Tydel 75mg Tablet 10 ‘S

Description

About

Analgesics are commonly prescribed to treat one’s pain, the most used group is NSAIDs. But in conditions where the pain is unmanageable with regular painkillers, a potent form may be required. One such category of analgesics is called Opioids, which are relatively stronger and affects the central nervous system. Tydel 75mg Tablet 10 ‘S also belongs to this class of non-NSAID analgesics, used to manage moderate to severe acute or neuropathic pain that does not resolve with NSAIDs. Although when compared with morphine it is relatively mild in action. 

Tydel 75mg Tablet 10 ‘S works by showing a binary effect on Mu receptors (MOR) present in the brain by enhancing its activity, as well as inhibiting noradrenaline reuptake by the cell which increases their level outside the cells. This double action leads to blockage of pain sensation. Tydel 75mg Tablet 10 ‘S in its immediate release formulations, starts working in approximately 30 minutes. Since it is an opioid, there is an element of abuse associated with this drug, hence extreme caution is advised and must not be stopped suddenly. 

Tydel 75mg Tablet 10 ‘S is available in form of tablets to be taken orally, usually 3 to 4 times a day if it is immediate release or just once or twice if delayed release formula is being taken, regardless of the meals. While Tydel 75mg Tablet 10 ‘S can be prescribed to adults, it is not prescribed to children and adolescents below 18 years, also pregnant and lactating mothers should abstain from taking it due to a risk to the unborn babies. The most common side effects observed with Tydel 75mg Tablet 10 ‘S include anxiety, confusion, appetite loss, mood changes, and withdrawal. 

Indications

Tydel 75mg Tablet 10 ‘S is prescribed to adults 18 years and above and it is used for the management of pain:

  • Moderate to severe acute pain
  • Neuropathic pain 

  • Pain associated with chronic conditions

How Does Tydel 75mg Tablet 10 ‘S Work

Tydel 75mg Tablet 10 ‘S is one of those composite drugs whose working mechanism has a  binary effect. It works on both, Mu receptors (MOR) present in the brain by enhancing its activity, as well as inhibiting noradrenaline reuptake by the cell which increases their level outside the cells. The combined action helps control the pain of both acute and chronic nature. 

How to use Tydel 75mg Tablet 10 ‘S

Tydel 75mg Tablet 10 ‘S is available in form of oral tablets to be taken with a glass of water at 4 to 8  hourly intervals if immediate release medicine is being taken. In the case of delayed-release tablets, a once or twice daily dose is suggested. It depends on your pain intensity, release formula, and other health conditions. Dosage recommendations by the doctor must be strictly followed to avoid taking excess. Tydel 75mg Tablet 10 ‘S being an opioid, has a centrally acting nature for which reason it should be used cautiously. 

With opioid drugs, dose adjustment is the key. Treatment is started on the lowest dose showing the clinical effects, which can be increased gradually in 50 mg increments every 3 to 4 days with strict monitoring.  Withdrawing the drug spontaneously without a doctor’s advice is not recommended since it can cause withdrawal symptoms. When Tydel 75mg Tablet 10 ‘S needs to be stopped, it is done so in a gradual contraction process by 20% from the total dose every 3  to 4 days 

Immediate-release (IR): These medicines are, labeled as “IR”- the name suggests that they start releasing chemicals in the body without any delay, once consumed. This means more frequent doses spaced at regular intervals can be given since medicine will stay for shorter periods in the body.

Extended-release (ER): These medicines are, labeled as “ER”- the name suggests that they release chemicals in the body slowly over hours. This means once or often twice a day tablets can be given since medicine will stay in the body for longer durations.

Dosage

Adult Dose

Make sure to take the correct potency and formulation.

Acute Pain (moderate to severe)

Immediate release: 50 to 100 mg to be taken orally at 4 to 6 hours intervals or as per need

Maximum safe dose: 700 mg per day (day 1), 600 mg per day (day 2 and onwardExtended-release

Extended release: 50 to 250 mg to be taken orally at 12 hours intervals as per need

Patients without chronic opioid intake history: Start with 50 mg to be taken orally 12 hourlies 

Maximum safe dose: 500 mg per day

Chronic Severe Pain

50 to 250 mg to be taken orally at 12 hours intervals 

Patients without chronic opioid intake history: Start with 50 mg to be taken orally 12 hourlies 

Maximum safe dose: 500 mg per day

Diabetic Peripheral Neuropathy

Starting dose 50 mg to be taken orally 12 hourly which can be slowly increased in increments as tolerance develops, to a higher range of  100 to 250 mg every 12 hours

Pediatric Dose

Tydel 75mg Tablet 10 ‘S is not safe to use in children or adolescents below 18 years of age.

