Preglan-E2 3mg Tablet 1 ‘S

Description

About

The process of human development and childbirth is a uniquely navigated stepwise process stretching over 9 months, starting with conception. As the time for delivery draws near a lot of physical and physiological changes come into play to help deliver the baby out of the mother’s womb. One of the most important changes is called “Cervical ripening” specifically referring to opening (widening) of the cervix to give a passage to the baby. This happens at the very end of pregnancy when the baby is ready to be born. If widening of the cervix is delayed or does not occur at the due time it can be induced with help of a variety of artificial methods.  Preglan-E2 3mg Tablet 1 ‘S is a potent drug that belongs to a class of medicines called Prostaglandin E2. Preglan-E2 3mg Tablet 1 ‘S can be used to promote the cervical opening, alternatively, this can also be utilized for removing fetal remnants after abortion or death of a fetus, from the uterus. 

Preglan-E2 3mg Tablet 1 ‘S is chemically composed of Dinoprostone, whose exact mechanism of action is not known, however, it is thought to directly exert muscular contractions within the uterus housing the fetus/ unborn baby. Several functions attributed to Prostaglandin E2 include calcium ion transport and cAMP in uterine smooth muscles, bringing about the breakdown of collagen by collagenase secretion and leading to events that eventually help widen the cervix for natural birth. Preglan-E2 3mg Tablet 1 ‘S is a prescription exclusive medicine and must not be used otherwise.  Certain prerequisites must be checked first by a midwife or your obstetrician to ensure the validation of using Preglan-E2 3mg Tablet 1 ‘S. 

Preglan-E2 3mg Tablet 1 ‘S is available in the form of tablets to be placed high up in the vagina by a healthcare professional or a midwife. In general, not more than 2 tablets in 24 hours are used, given 6 hours apart to stimulate labor. The patient is asked to lie down for 2 hours minimum. If contractions do not occur, alternative methods may be used for the said purpose. Preglan-E2 3mg Tablet 1 ‘S is only given after full-term or when the time of labor is near for encouraging natural birth. In the meanwhile, condition of the mother and unborn baby, are monitored carefully for the first 30 minutes at least and periodically afterward. Once contractions begin as evident by some sign, call your medical attendant immediately who will help you remove the tablet. Some of the common side effects include nausea, vomiting, chills, back pain, vaginal pain, etc.

Indications

Preglan-E2 3mg Tablet 1 ‘S is prescribed to pregnant females too:

• Induce labor
• Empty uterus of fetal remnants after abortion or death of a fetus

How does Preglan-E2 3mg Tablet 1 ‘S work?

Preglan-E2 3mg Tablet 1 ‘S is chemically composed of Dinoprostone, whose exact mechanism of action is not known, however, it is thought to directly exert muscular contractions within the uterus housing the fetus/ unborn baby. Several functions attributed to Prostaglandin E2 include calcium ion transport and cAMP in uterine smooth muscles, bringing about the breakdown of collagen via collagenase secretion and leading to events that eventually help widen the cervix for natural birth to take place.

How to use Preglan-E2 3mg Tablet 1 ‘S?

Preglan-E2 3mg Tablet 1 ‘S is available in the form of tablets meant to be used as an intravaginal “insert”. Tablets are packaged in foil which should only be opened right before use. Do not take it by mouth, instead, your obstetrician will assess if you meet certain requirements for this medicine to be used. Once ensured, the patient is asked to lie down, and the tablet is placed high up in the vagina (posterior fornix). The patient must keep lying down for at least 1 to 2 hours after insertion. For the next 30 minutes, the conditions of the baby and mother are monitored carefully, and CTG machines and BP measuring devices are used to check the status and periodically afterward. Patients must report any signs of labor (contractions, bleeding, pain, etc. ) immediately to the medical attendant. If no contractions occur, another tablet can be placed intravaginally after a period of 6 to 8 hours. Preglan-E2 3mg Tablet 1 ‘S must be removed if contractions start or before placing the second tablet. A retrieval system may or may not be employed to help place and remove the tablet, carefully read the package leaflet. 

Available Potency of Preglan-E2 3mg Tablet 1 ‘S 

• 3 mg –   Tablets

Dosage

Adult Dose

1 tablet is to be placed intravaginally, in case of no signs of labor keep 1 more tablet after 6 to 8 hours

Maximum Dose: 6 mg in 24 hours 

Child Dose

Not recommended in this age group

Elderly Dose

Preglan-E2 3mg Tablet 1 ‘S is only prescribed to pregnant females of fertile age group

Pregnancy use and lactation

Preglan-E2 3mg Tablet 1 ‘S is classified as a pregnancy category C drug by FDA and should only be used at the end of the pregnancy period to help induce labor. Do not use without a doctor’s supervision while expecting or breastfeeding a baby.

