Gen-M 30mg Ampule 2 ml
Description
About
Gen-M 30mg Ampule 2 ml belongs to a group of medicines called antimalarials. Gen-M 30mg Ampule 2 ml is used for the initial treatment of severe malaria. Gen-M 30mg Ampule 2 ml comes in injection form. It can be used in adults and children.
Gen-M 30mg Ampule 2 ml is an artemisinin derivative. Gen-M 30mg Ampule 2 ml hinders the normal function of Plasmodium parasites. Gen-M 30mg Ampule 2 ml has a short duration of action due to its short life. Gen-M 30mg Ampule 2 ml may cause side effects such as renal failure, hemoglobinuria, and jaundice.
Indications
Gen-M 30mg Ampule 2 ml can be used for:
- Initial treatment of severe malaria
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Cerebral malaria
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Second-line treatment in chloroquine-resistant falciparum malaria
How Does Gen-M 30mg Ampule 2 ml Work
Gen-M 30mg Ampule 2 ml is an antimalarial drug. Gen-M 30mg Ampule 2 ml is an artemisinin derivative that is rapidly metabolized to active dihydroartemisinin. Dihydroartemisinin generates free radicals to inhibit the normal function of plasmodium parasites.
How To Use Gen-M 30mg Ampule 2 ml
Gen-M 30mg Ampule 2 ml comes in injection form. Gen-M 30mg Ampule 2 ml can be given via intramuscular or intravenous route. For the IM route dissolve the product with 1 mL of 5% sodium bicarbonate and inject. For slow IV infusion, dissolve Gen-M 30mg Ampule 2 ml with 1 mL of 5% sodium bicarbonate and add 5 mL of 0.9% sodium chloride and inject. Injection should be injected immediately, if the solution appears cloudy or sedimentation occurs the injection should be rejected.
Dosage
The recommended dosage:
Adults
Severe malaria
2.4mg/Kg at 0, 12, and 24 hours then 2.4mg/Kg daily for up to 7 days.
Reconstitution Method Gen-M 30mg for Injection
Step 1: Add 0.5ml Sodium Bicarbonate Inj. 5% in vial & mix well until clear solution. Step 2: For I.V use: Add 2.5ml Sodium Chloride Inj. 0.9% in the vial (Step 1) & mix well & use by slow I.V route over 2-3 minutes (Do not put the solution in an I.V drip).
For I.M use
Add 1 ml Sodium Chloride Inj. 0.9% in vial (Step 1) & mix again & use by I.M route.
Gen-M 60mg for Injection
Step 1: Add 1ml Sodium Bicarbonate Inj. 5% in vial & mix well until clear solution
Step 2: For I.V use: Add 5ml Sodium Chloride Injection 0.9% in the vial (Step 1) & mix well & use by slow I.V route over 2-3 minutes (Do not put the solution in an I.V drip).
For I.M use: Add 2ml Sodium Chloride Inj. 0.9% in vial (Step 1) & mix again & use by I.M route.
Gen-M 120mg for Injection:
Step 1: Add 2ml Sodium Bicarbonate Inj. 5% in vial & mix well until clear solution.
Step 2: For I.V use: Add 10ml Sodium Chloride Inj. 0.9% in the vial (Step 1), mix well & use by slow I.V route over 2-3 minutes (Do not put the solution in an I.V drip).
For I.M use:
Add 4ml Sodium Chloride Inj. 0.9% in the vial (Step 1), mix again & use by I.M route.
Children
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Age 7 years or more same as adult dose
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Below 7 years: 1.5 mg/kg
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In both the age groups children should be given the second dose after 4-6 hours then one dose after every 24 hours once a day.
Pregnancy and Lactation
Parenteral Gen-M 30mg Ampule 2 ml should be used for the treatment of severe falciparum malaria only where there is evidence that the antimalarial efficacy of quinine is declining. Gen-M 30mg Ampule 2 ml should not be used during the first trimester of pregnancy. The effect of Gen-M 30mg Ampule 2 ml on lactation is undetermined and precaution is advised.
