Corbis H 5mg/6.25mg Tablet 10 ‘S

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Type

Tablet

Feature

5mg/6.25mg

Unit

'S

Formula

Bisoprolol

Composition

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg

Brand

Efroze

Prescription Required

Yes

How to use, Side effects, Uses, Formula & Composition

About

Corbis H 5mg/6.25mg Tablet 10 ‘S is a combination drug that belongs to a class of medicines known as “Antihypertensives”. This drug is prescribed to patients with high blood pressure (normal blood pressure for adults is usually 120/80 mmHg) and to treat patients with mild to moderate chronic heart conditions thus Corbis H 5mg/6.25mg Tablet 10 ‘S is very effective in decreasing the risk of future heart disease. Hypertension if left untreated can cause severe damage to the brain, heart, kidney, blood vessels, and other body organs and may have life-threatening consequences.

Corbis H 5mg/6.25mg Tablet 10 ‘S is chemically composed of 2 chemicals, Bisoprolol (beta-blockers) and Hydrochlorothiazide (Diuretics).  Bisoprolol is a beta-1 selective inhibitor involved in slowing down the heart rate and conduction, as well as stopping kidneys from secreting renin involved in the regulation of blood pressure. Hydrochlorothiazide enhances saltwater excretion in the form of urine, this increased urine output helps control high blood pressure. The dosage of Corbis H 5mg/6.25mg Tablet 10 ‘S is initially set at low potency and gradually increased over a few weeks.

A tablet per day is commonly prescribed to patients to be swallowed with water either with or without a meal. Corbis H 5mg/6.25mg Tablet 10 ‘S is to be taken regularly, preferably at the same time each day a few hours before bedtime to help the patient remember their daily dose. The medicine starts working within 2 hours of taking it. It is important to not stop taking Corbis H 5mg/6.25mg Tablet 10 ‘S abruptly even if the patient is no longer suffering from common symptoms of hypertension as ceasing the intake of the medicine has reported cases of rebound hypertension (the re-emergence of high blood pressure), therefore, physicians taper of the Corbis H 5mg/6.25mg Tablet 10 ‘S’s dosage before completely stopping it. The most common side effects observed with Corbis H 5mg/6.25mg Tablet 10 ‘S include fatigue, dizziness, and skin rash.

Indications

Corbis H 5mg/6.25mg Tablet 10 ‘S is prescribed for the management of:

  • Hypertension 

How Does Corbis H 5mg/6.25mg Tablet 10 ‘S Work?

Corbis H 5mg/6.25mg Tablet 10 ‘S is a combination type of medicine chemically composed of two key chemicals inducing their individual effects to help bring down high blood pressure. Firstly, Bisoprolol being a beta-blocker (Beta-1 selective) influences receptors located on heart cells and kidneys. These control the pumping action of heart muscles, called contractions, slow down its rate as well as the amount of oxygen being consumed during the process. Its second action comes through the kidney which stops the release of renin from its vessels, an enzyme directly involved in the regulation of blood pressure.

Secondly, Hydrochlorothiazide also plays a vital role through its actions exerted via the kidneys to decrease the rising pressure in blood vessels. Salt (sodium chloride) helps the body to retain water in the body which if taken in excess builds pressure in our vessels resulting in high blood pressure. These diuretics aid in getting rid of sodium chloride that is filtered through without absorption into the blood excreted out in urine and releasing extra pressure in vessels.

How to use Corbis H 5mg/6.25mg Tablet 10 ‘S?

Corbis H 5mg/6.25mg Tablet 10 ‘S is available in the form of oral tablets to be swallowed with a glass of water through the mouth with or without a meal, once daily. The dosage at the beginning is set at the lowest effective potency which may be gradually increased to maximum safe dose as per need after 2 weeks. It is advised to ingest Corbis H 5mg/6.25mg Tablet 10 ‘S a few hours before going to sleep at night as this medicine may cause increased urination and might disturb your sleep. Corbis H 5mg/6.25mg Tablet 10 ‘S is not prescribed to children, pregnant or lactating mothers nor to women who are planning to start a family. Adequacy of kidney function must be ensured to avoid complications. The medicine starts working within 2 hours of taking it.

It is advised to not stop treatment abruptly without consulting a doctor as the risk of heart failure and stroke is significantly increased without the drug. Discontinuation of treatment proceeds slowly over 2 weeks.  It is normal to experience the changes of the drug on your body after a minimum of 2 – 4 weeks in cases of treatment for high blood pressure. For heart disease, the changes in the body and blood pressure brought about by Corbis H 5mg/6.25mg Tablet 10 ‘S may take weeks or maybe months to experience. During the treatment, the doctor may alter the dosage (either increase or decrease) after 2 weeks depending on the patient’s response to treatment and any adverse effects felt by the patient.

