Protonix 40mg Injection 1 vial

Description

About

Protonix 40mg Injection 1 vial belongs to a group of drugs known as proton pump inhibitors. Protonix 40mg Injection 1 vial is prescribed to treat the symptoms of Erosive Esophagitis associated with GERD (a syndrome in which the stomach’s acid flows backward, causing heartburn and possibly esophageal damage), GERD short-term therapy, and Zollinger-Ellison Syndrome (increased production of stomach acid due to malignancies in the pancreas and small intestine).

Protonix 40mg Injection 1 vial is prescribed to adults and children at least 5 years old. Protonix 40mg Injection 1 vial can be taken on its own or in combination with other drugs. 

Protonix 40mg Injection 1 vial works by lowering the amount of acid produced by the stomach. It treats symptoms like heartburn, difficulties swallowing food, stomach pain, and vomiting by reducing excess acid production in the stomach. 

Protonix 40mg Injection 1 vial is administered by trained medical professionals, as Protonix 40mg Injection 1 vial is found in solution form to be administered intramuscularly or intravenously. It is usually given once a day for 7-10 days for the treatment of GERD and is given every 8-12hrs in conditions involving excess acid production. Protonix 40mg Injection 1 vial is recommended only when oral administration of Pantoprazole is not recommended. 

If you have any significant side effects, such as symptoms of a low magnesium blood level (such as extremely fast/slow/irregular heartbeat, chronic muscle spasms, seizures), or evidence of lupus (such as rash on nose and cheeks, new or worsening joint pain), contact your doctor immediately. 

Indications

Protonix 40mg Injection 1 vial is a prescription medicine used to treat the symptoms of:

• Erosive esophagitis (esophageal damage caused by stomach acid associated with Gastroesophageal reflux disease-GERD)
• Zollinger-Ellison syndrome
• Gastric and duodenal ulcers
• Other pathological hypersecretory conditions 

How Does Protonix 40mg Injection 1 vial Work

Protonix 40mg Injection 1 vial contains Pantoprazole as an active ingredient. Protonix 40mg Injection 1 vial is a proton pump inhibitor (PPI) that covalently binds to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell, suppressing the final step in stomach acid generation. Regardless of the stimulus, this action inhibits both basal and induced stomach acid output. For all doses studied, binding to the (H+, K+)-ATPase results in an antisecretory action that lasts longer than 24 hours (20 mg to 120 mg). 

How To Use Protonix 40mg Injection 1 vial

A qualified healthcare practitioner injects Protonix 40mg Injection 1 vial into the patient’s muscles (intramuscular route) or in the patient’s vein (intravenously). An alcohol swab or any other disinfectant available at the hospital is used to disinfect the area where the needle will pierce the skin. The needle is then unscrewed, and the solution is injected slowly into the body. Protonix 40mg Injection 1 vial is infused intravenously nonstop for a period of time usually given once a day for 7-10 days for the treatment of GERD and is given every 8-12hrs in conditions involving excess acid production. 

A ready-to-use solution is prepared, within 12 hours of obtaining the solution, Protonix 40mg Injection 1 vial must be administered. 

Protonix 40mg Injection 1 vial should be given intravenously over for 2 to 15 minutes. 

The area of skin where the needle is inserted may bruise or be uncomfortable for up to 24 hours. The needle puncture is pressed down (by hand) for 20 seconds after the injection to ensure there is no bleeding, and then a band-aid is placed on top. It is not recommended that you use Protonix 40mg Injection 1 vial with any other medications. Protonix 40mg Injection 1 vial is usually given for up to 7days and up to 8 weeks at a time until your esophagus heals.

Dosage

Form and strength

Intravenous Infusion: 40mg

Adult Dosage 

Gastric and duodenal ulcers, and reflux esophagitis: the recommended adult dosage of Protonix 40mg Injection 1 vial is one vial per day for 7-10days

Zollinger-Ellison syndrome and other pathological hypersecretory conditions: Protonix 40mg Injection 1 vial can be given every 8-12hrs or as recommended by your doctor.

Child Dosage

Children’s experience is limited. As a result, until further data is available, Protonix 40mg Injection 1 vial is not recommended for use in individuals under the age of 18. 

Protonix 40mg Injection 1 vial is used in some cases to treat GERD in children who are at least 5 years old.

Elderly Dosage  

The elderly and individuals with a low body weight do not require any dosage adjustments. 

Pregnancy Use and Lactation

Because there is limited evidence on the use of Protonix 40mg Injection 1 vial during pregnancy, as a precautionary measure it should only be used if a doctor has recommended it. 

Protonix 40mg Injection 1 vial is a drug that can pass through breast milk. Avoid unless your doctor has recommended it. 

Contraindications

Before using Protonix 40mg Injection 1 vial, consult your doctor if you have a medical history of any of the following:

• Allergic/hypersensitive to Protonix 40mg Injection 1 vial and its contents
• If you are taking Rilpivirine for the treatment of HIV

Precautions

Please tell your doctor about any of the following conditions before using {{product}:

• Pregnancy and breast feeding
• Personal or family history of stomach cancer
• Avoid driving as you may feel dizzy and experience visual disturbances
• Avoid alcohol consumption as it may be associated with increased acid production
• Protonix 40mg Injection 1 vial may worsen the symptoms if you have a history of systemic lupus erythematosus, contact your doctor if you experience any rash, painful joints, or lesions on the skin.
• Protonix 40mg Injection 1 vial decreases your magnesium levels in the blood, contact your doctor if you experience dizziness, shivering, irregular heartbeat, muscle pain, seizures or shivering
• Long-term use of Protonix 40mg Injection 1 vial can decrease absorption of Calcium in the body leading to thinning of bones, weak and brittle bones, and thus increased risk of bone fractures. It is advisable to consume Vitamin D and calcium supplements while using this medicine

Interactions With Other Medications

Consult your doctor about the use of the following medicines before using Protonix 40mg Injection 1 vial:

• Neflinavinir
• Warfarin
• Digoxin 
• Methotrexate
• Atazanavir
• Ampicillin
• Medicines for fungal infections such as itraconazole and ketoconazole
• Iron salts

This document does not contain all probable drug reactions, it is advisable to keep a list of medicines in use and discuss it with your doctor (this includes prescription/nonprescription and herbal products). 

