Misonate 120mg Injection 1 vial

Description

About

Misonate 120mg Injection 1 vial belongs to a group of medicines called antimalarials. Misonate 120mg Injection 1 vial is used for the initial treatment of severe malaria. Misonate 120mg Injection 1 vial comes in injection form. It can be used in adults and children. 

Misonate 120mg Injection 1 vial is an artemisinin derivative. Misonate 120mg Injection 1 vial hinders the normal function of Plasmodium parasites. Misonate 120mg Injection 1 vial has a short duration of action due to its short life. Misonate 120mg Injection 1 vial may cause side effects such as renal failure, hemoglobinuria, and jaundice. 

Indications

Misonate 120mg Injection 1 vial can be used for:

• Initial treatment of severe malaria

• Cerebral malaria

• Second-line treatment in chloroquine-resistant falciparum malaria

How Does Misonate 120mg Injection 1 vial Work

Misonate 120mg Injection 1 vial is an antimalarial drug. Misonate 120mg Injection 1 vial is an artemisinin derivative that is rapidly metabolized to active dihydroartemisinin. Dihydroartemisinin generates free radicals to inhibit the normal function of plasmodium parasites.  

How To Use Misonate 120mg Injection 1 vial

Misonate 120mg Injection 1 vial comes in injection form. Misonate 120mg Injection 1 vial can be given via intramuscular or intravenous route. For the IM route dissolve the product with 1 mL of 5% sodium bicarbonate and inject. For slow IV infusion, dissolve Misonate 120mg Injection 1 vial with 1 mL of 5% sodium bicarbonate and add 5 mL of 0.9% sodium chloride and inject. Injection should be injected immediately, if the solution appears cloudy or sedimentation occurs the injection should be rejected. 

Dosage

The recommended dosage:

Adults

Severe malaria

2.4mg/Kg at 0, 12, and 24 hours then 2.4mg/Kg daily for up to 7 days. 

Reconstitution Method Gen-M 30mg for Injection

Step 1: Add 0.5ml Sodium Bicarbonate Inj. 5% in vial & mix well until clear solution. Step 2: For I.V use: Add 2.5ml Sodium Chloride Inj. 0.9% in the vial (Step 1) & mix well & use by slow I.V route over 2-3 minutes (Do not put the solution in an I.V drip).

For I.M use 

Add 1 ml Sodium Chloride Inj. 0.9% in vial (Step 1) & mix again & use by I.M route. 

Gen-M 60mg for Injection

Step 1: Add 1ml Sodium Bicarbonate Inj. 5% in vial & mix well until clear solution

Step 2: For I.V use: Add 5ml Sodium Chloride Injection 0.9% in the vial (Step 1) & mix well & use by slow I.V route over 2-3 minutes (Do not put the solution in an I.V drip). 

For I.M use: Add 2ml Sodium Chloride Inj. 0.9% in vial (Step 1) & mix again & use by I.M route. 

Gen-M 120mg for Injection:

Step 1: Add 2ml Sodium Bicarbonate Inj. 5% in vial & mix well until clear solution. 

Step 2: For I.V use: Add 10ml Sodium Chloride Inj. 0.9% in the vial (Step 1), mix well & use by slow I.V route over 2-3 minutes (Do not put the solution in an I.V drip). 

For I.M use: 

Add 4ml Sodium Chloride Inj. 0.9% in the vial (Step 1), mix again & use by I.M route.

Children

• Age 7 years or more same as adult dose

• Below 7 years: 1.5 mg/kg

• In both the age groups children should be given the second dose after 4-6 hours then one dose after every 24 hours once a day.

Pregnancy and Lactation

Parenteral Misonate 120mg Injection 1 vial should be used for the treatment of severe falciparum malaria only where there is evidence that the antimalarial efficacy of quinine is declining. Misonate 120mg Injection 1 vial should not be used during the first trimester of pregnancy. The effect of Misonate 120mg Injection 1 vial on lactation is undetermined and precaution is advised. 