Contraindications

Please inform your doctor if you have a history of any before using Preglan-E2 3mg Tablet 1 ‘S:

• Allergic reaction to Preglan-E2 3mg Tablet 1 ‘S or similar drugs
• Severe Liver disease 
• Multiple pregnancies 
• Unusual vaginal bleeding
• Abnormalities in fetal heart rate/ condition
• When a cesarean section is needed  such as in case of birth canal infections
• Obstetric emergencies 
• Breech (non-vertex) position 
• High risk/complicated pregnancy
• History of previous uterine surgery 
• Epilepsy 

Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Preglan-E2 3mg Tablet 1 ‘S:‌ ‌

• Make sure to rule out any allergies to  ‌Preglan-E2 3mg Tablet 1 ‘S or any similar drug
• Compromised liver function can negatively affect your body since ‌Preglan-E2 3mg Tablet 1 ‘S is largely processed in it, discuss it with your doctor
• Conditions like asthma or chronic lung disease should be considered before giving  Preglan-E2 3mg Tablet 1 ‘S
• Preglan-E2 3mg Tablet 1 ‘S has been reported to have caused glaucoma in some susceptible patients, discuss with your doctor
• A CTG machine is usually attached to the patient for continued monitoring of the baby’s heart rate, as well as the mother’s heart rate and blood pressure regulation
• Make sure to have a bell accessible to the patient in case she might observe signs of labor or worsened symptoms, to call for medical help
• Preglan-E2 3mg Tablet 1 ‘S can cause powerful contractions, and there is a risk of uterine rupture which must be discussed with the patient
• Expecting mothers with age above 35 or 40 years are at greater risk of developing post-delivery complications such as DIC, due countermeasures must be in place in case of emergency 
• Patient is advised to take a warm bath and use the restroom ahead of placing medicine, for it requires 1 to 2 hours of immobility after insertion
• Medical conditions like epilepsy, kidney, and others must always be taken into account before inducing the labor

Interaction with other medications

Certain medications could interact with Preglan-E2 3mg Tablet 1 ‘S and may increase or decrease its absorption, in which case, your doctor might alter your dosage. A few of these interacting drugs are given below:

• Oxytocin 
• Epinephrine 
• Articaine 
• Enflurane 
• Halothane 
• Carboprost tromethamine
• Ergonovin
• Prilocaine 

Adverse effects

Like most medicines, Preglan-E2 3mg Tablet 1 ‘S has some side effects which include:

Common Side effects

• Nausea
• Vomiting  
• Headache 
• Backache 
• Bleeding 
• Fever /chills 
• Sweating 

Rare side effects

• Anaphylactic reaction 
• Vaginal pain 
• Vaginal bleeding 
• Fetal heart rate fluctuation 
• Low blood pressure 
• Heart rate irregularities 
• Uterine rupture 
• Cervical tear/damage 
• DIC 
• Amniotic fluid embolism 
• Chest pain 
• Wheezing 
• Breathing difficulties 

LIST OF HOW TO DEAL WITH ADVERSE EFFECTS

All of the side effects should be addressed by a medical attendant with due attention. Call a nurse or your obstetrician if you feel any of the side effects.

FAQs

#1. WHAT EXACTLY DOES Preglan-E2 3mg Tablet 1 ‘S DO?

Preglan-E2 3mg Tablet 1 ‘S is used as an aid in the last stages of childbirth after pregnancy term or when the baby needs to be delivered. It causes widening of the passage for baby’s delivery and enhances contractions.

#2. HOW LONG DOES IT TAKE FOR Preglan-E2 3mg Tablet 1 ‘S TO START WORKING?

The onset of action of Preglan-E2 3mg Tablet 1 ‘S can start any time after an hour of placement up to a day depending on different factors. If contractions do not occur, another tablet of Preglan-E2 3mg Tablet 1 ‘S can be inserted after a waiting period of 6 to 8 hours, not exceeding a total of 6 mg in a day.

#3. WHAT IF I TAKE TOO MUCH OF Preglan-E2 3mg Tablet 1 ‘S?

Preglan-E2 3mg Tablet 1 ‘S is only given by a midwife or healthcare professional in a healthcare facility, lacking any prescribed course so there is a rare chance that it can lead to an overdose. If more than the required dose is taken, healthcare professionals will assist you. 

#4. HOW SHOULD Preglan-E2 3mg Tablet 1 ‘S BE STORED?

Store it in a refrigerator, away from excess heat, direct sunlight, and moisture. Make sure it is not consumed by pets, children, and other people. The storing temperature must be maintained at 2 to 8 °C.

#5. CAN I DRINK ALCOHOL WITH Preglan-E2 3mg Tablet 1 ‘S?

Preglan-E2 3mg Tablet 1 ‘S is given at the end of pregnancy term, it must not be consumed due to well documented adverse effects.

#6. CAN I MOVE ABOUT AFTER INSERTION OF Preglan-E2 3mg Tablet 1 ‘S?

After placement of Preglan-E2 3mg Tablet 1 ‘S it is advised to keep in a lying position for at least 2 hours, moving about or getting up too soon can result in displacement of tablet from the cervix.

#7. WILL I HAVE TO UNDERGO ANY TEST(S) WHILE UNDER TREATMENT WITH Preglan-E2 3mg Tablet 1 ‘S?

Before using Preglan-E2 3mg Tablet 1 ‘S, your obstetrician or midwife will perform a physical examination, as well as monitor your blood pressure and other indicators, CTG will be done to monitor the baby’s heart rate. After placement of Preglan-E2 3mg Tablet 1 ‘S for the first 30 to 45 minutes, monitoring of BP and CTG will be repeated to assess the response and periodically afterward, till signs of labor appear.