Piozer 15mg Tablet 7 ‘S

Description

About

Piozer 15mg Tablet 7 ‘S is an oral antidiabetic medication that is used to manage type 2 diabetes. Type-2 diabetes is non-insulin-dependent diabetes in which the insulin produced by the pancreas is less effective because the body doesn’t recognize it. Piozer 15mg Tablet 7 ‘S being an oral antidiabetic agent, decreases insulin resistance and renders the body make beneficial use of insulin in controlling diabetes. 

Piozer 15mg Tablet 7 ‘S can be worsening in people with heart failure. Tell your doctor if you had congestive or any other type of heart failure in the past before starting the treatment with Piozer 15mg Tablet 7 ‘S. Watch for symptoms like shortness of breath, edema, sudden weight gain, swollen ankles, tiredness, etc., after the initiation of treatment with Piozer 15mg Tablet 7 ‘S. 

Lifestyle changes are advised along with the intake of Piozer 15mg Tablet 7 ‘S, as exercise and proper diet play a role in controlling high blood sugar. Piozer 15mg Tablet 7 ‘S on the other hand, acts by restoring the body’s response to insulin and helps lowering blood sugar by making the pancreatic insulin useful. Piozer 15mg Tablet 7 ‘S is often prescribed in combination with other oral antidiabetic agents such as glyburide, metformin, and sulfonylureas, depending on a person’s response to the treatment of hyperglycemia. 

Indications

Piozer Tablet is indicated in the individuals with type 2 diabetes as: 

• An adjunct to exercise and diet to enhance the body’s glycemic control 
• Monotherapy, specifically in overweight patients in which exercise and diet are not enough. Also, to whom Metformin is contraindicated or intolerant.
• Combination with metformin (dual therapy) for glycemic control or with sulfonylureas if Metformin is contraindicated or intolerant. 
• Triple therapy in combination with Sulphonylureas and Metformin in overweight patients who have insufficient glycemic control even despite the dual combination therapy with oral antidiabetic agents.  
• Combination with insulin when glycemic control is not sufficient in patients who are on insulin. 

How Does Piozer 15mg Tablet 7 ‘S Work?

Piozer Tablet contains the active ingredient Pioglitazone which is responsible for causing insulin tissue sensitivity. Adipose tissue, skeletal muscles, and liver are the target sites for insulin’s action. These sites have Peroxisome proliferator-activated receptor gamma (PPARγ) that is involved in the insulin response. Piozer Tablet acts as a selective agonist to peroxisome proliferator-activated receptor gamma (PPARγ) at these insulin-acting sites and increases insulin-responsive genes transcription.

These insulin-responsive genes are involved in controlling the production, transport, and utilization of lipids and glucose. This way, the active ingredient – pioglitazone increases tissue sensitivity and decreases hepatic production of glucose. This improves type 2 diabetes-associated insulin resistance without abnormal insulin secretion by the beta cells of the pancreas. 

How To Use Piozer 15mg Tablet 7 ‘S?

Piozer Tablet is either used alone or in combination with other antidiabetic agents such as metformin, glyburide, and sulfonylureas. Piozer Tablet  should be taken orally (by mouth) without regard to a meal.

Dosage

The active ingredient – Pioglitazone comes as an insulin sensitizer with the following strengths:

• 15mg tablet 
• 30mg tablet
• 45mg tablet 

Adult Dose

Type 2 Diabetes Mellitus

• As monotherapy or in combination with insulin or insulin secretagogue: 15 to 30 mg once daily with a meal. The dose can be increased by 15 mg with careful monitoring but should not exceed more than 45mg once a day (whether it’s monotherapy or combination therapy). ALT (liver enzyme) should be monitored upon initiation of the therapy. The treatment continues once a month for 12 months, and then after every three months. 

The dose of insulin is decreased by 10 to 25% when administered with insulin if the patient has hypoglycemia or if the blood glucose levels go below 100mg/dL. The dose of insulin secretagogue (e.g. metformin, sulfonylurea) is decreased when administered in combination with these agents if the patient reports hypoglycemia. 

Pediatric Dose

Piozer Tablet is not indicated for use in children.

Pregnancy And Lactation

The mechanism of action of Piozer 15mg Tablet 7 ‘S is not clear in pregnant women, neither the active component is known to be secreted in human milk. Therefore, Piozer 15mg Tablet 7 ‘S is not recommended for use in pregnant and lactating females. 