It is advised that the drug is taken at the same time each day, an alarm can be placed to remind patients to take Corbis H 5mg/6.25mg Tablet 10 ‘S at the proper time each day. If the patient misses a dose of Corbis H 5mg/6.25mg Tablet 10 ‘S, they should take it immediately but if the time for the next dose of the drug is near then it’s beneficial for patients to skip the missed dose and take the tablets as per schedule, doubling of doses has proven to cause severe side effects.

Available Potency and forms of Corbis H 5mg/6.25mg Tablet 10 ‘S 

Tablet – 2.5 mg/ 6.25 mg

Dosage

Adult Dosage

One tablet of Corbis H 5mg/6.25mg Tablet 10 ‘S is prescribed to be taken orally once every night a few hours before bedtime.

At the beginning of the treatment, a low dose is prescribed. The dose of Corbis H 5mg/6.25mg Tablet 10 ‘S may be altered after two weeks depending upon the patient’s response to the drug.

Maximum Suggested dose: 20/12.5 mg once a day, orally

Child Dosage

For patients under the age of 18 years, Corbis H 5mg/6.25mg Tablet 10 ‘S is not considered safe and is therefore not prescribed.

Elderly Dosage

For patients aged 65 years and above, due to decreased kidney function, Corbis H 5mg/6.25mg Tablet 10 ‘S may not be effectively removed from the body and so, in such cases the doctor may prescribe an altered dose of the Corbis H 5mg/6.25mg Tablet 10 ‘S which must be strictly followed.

Pregnancy use and lactation

Corbis H 5mg/6.25mg Tablet 10 ‘S falls under FDA pregnancy category C which means it should not be taken during pregnancy due to potentially harmful effects on unborn babies. Therefore, if you are pregnant, or are planning to conceive a baby, please do discuss Corbis H 5mg/6.25mg Tablet 10 ‘S with your doctor before using it.

If you are breastfeeding an infant, ask your doctor first for the amount of medicine secreted into breast milk is unclear. With regards to safety please make sure to consult your doctor first before using it. 

Contraindications

Please inform your doctor if you have a history of any before using Corbis H 5mg/6.25mg Tablet 10 ‘S:

  • Allergy to Corbis H 5mg/6.25mg Tablet 10 ‘S or sulfonamide derivatives 
  • Severe bradycardia (slow heart rate)
  • Sick sinus syndrome (a group of disorders characterized by abnormal heart rhythms)
  • Uncontrolled heart failure
  • 2nd or 3rd degree AV (heart) block 
  • Severe asthma or COPD (obstructive lung disease)
  • History of bronchospasm (narrowing of airways)
  • Hepatic (liver) impairment
  • Anuria (absence of urination)
  • Severe dehydration 

Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Corbis H 5mg/6.25mg Tablet 10 ‘S:‌ 

  • If there is a history of allergy to medicines or products that are sulfonamide derivatives. Carefully read the contents of this product to avoid any future inconvenience 
  • In certain heart conditions like peripheral heart disease, ‌Corbis H 5mg/6.25mg Tablet 10 ‘S can cause increased severity of symptoms. Caution should be practiced
  • If a patient scheduled for major surgery has been taking Corbis H 5mg/6.25mg Tablet 10 ‘S for a long time, this drug should not be stopped abruptly. Discuss with your doctor since there may be a greater risk involved when using general anesthesia or during surgery
  • Diabetic patients taking antidiabetic drugs should be advised caution and monitored closely because Corbis H 5mg/6.25mg Tablet 10 ‘S is known to conceal symptoms of low blood sugar particularly Tachycardia. Monitor your sugar levels regularly
  • In case you have a thyroid condition, Corbis H 5mg/6.25mg Tablet 10 ‘S can hide the symptoms of hyperactive thyroid like tachycardia. 
  • Adequacy of liver and kidney functions must be ensured
  • In some patients photosensitivity can occur, make sure to cover your skin with protective clothing, use a shade and wear sunblock if stepping outside
  • visual disturbance, pain in the eyes may affect you because of developing acute angle glaucoma, due to diuretic contained in the Corbis H 5mg/6.25mg Tablet 10 ‘S 
  • Patients with chronic lung conditions like asthma, bronchitis, COPD, etc. must use Corbis H 5mg/6.25mg Tablet 10 ‘S with extreme caution 
  • Alcohol intake must be restricted with Corbis H 5mg/6.25mg Tablet 10 ‘S 
  • With Corbis H 5mg/6.25mg Tablet 10 ‘S watch out for equilibrium in your bodily electrolytes. There is a chance of developing hypokalemia or hyponatremia due to the process of diuresis
  • Increased urination can result in dehydration. An adequate amount of fluids should be taken to avoid this 
  • Corbis H 5mg/6.25mg Tablet 10 ‘S must not be stopped abruptly, there should be a gradual reduction in dose over 2 weeks to allow your body to adjust properly
  • Painkillers containing sodium like naproxen or others containing salt must be discussed with the doctor first since they can cause increased blood pressure

