting your doctor, otherwise your condition could possibly get worse.

8. IS IT NECESSARY TO TAKE Diabryl 2mg Tablet 1 ‘S WITH FOOD?

It is advised to take Diabryl 2mg Tablet 1 ‘S with or after meals to reduce side effects like, nausea, indigestion, diarrhoea, headache and dizziness.

9. CAN I DRINK ALCOHOL WHILE TAKING Diabryl 2mg Tablet 1 ‘S?

Avoid drinking alcohol while you are on Diabryl 2mg Tablet 1 ‘S as it can interfere with your treatment causing low blood sugar levels especially in aged patients and on occasions where you have skipped a meal.

10. WHAT IF I TAKE TOO MUCH OF Diabryl 2mg Tablet 1 ‘S?

An overdose of Diabryl 2mg Tablet 1 ‘S can cause hypoglycemia (low blood sugar) indicated by feeling hungry, trembling or shaking, sweating, feeling confused and having problems concentrating. It can also severely affect your kidneys, heart and can possibly cause an allergic reaction. Contact your doctor immediately if you experience any of these signs.

11. WHAT IF I FORGET TO TAKE Diabryl 2mg Tablet 1 ‘S?

Incase you miss a dose, take your next dose on time and do not try making up for the missed dose by doubling it up. If it helps to remind you, set an alarm so you do not miss any dose.

12. CAN I TAKE Diabryl 2mg Tablet 1 ‘S DURING PREGNANCY OR BREASTFEEDING?

Use of Diabryl 2mg Tablet 1 ‘S is not recommended in pregnancy or while breastfeeding. Please inform your doctor if you are pregnant, planning to conceive or breastfeeding so that they can prescribe you a medicine accordingly without causing any complications for you or your baby.

13. WHAT IF Diabryl 2mg Tablet 1 ‘S IS NO LONGER WORKING?

Type 2 diabetes is a progressive disease which means, in the long run, your body might start producing even less insulin than before and its ability to utilise the insulin produced could deteriorate as well. Hence, the dose of Diabryl 2mg Tablet 1 ‘S is usually increased over time to manage your blood glucose levels. At times, Diabryl 2mg Tablet 1 ‘S alone might not be effective and in that case your doctor will prescribe a combination of medicines so that your body is more reactive to it.

14. CAN I DRIVE OR RIDE A BIKE AFTER TAKING Diabryl 2mg Tablet 1 ‘S?

Diabryl 2mg Tablet 1 ‘S alone might not affect your ability to drive or ride a bike, but when given in combination with other medicines, it could result in low blood sugar levels resulting in loss of concentration vision impairment (your eyesight is affected). To be on the safe side, always carry fast acting carbohydrates (like sweets and juice) to prevent your body from going into a state of hypoglycemia (low blood sugar)

15. HOW SHOULD Diabryl 2mg Tablet 1 ‘S BE STORED?

Keep the medicine at room temperature in a cool, dry place, away from direct sunlight. Make sure to keep it away from pets, children and other people.