Contraindications

Piozer Tablet is contraindicated in the following cases:

• Hypersensitivity to the active agent or excipients. 
• Symptomatic cardiac failure or history of any type of cardiac failure.
• Moderate to severe liver Impairment 
• Diabetic Ketoacidosis (lack of insulin to allow the entry of blood sugar into the cells to use energy)
• Bladder cancer or active renal symptoms (e.g., blood in urine) 
• Active osteoporosis or osteopenia (bone diseases) 

Precautions

Caution should be taken with the use of Piozer 15mg Tablet 7 ‘S in the following cases:

• Piozer Tablet puts a person at risk of congestive heart failure upon the initiation of therapy or after increasing the doses. The patient should be closely observed for the symptoms of heart failure, such as rapid weight gain, edema, shortness of breath, etc. Dose reduction or discontinuation of therapy with Piozer 15mg Tablet 7 ‘S should be considered if these symptoms are visible. 
• As Piozer Tablet its insulin-sensitizing effect only in the presence of insulin, it is not for use in people with type 1 diabetes or diabetic ketoacidosis.
• If you are taking Piozer 15mg Tablet 7 ‘S in combination with other antidiabetic agents, their dose reduction is necessary as administering the combination may put you at risk of hypoglycemia. 
• Piozer Tablet has the potential to decrease the levels of hemoglobin and hematocrit. So routine monitoring of hematocrit helps assess present side effects. 
• People with active liver disease or elevated liver enzymes should not use Piozer 15mg Tablet 7 ‘S as it tends to elevate liver enzymes.
• People who have mild elevation in their liver enzymes should initiate or continue the treatment with Piozer 15mg Tablet 7 ‘S cautiously with routine monitoring and clinical follow-ups. 
• Piozer Tablet has the potential to cause weight gain, but it is dose-related. Dietary changes would help to cope with obesity. 
• Piozer Tablet has the potential to cause blurred vision and macular edema (building up of fluid in the macula of the eye). Routine examination with the ophthalmologist is advised. 
• Females who are on Piozer 15mg Tablet 7 ‘S are more vulnerable to the risk of fractures. 
• Geriatrics are at increased risk of the incidence of bone fracture and heart failure. 

Interactions With Other Medications

Following medications interfere with the metabolism of Piozer 15mg Tablet 7 ‘S and show interaction:

• Rifampicin
• Midazolam
• Baricitinib
• Gemfibrozil
• Ethanol
• Eluxadoline

Your healthcare provider must know if you are on these drugs or have recently consumed them before the initiation of therapy. 

Adverse Effects

Common Side Effects 

• Hypoglycemia (low blood sugar)
• Edema (specifically when used in combination with insulin or sulfonylurea)
• Upper respiratory tract infection
• Weight gain

Less Common Adverse Effects 

• Anemia
• Visual disturbances
• Hematuria
• Headache
• Flatulence
• Dizziness
• Increase in blood creatinine phosphokinase
• Joint and back pain 
• Hypoaesthesia (partial or total loss of sensation in a body part)
• Shortness of breath
• Risk of heart failure

Rare Adverse Effects

• Vertigo 
• Increase in lactic dehydrogenase enzyme
• Enhanced appetite 
• Proteinuria (Excretion of protein in urine)
• Glycosuria (Excretion of glucose in the urine)
• Excessive sweating 

How To Cope with Some of The Adverse Effects

• Hypoglycemia- You can cope with the symptoms of hypoglycemia by taking 15 to 20 g of fast-acting carbohydrates. Fast-acting carbohydrates have sugar content without protein and fat, so they are easily converted into sugar, once inside your body. Stay in a resting position and drink fruit juice, and glucose tablets to help cope with low blood sugar. 
• Weight gain – Weight gain can be controlled by lowering the dose of medicine, eating in little portions, avoiding high calories alcoholic beverages, increasing physical activity such as walking & exercise, and increasing protein intake. Protein will make you feel fuller for a long time. You can also limit weight gain by limiting salt intake i.e., consumption of fewer than 2000 mg of salt per day.
• Anemia – Pale skin, fatigue, weakness, and disturbed appetite are signs of anemia. Eat iron-rich food such as beef, salmon, cereals, liver, dry fruits, and leafy vegetables. Take a good night’s sleep, take rest when needed to avoid fainting, and light exercise daily improves blood flow. 
• Dizziness – Do not get up or change your position immediately when you are feeling dizzy. Instead, get up slowly and steadily. Increase your fluid intake to stay energetic, and refrain from coffee, smoking, alcohol, and addicting drugs. 