Elderly dose

Tydel 75mg Tablet 10 ‘S must be used with caution in patients aged 60 and above. The dose is kept at a minimally effective range, follow your prescription.

*Special Dose: adjustment required in moderate liver impairment

Do not take medicine if there is severe liver inadequacy

Pregnancy use and lactation

Tydel 75mg Tablet 10 ‘S is FDA pregnancy risk category C (may be harmful to the fetus causing anomalies), therefore if you are pregnant, think you may be pregnant, or are planning to have a baby, please consult your doctor. Also Tydel 75mg Tablet 10 ‘S is secreted into human milk, if you are breastfeeding Tydel 75mg Tablet 10 ‘S is not recommended, please consult your doctor before taking it.

Contraindications

Please inform your doctor if you have a history of any before using Tydel 75mg Tablet 10 ‘S:

  • Allergic reaction to Tydel 75mg Tablet 10 ‘S or other opioids
  • Allergy to Tydel 75mg Tablet 10 ‘S or any other medicine or food substance 

  • Acute intoxication with alcohol

  • Addiction to hypnotics, analgesics, or other CNS-acting drugs

  • Severe respiratory depression or lung conditions like asthma 

  • Renal (kidney) impairment

  • Severe liver impairment

  • Uncontrolled seizures

  • History of use of antidepressants like MAO inhibitors (selegiline, etc) in the last 14 days

  • Obstructed bowels such as paralytic ileus

  • Recent head injury

  • Brain hemorrhage 

Precautions‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Tydel 75mg Tablet 10 ‘S:‌ 

  • Tydel 75mg Tablet 10 ‘S must be given to elderly patients with caution especially those with health conditions. Doses are kept low

  • There is an element of abuse associated with this drug, hence extreme caution is advised and must not be stopped suddenly. 

  • Severe breathing difficulties are particularly a challenge when using Tydel 75mg Tablet 10 ‘S, especially at the start of the treatment. Monitoring is advised to avoid fatalities 

  • Tydel 75mg Tablet 10 ‘S should not be used in pregnancy for it may harm the unborn baby

  • Difficulties in breathing while asleep, called sleep apnea can affect you while using Tydel 75mg Tablet 10 ‘S. Discuss with your doctor 

  • A recent incident of head injury should be mentioned before taking Tydel 75mg Tablet 10 ‘S

  • Patients with a history of drug addiction must not use Tydel 75mg Tablet 10 ‘S

  • Alcohol intake should be avoided with this medicine

  • Caution is advised in patients with renal disease and reduced liver function

  • Tydel 75mg Tablet 10 ‘S can alter blood pressure, thereby regular monitoring of blood pressure is advised

  • Tydel 75mg Tablet 10 ‘S if stopped abruptly, causes withdrawal symptoms. A more gradual reduction in dose is advised

  •  Do not share Tydel 75mg Tablet 10 ‘S with anyone 

  • This medicine is known to cause extreme drowsiness, so avoid all activities requiring mental and physical strength

Interaction with other medications

Certain medications could interact with Tydel 75mg Tablet 10 ‘S and may increase or decrease its absorption, in which case, your doctor might alter your dosage. A few of these interacting drugs are given below:

  • MAO inhibitors (concomitant or in last 2 weeks) like selegiline, rasagiline
  • Mu receptor antagonists like alvimopan

  • Selective serotonin reuptake inhibitors (SSRIs) like citalopram

  • Serotonin and norepinephrine reuptake inhibitors (SNRIs) like desvenlafaxine

  • Tricyclic antidepressants (TCAs) like Amitriptyline.

  • Cimetidine 

  • Alpha agonists like clonidine 

  • Opioids like fentanyl, tramadol, fentanyl, etc. 