Adverse Effects

Rare Adverse Effects

Because Protonix 40mg Injection 1 vial may induce serious and fatal infusion responses followed by cardiac collapse, the following side effects may require rapid attention and report to your doctor:

• Signs of allergic reaction such as itching, hives, swelling of face, lips and tongue, etc.
• Chest pain/tightness
• Breathing problems
• Bone, joint, or muscle pain
• Dark yellow/brown urine
• Stomach polyps 
• Fast or irregular heartbeat
• Dizziness
• Feeling fainted or lightheaded
• Muscle spasm
• Palpitations
• Fever and sore throat
• Rash on arms and cheeks that gets worse in the sun
• Tiredness
• Unusual signs of bleeding or bruising
• Yellowing of eyes or skin

Common Adverse Effects

Following side effects may not require immediate medical attention until becomes troublesome:

• Constipation
• Dry mouth
• Diarrhea
• Headache
• Nausea
• Pain or inflamation at injection site

How To Cope with Some of The Adverse Effects

• Feeling or being sick (nausea or vomiting) or diarrhea –Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water.
• Headaches- In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
• Feeling dizzy (lightheaded) or weak –If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better and do not rise too fast or immediately from sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.
• Muscular Aches and Pains- A hot or cold compress can be placed at the area of discomfort to bring relief; an over-the-counter pain reliever such as paracetamol or ibuprofen can be ingested to bring ease as well. Avoid high-intensity exercise while suffering from muscular pain
• Skin Rash- can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. An antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.
• Soreness at the site of injection- a cold compress can be used for 5 minutes to ease out the soreness.
• Dry Mouth- Can be helped by sipping water throughout the day, chewing sugarless gum and using alcohol-free mouthwash, allowing ice to melt in the mouth, or using a saliva substitute.
• Sore throat – Can be eased by adding honey to warm drinks and having oral lozenges, to provide soothing relief to an irritated throat. Ginger tea has been known to decrease inflammation of an irritated throat thus, providing relief.

FAQs

#1. How to store Protonix 40mg Injection 1 vial?

Keep this drug out of children’s sight and reach. Do not use this drug after the expiration date, which is printed on the bottle and carton labels. Do not store below room temperature. 

Use as soon as possible after opening and/or dilution. This item is intended for one-time usage only. Any solution that has not been used should be discarded. 

Precipitation may form at chilly storage temperatures, but it will dissolve at normal temperatures. If you observe any visible particle matter or if the solution is hazy, do not use Protonix 40mg Injection 1 vial

#2. What is Protonix 40mg Injection 1 vial composed of?

Protonix 40mg Injection 1 vial contains Pantoprazole as an active ingredient.

#3. What if I take too much of Protonix 40mg Injection 1 vial?

If you’ve taken too much medicine, seek medical attention or call your doctor right away. 

#4. What if I miss a dose of Protonix 40mg Injection 1 vial?

Contact your doctor for any missed dose.

#5. Will Protonix 40mg Injection 1 vial affect my fertility??

Following some investigations, there was no evidence of diminished fertility concurrent the administration of Protonix 40mg Injection 1 vial. 

#6. Can I take Protonix 40mg Injection 1 vial during breastfeeding?

Protonix 40mg Injection 1 vial is a drug that can pass through breast milk. Avoid unless your doctor has recommended it. 

#7. How long does Protonix 40mg Injection 1 vial take to take effect?

Within 2-6 hours of dosing, Protonix 40mg Injection 1 vial reaches its peak effect. 

#8. What is the duration of this medicine’s effects? 

The impact of Protonix 40mg Injection 1 vial lasts for around 24 hours. 

#9. Is it okay to drink alcohol while taking Protonix 40mg Injection 1 vial? 

Alcohol hasn’t been tested for interaction however it can be associated with increased acid production. Before consuming, it is essential to seek medical advice. 

#10. Is Protonix 40mg Injection 1 vial a habit-forming medicine?

No, Protonix 40mg Injection 1 vial has been found to have no addictive properties. 

#11. What lab tests will be prescribed while treatment with Protonix 40mg Injection 1 vial?

Your doctor may prescribe you adjunct laboratory tests including magnesium levels in the blood at regular intervals.

#12. Why must I protect my skin from the sun while taking Protonix 40mg Injection 1 vial?

Treatment with Protonix 40mg Injection 1 vial may lead to the skin becoming sensitive to sun damage and it is therefore recommended to patients to always wear sunscreen, along with hats and gloves whenever possible to protect themselves from sun damage.

#13. Is it normal to feel lightheaded after getting injected with Protonix 40mg Injection 1 vial?

 Yes, If Protonix 40mg Injection 1 vial makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

#14. What dietary instructions are to be followed when using Protonix 40mg Injection 1 vial?

Continue to eat normally until your doctor tells you to switch to a specific diet.