Nuzib 100mg Capsule 10 ‘S

Description

About

Nuzib 100mg Capsule 10 ‘S belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAID) which are used for moderate to severe pain relief alone or in combination. It also helps in combating signs of inflammation including swelling, stiffness, tenderness, and pain in conditions such as osteoarthritis, rheumatoid arthritis, dysmenorrhea, juvenile rheumatoid arthritis, and muscle pain.  

Nuzib 100mg Capsule 10 ‘S is chemically composed of Celecoxib, which particularly inhibits COX-2, unlike other NSAIDs that are non-specific inhibitors of COX 1 and 2. These work by blocking inflammatory mediators and reducing pain and swelling. NSAIDs carry an increased risk of side effects on gastrointestinal including ulceration, bleeding, etc. Nuzib 100mg Capsule 10 ‘S must not be prescribed to people with long-standing heart disease due to the potential risk of myocardial infarction.

Nuzib 100mg Capsule 10 ‘S is available in form of capsules to be taken orally or as prescribed by the doctor. Commonly it is prescribed once or twice a day, to be taken with or without food. Alternatively, powdered medicine filled in the capsule can be emptied on food if you have difficulty swallowing the entire capsule. Nuzib 100mg Capsule 10 ‘S is not safe to be used in children under 18 years of age and pregnant women. The most common side effects of Nuzib 100mg Capsule 10 ‘S include diarrhea, nausea, fatigue, and abdominal pain. Kindly note it can cause serious complications if taken more than the safe dose. Overdosing or unmonitored self-medication can cause serious side effects. Even in case of severe pain, do not double the dose or increase the prescribed dosage without a doctor’s consultation.

Indications

Nuzib 100mg Capsule 10 ‘S is prescribed to adults above 18 years of age to treat pain and swelling due to: 

• Rheumatoid arthritis
• Juvenile rheumatoid arthritis
• Osteoarthritis 
• Ankylosing spondylitis 
• Dysmennhorhea 

How does Nuzib 100mg Capsule 10 ‘S work

Nuzib 100mg Capsule 10 ‘S works by blocking the production of prostaglandins, a major group of chemicals involved in inflammation. Prostaglandins are naturally occurring substance in the body that helps carry out inflammatory responses in the body when needed. By preventing prostaglandins from carrying out the inflammatory process, Nuzib 100mg Capsule 10 ‘S can in the reduction of inflammation, swelling, and pain experienced by the patient.

How To Use Nuzib 100mg Capsule 10 ‘S

Nuzib 100mg Capsule 10 ‘S is available in form of capsules to be taken orally by swallowing, once or twice daily, or as directed by the doctor. It is advised to have Nuzib 100mg Capsule 10 ‘S with food if it causes an upset stomach. If you find it difficult to swallow the capsule, you can open the capsule and empty contents in your food of semi-solid consistency such as porridge, cereal, mashed potato/ banana, or yogurt, and eat it. Nuzib 100mg Capsule 10 ‘S may have to be taken twice a day, in which case the patient is advised to take the doses at the same time each day to ensure sustained levels of medicine in your body.

If you miss a dose of the medication, make sure you take it as soon as possible on that same day. If you don’t remember you missed the dose until the next dose time or the next day, do not double the dose and take your medication as per schedule. Nuzib 100mg Capsule 10 ‘S must be used with caution in patients with gut and heart problems. 

Available form and potency

Capsule – 100 mg

Capsule – 200 mg

Dosage

It is advised to start the treatment with a minimally effective dose, to be increased up to 400 mg if needed (do not take more than 400 mg). Please consult your doctor at once if there is no noticeable difference in your symptoms. 

Adult Dosage

These doses are generally recommended for the following conditions:

Rheumatoid arthritis: 100 – 200 mg, twice daily

Osteoarthritis: 100 mg twice a day, or 200 mg once a day

Ankylosing spondylitis: 100 mg twice a day, or 200 mg once a day

Dysmenorrhea: 200 mg twice daily, may be increased

Acute Pain: 400 mg once as starting dose, lower the dose to 200 mg twice a day

Pediatric Dose

Nuzib 100mg Capsule 10 ‘S is not prescribed to children and adolescents under 18 years of age

Elderly Dose

Doses must be adjusted when treating the elderly population (above 65 years of age). Moreover, Nuzib 100mg Capsule 10 ‘S is processed majorly by the liver, therefore while administering the drug to elderly patients careful consideration must be given to liver and renal function while deciding upon the dose, especially if the elderly are underweight (less than 50 kgs). 