Key Facts About Piozer 15mg Tablet 7 ‘S

• Piozer Tablet is an oral antidiabetic agent that works for individuals with type 2 diabetes. 
• Piozer Tablet works by increasing the sensitivity of the liver, skeletal muscle, and adipose tissues to insulin, thereby making insulin effective for the body for glycemic control.
• Piozer Tablet is usually taken once daily irrespective of food. 
• Having a healthy diet, and exercise are the ways to cope with weight gain that a person on Piozer 15mg Tablet 7 ‘S may develop. 
• The mechanism of Piozer 15mg Tablet 7 ‘S’s action is unknown in pregnancy, neither it is known to get secreted in the breast milk. It is therefore not recommended to be used by a pregnant or breastfeeding woman. 

FAQs

Q. HOW DOES Piozer Tablet PRODUCES ITS ANTIDIABETIC EFFECT?

Piozer Tablet is a “glitazone” oral antidiabetic agent that controls high blood sugar by making your body sensitive to insulin. This way, your tissues make use of insulin in lowering blood glucose. 

Q. HOW LONG DOES IT TAKE Piozer Tablet TO PRODUCE ITS EFFECTS?

It takes a few weeks to lower the blood sugar levels. Piozer Tablet helps maintain a stable sugar level and this way, it prevents developing diabetes-associated problems in the future. 

Q. WILL I EXPERIENCE HYPOGLYCEMIA AS A SIDE EFFECT OF Piozer Tablet?

Piozer Tablet if taken alone, does not tend to cause hypoglycemia. However, low blood sugar can occur because of combination therapy. The dose of a combined insulin sensitizer (e.g metformin, Sulphonylureas) is reduced if there is hypoglycemia. 

Q. DOES THE USE OF Piozer Tablet PUT ME AT A RISK OF HEART FAILURE?

Piozer Tablet has the potential to put a person at risk of heart failure but in those who are above 65 years of age. Also, the tendency of this side effect increases if administered with insulin. You should not take Piozer 15mg Tablet 7 ‘S if you had gone through any type of heart failure in the past.  Also, watch yourself for shortness of breath, edema, and swollen legs. These symptoms suspect heart failure. 

Q. CAN Piozer Tablet BE TAKEN BEFORE SURGERY?

Tell your doctor if you are taking Piozer 15mg Tablet 7 ‘S along with other antidiabetic agents or with insulin. Because, if there is hypoglycemia, it will be difficult to distinguish between anesthesia and hypoglycemia after surgery. Your doctor might reduce your insulin dose before surgery. 

Q. DO LIFESTYLE CHANGES AID IN MANAGING DIABETES?

You can maintain your body for glycemic controls by taking a balanced & healthy diet, doing regular exercise, quitting smoking, and refraining from alcohol. Piozer Tablet is usually prescribed along with a suggested diet and exercise when these two factors alone are not enough to control high blood sugar. 

Q. CAN Piozer Tablet MAKE ME FAT?

Use of Piozer 15mg Tablet 7 ‘S is associated with weight gain. A healthy and balanced diet along with regular exercise keeps your body in shape. Piozer Tablet also cause water retention in the body. So, if you feel that your ankles are swollen, and there is shortness of breath, it’s time to visit your doctor. 

Q. IS THERE ANY FOOD I NEED TO AVOID?

Since you need to avoid food with high sugar content, you can check the nutrition labels on the products to see if they suit you. You should avoid fizzy drinks, sweets, chocolates, and cakes. Along with that, you need to keep fast-acting carbohydrates with you such as fruit juices, and sugar cubes for aid if your blood sugar level drops. 

Q. CAN I GO ON A RIDE AFTER TAKING Piozer Tablet?

It depends on the glycemic control of your body. You can drive a vehicle and lift heavy machinery if your blood sugar levels are stable with the use of Piozer 15mg Tablet 7 ‘S. But if you are taking other antidiabetic medications, this puts you at risk of getting hypoglycemic episodes. Monitor your blood glucose frequently and then decide to go on a ride. 

Q. CAN A PREGNANT OR NURSING MOTHER TAKE Piozer Tablet?

The mode of action of Piozer 15mg Tablet 7 ‘S is not known in a childbearing woman, nor the active component is known to be secreted in the human milk. Therefore, its use is not recommended in pregnant or lactating women. 

Q. WHAT ARE THE STORAGE CONDITIONS OF Piozer Tablet?

Store Piozer 15mg Tablet 7 ‘S at room temperature, between 25°C to 30°C and protect it from moisture and direct sunlight.