Interaction with other medications

Certain medications could interact with Corbis H 5mg/6.25mg Tablet 10 ‘S and may increase or decrease its absorption. Make sure to inform your doctor about all the drugs you’re currently taking, in which case, your doctor might alter the treatment. 

  • Other antihypertensives like reserpine, guanethidine
  • Alpha-blockers like prazosin
  • Calcium channel blockers like verapamil 
  • Antiarrhythmics like disopyramide
  • Clonidine 
  • Digitalis 
  • Diazoxide 
  • Lithium 
  • Probenecid 
  • Rifampicin 

Adverse effects

Like most medicines, Corbis H 5mg/6.25mg Tablet 10 ‘S has some side effects which include:

Common Side Effects

  • Constipation or Diarrhea
  • Headache 
  • Abdominal pain
  • Edema of hands, ankles, and feet
  • Skin rash 
  • Polyuria

Less Common Side Effects

  • Anaphylactic reaction
  • Breathing difficulty 
  • Chest pain
  • Arrhythmia
  • Hypotension
  • hypoglycemia 
  • Tinnitus 
  • Weight gain
  • Somnolence 
  • Loss of libido
  • Muscle cramps 
  • Insomnia 
  • Electrolyte imbalance 
  • Dehydration 
  • Palpitations 
  • Visual disturbance 
  • Pain in eyes 
  • Impotence 

List Of How to Deal With Adverse Effects

  • Allergic Reactions – Allergic reactions to the drug may be mild to severe or potentially could be life-threatening. If allergy is suspected immediately take anti-allergy (antihistamine) medicine which will stop the mild reaction. If a serious allergic reaction is suspected, rush to the nearby hospital and avoid Corbis H 5mg/6.25mg Tablet 10 ‘S and drugs with similar compounds in the future.
  • Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
  • Constipation – Can be combated by adding more fibers to the patient’s diet, asking the patient to drink plenty of fluids, and increasing their physical activity to trigger contractions in the intestines.
  • Feeling or being sick (nausea or vomiting) or diarrhea – Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water. 
  • Feeling dizzy (lightheaded) or weak – If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.
  • Blurred vision – This side effect tends to go away on its own if a few days; patients are advised to not operate heavy machinery or drive any motorized vehicles in the meantime. If blurred vision persists, please contact your doctor.
  • Dehydration- Patients are recommended to always care around a water bottle with them wherever they go and periodically keep sipping to prevent thirst and extremely dry mouth. Ice pops in hot weather and energy drinks (verified by the doctor) help combat dehydration.

FAQs

#1. CAN LIFESTYLE CHANGES HELP ME WITH MY CONDITION?

Yes, you can adopt certain healthy lifestyle changes to help with high blood pressure. These include quitting smoking, avoiding alcohol, eating a wholesome diet consisting of fresh vegetables and fruits with the cut down on salt, and incorporating physical activity into your daily routine.

#2. WHAT IF I TAKE TOO MUCH OF Corbis H 5mg/6.25mg Tablet 10 ‘S?

In case of too much consumption by accident, kindly contact your doctor or nearby hospital straight away. The amount of medication that can result in severe side effects varies from person to person. An overdose results in slowing down of heart rate and difficulty breathing accompanied by dizziness and fainting spells.

#3. IS IT SAFE TO HAVE Corbis H 5mg/6.25mg Tablet 10 ‘S BEFORE UNDERGOING ANY SURGICAL PROCEDURE?

If the surgical procedure involves general anesthesia, the surgeon may ask you to stop the intake of the drug for 24 to 48 hours as general anesthesia also tends to lower blood pressure levels in a few patients. Stopping the medicine abruptly is not advised, therefore seek the doctor’s advice.

