Domel 5mg/5ml Suspension 60 ml

Domel 5mg/5ml Suspension 60 ml is prescribed to treat discomfort caused by stomach problems such as nausea and vomiting

Domel 5mg/5ml Suspension 60 ml is also prescribed to ease the after-effects of chemotherapy 

Domel 5mg/5ml Suspension 60 ml contains Domperidone Maleate 

Domel 5mg/5ml Suspension 60 ml is available in liquid format

Domel 5mg/5ml Suspension 60 ml is to be ingested orally (via mouth)

 

Categories: , ,
Type

Suspension – Syrup

Feature

5mg/5ml

Unit

ml

Formula

Domperidone Maleate

Composition

Domperidone Maleate 5 mg / 5 ml

Brand

Barrett Hodgson

Prescription Required

Yes

How to use, Side effects, Uses, Formula & Composition

About

Dopamine is one of the most important neurotransmitters involved in several natural mechanisms. The gastric tract also releases dopamine from the stomach and influences GIT from its upper to the lower part.  Domel 5mg/5ml Suspension 60 ml belongs to a class of drugs called “dopamine receptor antagonists”, commonly referred to as anti-emetics used for the prevention and management of nauseous states. It also helps relieve symptoms of gastroparesis, a health condition that affects the stomach and normal bowel movements resulting in indigestion, nausea, and vomiting. Where it helps ease the symptoms, it also carries a high risk of serious side effects on the heart, for which reason it is disapproved in some countries like the USA, so caution is advised

Domel 5mg/5ml Suspension 60 ml is chemically composed of Domperidone which works by blocking the action of dopamine (D2 and D3 receptors) and enhances the effects of acetylcholine in the gastric tract, the outcome of which is manifested in form of enhanced gastric movement and digestion as well as increased pressure in the lower part of the esophagus that helps prevent reflux of stomach contents. Through its action on the brain, it helps control vomiting too.  Domel 5mg/5ml Suspension 60 ml takes about 30 minutes to 1 hour to start working. 

Domel 5mg/5ml Suspension 60 ml is available in the form of oral suspension on prescription to be swallowed via mouth with a glass of water, a few mL usually 3 times a day or as advised by the doctor.  It works better if you take it at least 30 minutes before your meal. Domel 5mg/5ml Suspension 60 ml can be safely prescribed to adults and children above 12 years of age. In case of pregnancy and lactation, ask your doctor first due to potentially harmful effects on the unborn baby. The most common side effects observed with Domel 5mg/5ml Suspension 60 ml are drowsiness, diarrhea, loss of appetite, dry mouth, etc.

Indications

Domel 5mg/5ml Suspension 60 ml is prescribed to children (above 12 years) and adults to treat:

  • Gastroparesis 
  • Nausea 
  • Vomiting 
  • Heartburn 
  • Dyspepsia 
  • Epigastric pain 
  • Management of nausea/vomiting in patients on palliative care 

How does Domel 5mg/5ml Suspension 60 ml work

Domel 5mg/5ml Suspension 60 ml is chemically composed of Domperidone which works by blocking the action of dopamine (D2 and D3 receptors) and enhances the effects of acetylcholine in the gastric tract, the outcome of which is manifested in form of enhanced gastric movement and digestion as well as increased pressure in the lower part of the food pipe (esophagus) that helps prevent reflux of stomach contents. . Domel 5mg/5ml Suspension 60 ml influences the chemoreceptor trigger zone present in the brain that regulates vomiting.

How to use Domel 5mg/5ml Suspension 60 ml

Domel 5mg/5ml Suspension 60 ml is available in the form of oral suspension. Swallow the prescribed amount with a glass of water 15 to 30 minutes before taking a meal. Domel 5mg/5ml Suspension 60 ml is preferably taken at the same time every day till the prescribed time to maintain equal blood levels at all times. Domel 5mg/5ml Suspension 60 ml is taken orally as per recommended doses. It is usually taken 3 to 4 times a day at 6 to 8 hourly intervals before a meal. Domel 5mg/5ml Suspension 60 ml should be taken at a set time and for the prescribed length of time, not exceeding it. The patient in general starts to feel better in a couple of days, make sure to complete the entire course even if you feel better. Treatment must not last longer than 7 days. 

Domel 5mg/5ml Suspension 60 ml comes packaged in a glass bottle with a calibrated cup (with mL markings) to take out accurate doses. Shake the bottle vigorously to mix the contents well.  Do not use household spoons or utensils for this purpose, alternatively, a syringe can be purchased from a pharmacy for dosing purposes. The oral suspension of Domel 5mg/5ml Suspension 60 ml contains 5 mg of domperidone per 5 ml. See the dosage below.  