Contraindications
Inform your doctor if you have a history of any of the following before using Gen-M 30mg Ampule 2 ml:
- Hypersensitivity to Gen-M 30mg Ampule 2 ml or its active ingredients
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Electrolyte disturbances
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Concomitant use with other drugs that cause QT-interval prolongation
Precautions
Inform your doctor about any of the following conditions before using Gen-M 30mg Ampule 2 ml
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If you are pregnant or breastfeeding
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Post-treatment hemolysis
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History of arrhythmias
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Clinical bradycardia
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Congestive heart failure
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Reduced ventricular ejection fraction
Interactions With Other Medications
Inform your doctor about the use of the following before using Gen-M 30mg Ampule 2 ml
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Antioxidant drugs e.g., vitamin E, C
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UGT inhibitors e.g., axitinib, vandetanib, imatinib, diclofenac.
Adverse Effects
Like most medicines,Gen-M 30mg Ampule 2 ml has certain side effects which include
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Transient and reversible reticulocytopenia
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Severe hemolytic anemia
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Renal failure
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Jaundice
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Drug fever
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Rashes
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Bradycardia
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Transient first-degree heart block
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Transient and reversible elevation of serum transaminases
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Nausea
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Abdominal pain
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Diarrhea
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Headache
How To Cope with Adverse Effects
Nausea- To avoid nausea, take simple and small meals. Avoid rich and spicy food items. Rather than one large meal takes several small ones. Avoid high sugar content foods.
Headache- Drink plenty of water and fluids and ask your doctor for a painkiller. If the headaches persist, then contact your doctor.
Constipation- Eat a well-balanced diet and drink plenty of water to avoid constipation. Add fiber to the diet to avoid constipation.
Anemia- Pale skin, fatigue, weakness, and disturbed appetite are signs of anemia. To cope with anemia, eat iron-rich food such as beef, salmon, cereals, liver, dry fruits, and leafy vegetables. Take a good night’s sleep, take rest when needed to avoid fainting, and light exercise daily improves blood flow. Your doctor might order a blood screening test. Severe conditions may require blood transfusions.
Drug-induced fever- At time Gen-M 30mg Ampule 2 ml causes fever. Take an over-the-counter antipyretic. If fever persists, contact your doctor.
FAQs
Q. WHAT IS {{PRODUCT}} USED FOR?
Gen-M 30mg Ampule 2 ml is used to treat malaria in children and adults.
Q. IN WHICH FORM IS {{PRODUCT}} AVAILABLE?
{{PRODUCT}} is available in injection form.
Q. HOW IS {{PRODUCT}} TAKEN?
{{PRODUCT}} is injected intravenously or intramuscularly.
Q. WHAT HAPPENS WHEN {{PRODUCT}} OVERDOSAGE OCCURS?
Do not use Gen-M 30mg Ampule 2 ml more than the prescribed dose. Taking more quantity of Gen-M 30mg Ampule 2 ml will not improve your symptoms rapidly rather they may cause poisoning or serious side effects.
Q. WHAT HAPPENS WHEN YOU FORGET TO TAKE {{PRODUCT}}?
In case you miss a dose, take it as soon as you remember. Do not take two doses in one day.
Q. HOW LONG DOES {{PRODUCT}} TAKE TO START WORKING?
Gen-M 30mg Ampule 2 ml is a rapidly acting drug. It is absorbed quickly and starts its work rapidly. Its half-life is 1.8 hours.
Q. HOW SHOULD {{PRODUCT}} BE STORED?
Keep Gen-M 30mg Ampule 2 ml out of the reach of children. Store Gen-M 30mg Ampule 2 ml at room temperature and away from heat and direct light. Do not use Gen-M 30mg Ampule 2 ml after expiry date. After reconstitution if Gen-M 30mg Ampule 2 ml becomes cloudy then discard it.
Q. CAN I DRIVE OR RIDE A BIKE AFTER TAKING {{PRODUCT}}?
You should not drive or use machinery after the use of Gen-M 30mg Ampule 2 ml if you experience drowsiness, dizziness, or headache.
Additional information
Type | Ampule – Injection |
---|---|
Feature | 30mg |
Unit | ml |
Formula | Artesunate |
Composition | Artesunate 30 mg |
Brand | Genix Pharma |
Prescription Required | Yes |