#4.HOW IS Corbis H 5mg/6.25mg Tablet 10 ‘S SUPPOSED TO BE TAKEN?

Corbis H 5mg/6.25mg Tablet 10 ‘S is to be ingested orally once daily or as per a doctor’s prescription. Corbis H 5mg/6.25mg Tablet 10 ‘S is to be swallowed either with or without food, preferably with water to ease the tablet’s passage to the patient’s throat. As per suggestions, it is taken a few hours before bedtime.

#5. CAN I TAKE Corbis H 5mg/6.25mg Tablet 10 ‘S DURING MY PREGNANCY?

This drug is not to be taken or prescribed to expecting and lactating mothers as it may have severe consequences for the unborn child. If you are taking the drug and become pregnant, inform your doctor immediately. Corbis H 5mg/6.25mg Tablet 10 ‘S isn’t recommended to lactating mothers. If you are planning to conceive and are taking Corbis H 5mg/6.25mg Tablet 10 ‘S as treatment, then refer to the doctor. The physician is likely to change your medicine and dosage.

#6.HOW TO STORE Corbis H 5mg/6.25mg Tablet 10 ‘S?

Corbis H 5mg/6.25mg Tablet 10 ‘S is to be kept away from the reach of children, in a cool dry place away from direct sunlight and humidity as that tends to ruin certain drugs.

#7. DOES Corbis H 5mg/6.25mg Tablet 10 ‘S CAUSE ADDICTION?

No, this drug has shown no evidence to prove addiction of any kind in any patient.

#8. WHAT LAB TESTS WILL BE PRESCRIBED WHILE TREATMENT WITH Corbis H 5mg/6.25mg Tablet 10 ‘S AND HOW OFTEN?

Kidney and liver function tests along with blood tests to keep a check on serum potassium, sodium, and calcium levels are advised to be done periodically. The patient’s blood sugar levels are also to be monitored regularly. It is also advised that patients learn to monitor their blood pressure levels daily at home and inform their doctor of any changes seen.

#9. CAN I CONSUME ALCOHOL WITH Corbis H 5mg/6.25mg Tablet 10 ‘S?

Alcohol is also known to lower your blood pressure which if taken with the medication may lead to extreme dizziness. It is best to avoid the intake of alcohol during your treatment.

#10. WHAT IF I FORGET TO TAKE THE Corbis H 5mg/6.25mg Tablet 10 ‘S?

It is advised that the drug is taken at the same time each day, an alarm can be placed to remind patients to take Corbis H 5mg/6.25mg Tablet 10 ‘S at the proper time. If the patient misses a dose of Corbis H 5mg/6.25mg Tablet 10 ‘S, they should take it immediately but if the time for the next dose of the drug is near then it’s beneficial for patients to skip the missed dose and take the tablets as per schedule, doubling of doses has proven to cause severe side effects.

#11. IS Corbis H 5mg/6.25mg Tablet 10 ‘S SAFE TO GIVE TO ELDERLY PATIENTS?

Yes, For elderly patients the dosage of the drug may be lower than normal due to decreased kidney function, Corbis H 5mg/6.25mg Tablet 10 ‘S may not be effectively removed from the body and so, in such cases the doctor may prescribe an altered dose of the Corbis H 5mg/6.25mg Tablet 10 ‘S.

#12. CAN Corbis H 5mg/6.25mg Tablet 10 ‘S INTERFERE WITH FERTILITY?

There is no evidence to support the above statement. If a patient does become pregnant it is imperative that they inform their doctor immediately as Corbis H 5mg/6.25mg Tablet 10 ‘S can have fatal effects on the developing fetus.

#13. WILL Corbis H 5mg/6.25mg Tablet 10 ‘S AFFECT MY SEXUAL ACTIVITY?

Although it is not a common side effect, some patients have experienced a decrease in sexual drive or erection problems. If this affects you, discuss it with your doctor. 

#14 CAN I DRIVE AFTER TAKING THIS MEDICATION?

This medication is known to make you dizzy hence if that happens kindly avoid driving or operating any heavy machinery.

#15. CAN Corbis H 5mg/6.25mg Tablet 10 ‘S CAUSE DIZZINESS? IF SO, HOW SHOULD I MANAGE IT?

Yes. It can cause dizziness as one of the most common side effects. If this happens, you should sit or lie down until the symptoms pass. However, please note this is temporary and usually goes away as the treatment continues. It is also advised to avoid the consumption of alcohol during your treatment, as it may worsen the dizziness.