Available Potency of Domel 5mg/5ml Suspension 60 ml 

  • 1mg/ 5 ml             –    Suspension
  • 5 mg/ 5 ml            –    Suspension
  • 10 mg/ 5 ml          –    Suspension
  • 100 mg/ 5 ml        –    Suspension      
  • 120 mg/ 5 ml        –    Suspension

Dosage

Adult Dose

10 mL to 20 mL (1mg domperidone per mL of suspension) three to four times per day at 6 to 8 hours intervals or as advised by the doctor with a  before meals 15 to 20 minutes earlier

Maximum Daily safe dose: 80 mL

Pediatric Dose

Not recommended for children under 12 years of age. For children and adolescents above 12 years of age:

10 mL to 20 mL (1mg domperidone per mL of suspension) three to four times per day at 6 to 8 hours intervals or as advised by a doctor with a  before meals 15 to 20 minutes earlier

Maximum Daily safe dose: 80 mL

Elderly Dose

The exact dose must be determined by your doctor, ideally being the lowest effective due to serious heart side effects which may be more pronounced in elderly patients. Especially those taking any other heart medication concurrently. Seek a doctor’s advice.  

Pregnancy Use and Lactation

Domel 5mg/5ml Suspension 60 ml is classified as a pregnancy category B drug by FDA (meaning no evidence of any risk in controlled animal trials but regarding the human fetus, insufficient data is available). It is advised if you are pregnant or are planning to conceive, please consult your doctor before using Domel 5mg/5ml Suspension 60 ml. Domel 5mg/5ml Suspension 60 ml is also secreted in human milk in little amount, if you are breastfeeding, please consult your doctor before taking Domel 5mg/5ml Suspension 60 ml. 

Contraindications

Please inform your doctor if you have a history of any before using Domel 5mg/5ml Suspension 60 ml:

  • Allergic reaction to Domel 5mg/5ml Suspension 60 ml or similar drugs
  • Severe Liver disease 
  • Prolactinoma 
  • History of serious heart disease
  • Heart failure 
  • Prolonged corrected QT interval 
  • Hypo or hyperkalemia 
  • Low blood magnesium 
  • Unexplained Black tarry stool or blood in stool 
  • Bleeding from intestines 
  • Blocked intestines in conditions like diverticulitis, Crohn’s disease
  • Underweight patients (less than 35 kgs)
  • Pregnancy 
  • Patients under 12 years of age

Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Domel 5mg/5ml Suspension 60 ml:‌ ‌

  • Make sure to rule out any allergies to  ‌Domel 5mg/5ml Suspension 60 ml or any similar drug
  • ‌Domel 5mg/5ml Suspension 60 ml works better if taken 15 to 30 minutes before a meal. Taking it after the meal will slow down its function
  • Compromised liver function can negatively affect your body since ‌Domel 5mg/5ml Suspension 60 ml is largely processed in it, discuss it with your doctor. 
  • Ensure adequate kidney function before using  ‌Domel 5mg/5ml Suspension 60 ml
  • Elderly patients (65 years and above) should exercise caution if prescribed  ‌Domel 5mg/5ml Suspension 60 ml, especially if they are feeble and have a history of heart condition or taking doses of more than 30 mg per day
  • Patients suffering from chronic gut disease must be careful, especially those with a history or an existing Gastrointestinal Perforation/ bleeding must avoid it
  • Alcohol consumption may potentiate the side effects, it must be avoided or restricted with ‌Domel 5mg/5ml Suspension 60 ml
  • If you are taking medicines for conditions affecting heart rhythm or other, especially those that  prolong the QTc interval, you should not take ‌Domel 5mg/5ml Suspension 60 ml
  • Treatment with ‌Domel 5mg/5ml Suspension 60 ml usually proceeds with a minimal dose able to give clinical benefits, caution is advised if the dose exceeds more than 30 mg per day in adults/ adolescents or children 
  • If you are pregnant or lactating mother, consult a doctor first to determine if ‌Domel 5mg/5ml Suspension 60 ml is safe for you.
  • ‌Domel 5mg/5ml Suspension 60 ml is known to cause increased levels of the hormone prolactin in the body. Rule out the presence of any tumor (such as prolactinoma or pituitary gland tumor)

Interaction With Other Medications

Following drugs can have some interactions with Domel 5mg/5ml Suspension 60 ml and can potentiate or reduce the effects when used concomitantly. Some of these drugs are:

  • Azole antifungals ketoconazole, fluconazole
  • Calcium channel blockers like verapamil, diltiazem 
  • Macrolide antibiotics like erythromycin, clarithromycin 
  • Antiarrhythmic drugs like quinidine, disopyramide
  • Antidepressants like citalopram, escitalopram
  • Antipsychosis or schizophrenia such as haloperidol, pimozide 
  • Gastric drugs cisapride, dolasetron
  • Antimalarial 
  • Anti- HIV drugs 
  • Chemotherapeutic agents like toremifene
  • Anti histamines like mequitazine

Adverse effects

Like most medicines, Domel 5mg/5ml Suspension 60 ml has some side effects which include:

Common Side effects:

  • Constipation /Diarrhea  
  • Headache 
  • Dry mouth 
  • Skin rash
  • Abdominal cramps 

Rare side effects:

  • Anaphylactic reaction 
  • Blurred vision
  • Fatigue 
  • Restlessness/ agitation 
  • Loss of appetite 
  • Nervousness 
  • Anxiety 
  • Uncontrolled eye movement 
  • Inability to urinate (urinary retention)
  • Breast tenderness 
  • Gynecomastia 
  • Milk secretion from breasts 
  • Arrhythmias 
  • Disturbance in the menstrual cycle 
  • Low sex drive 
  • Changes in LFTs

 HOW TO COPE-UP WITH ADVERSE EFFECTS

Dry Mouth – Can be helped by sipping water throughout the day, chewing sugarless gum, using alcohol-free mouthwash, allowing ice to melt in the mouth, or using a saliva substitute.

Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe

Skin Rash – Can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. Antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.to bring ease as well. Avoid high-intensity exercise while suffering from muscular pain.

Constipation – Can be combated by adding more fibers to the patient’s diet, asking the patient to drink plenty of fluids, and increasing their physical activity to trigger contractions in the intestines.

Dehydration- Patients are recommended to always care around a water bottle with them wherever they go and periodically keep sipping to prevent thirst and extremely dry mouth. Ice pops in hot weather and energy drinks (verified by the doctor) help combat dehydration.

FAQ’S

#1. WHAT EXACTLY DOES Domel 5mg/5ml Suspension 60 ml DO?

Domel 5mg/5ml Suspension 60 ml helps relieve symptoms of nausea, vomiting, and sickness. It works by blocking the effects of specific dopamine neurotransmitters (D2, D3)resulting in enhanced gastric movement and digestion and also helps prevent gastric reflux.

#2. HOW LONG WILL I HAVE TO TAKE Domel 5mg/5ml Suspension 60 ml FOR?

 Domel 5mg/5ml Suspension 60 ml is usually taken for short treatment not exceeding 1 week and not a long-term course

#3. HOW LONG DOES IT TAKE FOR Domel 5mg/5ml Suspension 60 ml TO START WORKING?

The onset of action normally starts working within 30 minutes to 1 hour of ingestion

#4. CAN I STOP TAKING Domel 5mg/5ml Suspension 60 ml?

Consult your doctor for the exact time you are supposed to take Domel 5mg/5ml Suspension 60 ml and stop it after professional advice 

#5. WHAT IF I TAKE TOO MUCH OF Domel 5mg/5ml Suspension 60 ml?

If you have taken too much of the prescribed Domel 5mg/5ml Suspension 60 ml you may experience symptoms of overdose, for example, fast pounding, irregular heartbeat, upset stomach, blurred vision, fainting, dizziness, seizures, or life-threatening severe symptoms. Contact your doctor immediately and rush to a nearby hospital if you have any of these symptoms. toxicity can be fatal if left unattended.

#6. WHAT IF I FORGET TO TAKE Domel 5mg/5ml Suspension 60 ml?

Domel 5mg/5ml Suspension 60 ml is taken 3 to 4 times a day before meals so you can take the missed dose as soon as you remember unless it’s less than 8 hours until your next dose, in which case you should skip the missed dose. If it helps to remind you, set an alarm or use a pill organizer or a mobile application so you do not miss any dose. Make sure to complete your course of treatment even if you feel better and think you do not need to take it anymore.

#7. CAN I TAKE Domel 5mg/5ml Suspension 60 ml DURING PREGNANCY OR BREASTFEEDING?

Domel 5mg/5ml Suspension 60 ml may have a safety concern for the unborn baby, hence not advised without a doctor’s consultation. If you are pregnant, think you may be pregnant, or are planning to conceive a baby, please consult your doctor before using Domel 5mg/5ml Suspension 60 ml. If you are breastfeeding, please consult your doctor before taking Domel 5mg/5ml Suspension 60 ml. 

#8. HOW SHOULD Domel 5mg/5ml Suspension 60 ml BE STORED?

Store it at room temperature, away from excess heat, direct sunlight, and moisture. Make sure it is not consumed by pets, children, and other people. Dispose of the unused medicine. 

#9. CAN I DRIVE OR RIDE A BIKE AFTER TAKING Domel 5mg/5ml Suspension 60 ml?

Usually Domel 5mg/5ml Suspension 60 ml  is not known to cause dizziness but make sure you know how your body reacts while using Domel 5mg/5ml Suspension 60 ml’. Do not drive or use any machinery until you feel normal again.

#10. WILL Domel 5mg/5ml Suspension 60 ml AFFECT MY FERTILITY? 

Although not very common but Domel 5mg/5ml Suspension 60 ml can create disturbance in the menstrual cycle which is reversible. High prolactin levels can cause problems in ovulation in women. Discuss it with your doctor.