Pregnancy Use And Lactation

 Nuzib 100mg Capsule 10 ‘S is classified as a pregnancy category C (up to 3rd trimester)) and D (towards the end of the 3rd trimester) drug meaning there is an increased risk of harmful effects to the fetus, it is known to cause heart defects in babies. If you are pregnant, think you may be pregnant, or are planning to conceive a baby, please do not use it before consulting your doctor before using Nuzib 100mg Capsule 10 ‘S. If it is accessary to take Nuzib 100mg Capsule 10 ‘S, your doctor may advise you to start contraception. 

Nuzib 100mg Capsule 10 ‘S is also secreted in human milk in minute quantity, if you are breastfeeding, please consult your doctor before taking Nuzib 100mg Capsule 10 ‘S. 

Contraindications

Please tell your doctor if you have a history of any of the following before using Nuzib 100mg Capsule 10 ‘S:

• Allergy to Nuzib 100mg Capsule 10 ‘S or similar drugs or sulfonamide antibiotics 
• Asthmatics (aspirin associated asthma)
• Gastrointestinal bleeding/perforation
• Gastric ulceration 
• Inflammatory disease of the gut like colitis, Crohn’s disease
• Severe kidney impairment/ failure
• Severe liver impairment/ failure
• Chronic heart disease 
• History of or a scheduled Coronary Artery Bypass Graft surgery
• Pregnancy 

Precautions

Please tell your doctor about any of the following conditions before using Nuzib 100mg Capsule 10 ‘S

• Asthmatic patients should avoid taking Nuzib 100mg Capsule 10 ‘S without medical supervision
• Mild to moderate heart condition may aggravate without any forewarning signs, make sure to consult a doctor first before taking Nuzib 100mg Capsule 10 ‘S
• NSAIDs are likely to elevate blood pressure, it is advised to monitor your B.P when taking Nuzib 100mg Capsule 10 ‘S
• If you have a history of ulcers or bleeding ulcers, inform your doctor first before using the drug
• If you are taking blood thinners like warfarin, monitor your PT, carefully it may increase your chance to bleed
• Use of other regular NSAIDs like ibuprofen, and naproxen should be avoided concurrently with Nuzib 100mg Capsule 10 ‘S
• Please be careful if you have diabetes, hypercholesterolemia or you are a heavy smoker
• Alcohol consumption must be avoided with Nuzib 100mg Capsule 10 ‘S
• When treating elderly patients with Nuzib 100mg Capsule 10 ‘S, the dosage is set carefully to avoid side effects
• In case of a pregnancy, or if you are planning to conceive a baby/ breastfeeding before starting Nuzib 100mg Capsule 10 ‘S always ask your doctor first

Interactions With Other Medications

Few medicines can interact with Nuzib 100mg Capsule 10 ‘S some of which are enlisted below. Please tell your doctor about the use of the following before using Nuzib 100mg Capsule 10 ‘S:

• Anticoagulants like warfarin, apixaban 
• Methotrexate
• ACE Inhibitors like enalapril
• Sulphonamides
• Diuretics
• Lithium
• Cyclosporin
• SSRIs
• Other NSAIDs
• Neuroleptics
• Carbamazepine
• Barbiturates 
• Dextromethorphan 
• Fluconazole 
• Rifampicin 
• Digoxin

Adverse Effects

Common Adverse Effects

Like most medicinesNuzib 100mg Capsule 10 ‘S has certain side effects which include:

• Stomach problems (nausea, vomiting, diarrhea)
• Flatulence 
• Dizziness 
• Heartburn
• Fatigue  

These effects tend to be mild and resolve in a few days of taking Nuzib 100mg Capsule 10 ‘S.

Rare Adverse Effects

If any of the following adverse effects are seen or felt, the patient is advised to immediately contact their doctor

• Anaphylactic Reaction
• Tachycardia 
• Difficulty in breathing 
• Swelling of ankles/feet (peripheral edema)
• Difficulty swallowing
• High blood pressure 
• Yellowing of eyes and skin 
• Skin rash
• Blisters 
• Weight gain 
• Painful urination 
• Back pain 

LIST OF HOW TO DEAL WITH ADVERSE EFFECTS.