  • Butorphanol 

  • Calcium/potassium/sodium or similar salt oxybates

Adverse Effects

Common Adverse Effects

Like most medicines,Tydel 75mg Tablet 10 ‘S has certain side effects which include:

  • Nausea 
  • Sweating

  • Dizziness

  • Hallucinations 

  • Vomiting

  • Dry mouth

  • Fatigue

  • Somnolence (sleepiness)

  • Headache

Less Common Adverse Effects

  • Hypersensitivity reaction
  • Trembling (fits)

  • Confusion

  • Mood changes

  • Anxiety

  • Nervousness

  • Euphoria (state of intense excitement)

  • Sleep disorders

  • Pruritus (itchy skin)

  • Respiratory failure 

  • Drug addiction 

  • Changes in heart rate 

  • Changes in blood pressure 

  • Problems in urination 

  • Convulsions 

LIST OF HOW TO DEAL WITH ADVERSE EFFECTS

  • Feeling drowsy – If the medication makes you feel drowsy or sleepy, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

  • Headaches- In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe

  • Feeling or being sick (nausea or vomiting) or diarrhea –Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water.

  • Feeling dizzy (lightheaded) or weak –If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

  • Constipation- Can be combated by adding more fibers to the patient’s diet, asking the patient to drink plenty of fluids, and increasing their physical activity to trigger contractions in the intestines.

  • Skin Rash- can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. An antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash

  • Blurred vision-  This side effect tends to go away on its own if a few days; patients are advised to not operate heavy machinery or drive any motorized vehicles in the meantime. If blurred vision persists, please contact your doctor.

FAQs

# 1. WHAT IF I TAKE TOO MUCH OF Tydel 75mg Tablet 10 ‘S?

In case of too much consumption by accident, kindly contact your doctor or nearby hospital straight away. The amount of medication that can result in severe side effects varies from person to person. An overdose results in a slowing down of heart rate and difficulty breathing accompanied by dizziness and fainting spells.

#2. HOW IS Tydel 75mg Tablet 10 ‘S SUPPOSED TO BE TAKEN?

{{product} is to be taken orally, as per the doctor’s prescription. Tydel 75mg Tablet 10 ‘S is to be taken either with or without food, with a glass of water. 

#3. HOW DOES Tydel 75mg Tablet 10 ‘S WORK?

Tydel 75mg Tablet 10 ‘S successfully combines two pain relief mechanisms. One of them is mu receptor agonist action and another is noradrenaline reuptake inhibition, which helps in blocking the pain sensation. 

#4. CAN I TAKE Tydel 75mg Tablet 10 ‘S DURING MY PREGNANCY?

No, Tydel 75mg Tablet 10 ‘S has been known to cause harm to the fetus and cause complications during pregnancy. Hence, it is advised to consult your doctor if you are pregnant or planning to conceive or may think you are pregnant. Small amounts of this drug can be transferred to the child through breast milk and therefore cause low blood pressure in the child,  thus Tydel 75mg Tablet 10 ‘S isn’t recommended to lactating mothers.

#5. HOW TO STORE Tydel 75mg Tablet 10 ‘S?

Tydel 75mg Tablet 10 ‘S is to be kept away from the reach of children, in a cool dry place away from direct sunlight and humidity at room temperature (below 30°C) as that tends to ruin certain drugs.

#6. DOES {product}} CAUSE ADDICTION?

Yes, inappropriate use of Tydel 75mg Tablet 10 ‘S for a long period, may cause addiction to Tydel 75mg Tablet 10 ‘S. 

#7. CAN I CONSUME ALCOHOL WITH {{PRODUCT}}?

Alcohol is known to cause extreme dizziness. It must be avoided during your treatment as Tydel 75mg Tablet 10 ‘S causes dizziness as well.

#8. CAN {{PRODUCT}} INTERFERE WITH FERTILITY?

There isn’t sufficient evidence to suggest that Tydel 75mg Tablet 10 ‘S interferes with fertility; discuss your concerns with a doctor

#9. CAN I DRIVE AFTER TAKING THIS MEDICATION?

This medication is known to make you dizzy hence if that happens kindly avoid driving or operating any heavy machinery.

Additional information

Type

Tablet

Feature

75mg

Unit

'S

Formula

Tapentadol

Composition

Tapentadol 75 mg

Brand

Ccl Pharma

Prescription Required

Yes