Contraindications

Inform your doctor if you have a history of any of the following before using Misonate 120mg Injection 1 vial:

• Hypersensitivity to Misonate 120mg Injection 1 vial or its active ingredients

• Electrolyte disturbances

• Concomitant use with other drugs that cause QT-interval prolongation

Precautions

Inform your doctor about any of the following conditions before using Misonate 120mg Injection 1 vial

• If you are pregnant or breastfeeding

• Post-treatment hemolysis

• History of arrhythmias

• Clinical bradycardia

• Congestive heart failure

• Reduced ventricular ejection fraction

Interactions With Other Medications

Inform your doctor about the use of the following before using Misonate 120mg Injection 1 vial

• Antioxidant drugs e.g., vitamin E, C

• UGT inhibitors e.g., axitinib, vandetanib, imatinib, diclofenac.

Adverse Effects

Like most medicines,Misonate 120mg Injection 1 vial has certain side effects which include

• Transient and reversible reticulocytopenia

• Severe hemolytic anemia

• Renal failure

• Jaundice 

• Drug fever

• Rashes

• Bradycardia

• Transient first-degree heart block

• Transient and reversible elevation of serum transaminases

• Nausea

• Abdominal pain

• Diarrhea

• Headache 

How To Cope with Adverse Effects

Nausea- To avoid nausea, take simple and small meals. Avoid rich and spicy food items. Rather than one large meal takes several small ones. Avoid high sugar content foods. 

Headache- Drink plenty of water and fluids and ask your doctor for a painkiller. If the headaches persist, then contact your doctor.

Constipation- Eat a well-balanced diet and drink plenty of water to avoid constipation. Add fiber to the diet to avoid constipation. 

Anemia- Pale skin, fatigue, weakness, and disturbed appetite are signs of anemia. To cope with anemia, eat iron-rich food such as beef, salmon, cereals, liver, dry fruits, and leafy vegetables. Take a good night’s sleep, take rest when needed to avoid fainting, and light exercise daily improves blood flow. Your doctor might order a blood screening test. Severe conditions may require blood transfusions.

Drug-induced fever- At time Misonate 120mg Injection 1 vial causes fever. Take an over-the-counter antipyretic. If fever persists, contact your doctor. 

FAQs

Q. WHAT IS {{PRODUCT}} USED FOR?

Misonate 120mg Injection 1 vial is used to treat malaria in children and adults. 

Q. IN WHICH FORM IS {{PRODUCT}} AVAILABLE?

{{PRODUCT}} is available in injection form.

Q. HOW IS {{PRODUCT}} TAKEN?

{{PRODUCT}} is injected intravenously or intramuscularly. 

Q. WHAT HAPPENS WHEN {{PRODUCT}} OVERDOSAGE OCCURS?

Do not use Misonate 120mg Injection 1 vial more than the prescribed dose. Taking more quantity of Misonate 120mg Injection 1 vial will not improve your symptoms rapidly rather they may cause poisoning or serious side effects.

Q. WHAT HAPPENS WHEN YOU FORGET TO TAKE {{PRODUCT}}?

In case you miss a dose, take it as soon as you remember. Do not take two doses in one day.

Q. HOW LONG DOES {{PRODUCT}} TAKE TO START WORKING?

Misonate 120mg Injection 1 vial is a rapidly acting drug. It is absorbed quickly and starts its work rapidly. Its half-life is 1.8 hours.

Q. HOW SHOULD {{PRODUCT}} BE STORED?

Keep Misonate 120mg Injection 1 vial out of the reach of children. Store Misonate 120mg Injection 1 vial at room temperature and away from heat and direct light. Do not use Misonate 120mg Injection 1 vial after expiry date. After reconstitution if Misonate 120mg Injection 1 vial becomes cloudy then discard it.

Q. CAN I DRIVE OR RIDE A BIKE AFTER TAKING {{PRODUCT}}?

You should not drive or use machinery after the use of Misonate 120mg Injection 1 vial if you experience drowsiness, dizziness, or headache.