• Fatigue – Patients experiencing this adverse effect, are advised to take deep breaths, intake tea or coffee, get a good night’s rest, and not overburden themselves for a few days.
• Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
• Feeling or being sick (nausea or vomiting) or diarrhea – Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water.
• Feeling dizzy (lightheaded) or weak – If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.
• Heartburn – This can be dealt with by chewing on mint-flavored gum that’ll help neutralize the acid in the body. Standing up straighter, adding ginger to the daily diet, elevating the patient’s upper body, and having licorice supplements has shown to provide relief.
• Skin Rash – This can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. An antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.
• Flu-like symptoms – To manage symptoms, patients are advised to drink plenty of fluids and get plenty of rest and sleep. Take an antihistamine, a nasal decongestant, or a lozenge to feel better when needed.
• Redness Of The Skin – This can be combated by applying a cold pack to the affected area.

FAQ’s

#1. What Lab Tests Will Be Prescribed While Treatment With Nuzib 100mg Capsule 10 ‘S and How Often?

Kidney and liver function tests along with blood tests to keep a check on LFTs, Creatinine Levels, PT, hematocrit, and hemoglobin are advised to be done periodically. It is also advised that patients learn to monitor their blood pressure levels daily from the comfort of their homes and inform their doctor of any changes seen.

#2. Is It Safe To Have Antacids For Indigestion Along With Nuzib 100mg Capsule 10 ‘S?

Yes, Antacids are safe to be ingested by the patient while undergoing treatment with Nuzib 100mg Capsule 10 ‘S. But take your antacid drug 2 hours before or after you take Nuzib 100mg Capsule 10 ‘S. 

#3. Is It Safe To Have Nuzib 100mg Capsule 10 ‘S Along With Other Painkillers?

Over-the-counter analgesics like paracetamol are safely taken with Nuzib 100mg Capsule 10 ‘S. However, do not take aspirin, ibuprofen, naproxen, or diclofenac-based analgesics as these might increase the risk of Gl bleeding. 

#4. Can I Drive After Taking This Medication?

This medication, in general, is not known to make you dizzy but, if that happens kindly avoid driving or operating any heavy or sharp machinery.

#5. WHAT ARE COMMON SIDE EFFECTS CAUSED BY Nuzib 100mg Capsule 10 ‘S?

• Stomach problems (nausea, vomiting, diarrhea)
• Flatulence 
• Dizziness 
• Heartburn 

#6.HOW TO STORE Nuzib 100mg Capsule 10 ‘S?

Nuzib 100mg Capsule 10 ‘S is to be kept away from the reach of children, in a cool dry place away from direct sunlight and humidity as that tends to ruin certain drugs.

#7.CAN Nuzib 100mg Capsule 10 ‘S CAUSE DIZZINESS? IF SO, HOW SHOULD I MANAGE IT?

Yes, in general, it does not cause dizziness but if this happens, you should sit or lie down until the symptoms pass. However, please note this is temporary and usually goes away as the treatment continues. It is also advised to avoid the consumption of alcohol during the treatment, as it may worsen the dizziness.

#9. Will Nuzib 100mg Capsule 10 ‘S Affect My Fertility?

Nuzib 100mg Capsule 10 ‘S may disturb your fertility making it difficult to get pregnant, if this happens consult your doctor right away

#10. How Is Nuzib 100mg Capsule 10 ‘S Supposed To Be Taken?

Nuzib 100mg Capsule 10 ‘S is to be ingested once or twice daily by mouth. Nuzib 100mg Capsule 10 ‘S is advised to be ingested with food as it may cause an upset stomach. If you find it difficult to swallow the capsule, you can open the capsule and empty its contents in your food of semi-solid consistency such as porridge, cereal, mashed potato/ banana, or yogurt and eat it.

#11. Will Nuzib 100mg Capsule 10 ‘S Cause Me To Gain Weight?

As a part of its side effects Nuzib 100mg Capsule 10 ‘S may cause you to gain weight or cause edema and water retention in your body. You should immediately consult a doctor if this happens