Brytim 0.2%/0.5% Drop 5 ml

Description

About

High intraocular pressure is a condition that refers to elevated pressure states in the eyes. In general, our eyes produce a colorless, water-like fluid (aqueous humor) that helps sustain a balanced pressure inside the eyes while preserving the lens. For some reason, if the drainage pathway of this fluid is obstructed the fluid starts building inside, exerting pressure on the eyes. It may be seen in glaucoma or ocular hypertension (pressure greater than 21 mm Hg). The continued pressure can hurt your visual acuity. Brytim 0.2%/0.5% Drop 5 ml is a combination topical drug that belongs to a class of medicines known as alpha agonists and beta-blocker. This drug is prescribed to patients with high intraocular pressure usually seen in glaucoma or ocular hypertension. 

Brytim 0.2%/0.5% Drop 5 ml works by the combined action of alpha agonists (brimonidine) and beta-blocker (timolol) both of which helps in bringing down the raised pressure by controlling the amount of aqueous humor secreted. Brytim 0.2%/0.5% Drop 5 ml is a topical medicine to be administered directly into the eyes in form of drops, according to the prescribed dosage. Brytim 0.2%/0.5% Drop 5 ml is generally not prescribed to pregnant females due to toxic effects, unless considered necessary by your doctor. The recommended safe age for application of Brytim 0.2%/0.5% Drop 5 ml is above 17 years. In any case, children below 2 years of age are not to be prescribed Brytim 0.2%/0.5% Drop 5 ml due to the nonavailability of safety data.

Brytim 0.2%/0.5% Drop 5 ml is available in the form of eye drops to be applied topically directly into the affected eye. The generally prescribed dose is 1 drop per affected eye twice a day. Check below the method of application in detail and follow the steps. If you are wearing contact lenses remove them before application. Make sure not to exceed the prescribed number of drops. The most common side effects observed with Brytim 0.2%/0.5% Drop 5 ml are pain and irritation in the eyes, frequent tears, blurred vision, and a feeling of stickiness in the eyes among others. 

Indications

Brytim 0.2%/0.5% Drop 5 ml is prescribed for the management of:

Raised intraocular pressure (due to glaucoma/ ocular hypertension or other reasons)

How Does Brytim 0.2%/0.5% Drop 5 ml Work

Brytim 0.2%/0.5% Drop 5 ml is a chemical combination of 2 potent drugs, composed of Brominidine tartrate (alpha agonist) and timolol (beta-blocker). These two works in coherence with each other to help decrease the high pressure in the eyes. They do so by controlling the amount of fluid being secreted in the eyes which leads to a decrease in the buildup. Moreover, brimonidine is also thought to increase the discharge of this fluid via the uveoscleral pathway to further allow a reduction in this continued state of pressure. 

How to use Brytim 0.2%/0.5% Drop 5 ml

Brytim 0.2%/0.5% Drop 5 ml is available in the form of eye drops supplied in a dropper bottle, to be applied topically directly into the affected eye. In general, the dosage is prescribed as 1 drop per affected eye twice a day, keeping a 12-hour interval in between doses. The safe age for Brytim 0.2%/0.5% Drop 5 ml is above 17 years of age. Safety data is very limited in younger children. The safety concern is also present for pregnant and lactating mothers therefore always ask a doctor before using Brytim 0.2%/0.5% Drop 5 ml. Make sure not to exceed the prescribed number of drops, if you do immediately contact your doctor to avoid any side effects. 

In case other topical medicines have been prescribed to you for eyes, always keep a 5 to 10-minute gap between applications. And avoid putting back eye lenses for at least 15 to 20 minutes after using Brytim 0.2%/0.5% Drop 5 ml. Excess of Brytim 0.2%/0.5% Drop 5 ml may be wiped clean with a clean tissue or cloth. Brytim 0.2%/0.5% Drop 5 ml is not to be stopped abruptly even after experiencing a decrease in symptoms without consulting a physician.

How To Apply

Given below are the instructions for administering Brytim 0.2%/0.5% Drop 5 ml:

• Begin by washing your hand first, remove if you are wearing any contact lenses
• Shake the bottle vigorously to mix the constituents well
• Uncap the bottle, exposing the dropper tip which must not be touched by hand directly
• Tilt your head backward slightly such that your gaze is directed towards the roof, now gently pull down the lower eyelid creating a pocket and while keeping the dropper half to an inch away in the air, squeeze out 1 drop directly into your eye. The tip of Brytim 0.2%/0.5% Drop 5 ml must not touch any part of your eye
• Keep your eyes shut for a couple of minutes while maintaining the finger pressure at the inner corner of the eye to prevent a medicine from oozing out
• Make sure not to rub or open your eyes for a few minutes
• Place back the cap on the bottle after each use

Dosage form and Potency

Eye Drops (liquid) – Brimonidine Tartrate 0.2 % + Timolol 0.5 %

Dosage

Adult Dosage 

A drop in each eye is recommended for patients to be applied twice daily (at 12 hourly intervals)

Child Dosage 

Brytim 0.2%/0.5% Drop 5 ml is not recommended for patients under the age of 17 years of age

Elderly Dosage

Usually, 1 drop per affected eye is suggested to the elderly patients twice a day but due to decreased kidney and liver function, Brytim 0.2%/0.5% Drop 5 ml may not be effectively removed from the body and so, in such cases the doctor may prescribe an altered dose of the Brytim 0.2%/0.5% Drop 5 ml which must be strictly followed.

Pregnancy use and lactation

Brytim 0.2%/0.5% Drop 5 ml falls under FDA pregnancy category C which means it should not be taken during pregnancy due to potentially harmful effects on unborn babies. Therefore, if you are pregnant, or are planning to conceive a baby, please do discuss Brytim 0.2%/0.5% Drop 5 ml with your doctor. 

If you are breastfeeding an infant, ask your doctor first for some amount of medicine that may be secreted into breast milk. With regards to safety please make sure to consult your doctor to avoid any possible side effects for the baby. 

Contraindications

Please inform your doctor if you have a history of any before using Brytim 0.2%/0.5% Drop 5 ml:

• Allergy to Brytim 0.2%/0.5% Drop 5 ml 
• Pregnancy
• Liver impairment
• Currently taking antidepressants like MAO inhibitors, SSRIs, etc.
• Chronic lung diseases like asthma, COPD
• Heart conditions like a history of heart failure, etc.
• Underage children 

 Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Brytim 0.2%/0.5% Drop 5 ml:‌ 

• If there is a history of allergy to medicines or products that are maybe like ‌Brytim 0.2%/0.5% Drop 5 ml. Carefully read the contents of this product to avoid any future inconvenience 
• Before starting the treatment discuss with your doctor if you have a history of or recently diagnosed heart conditions such as heart failure, arrhythmias, etc.
• Adequacy of liver and kidney function must be ensured when taking ‌Brytim 0.2%/0.5% Drop 5 ml
• Diabetic patients taking antidiabetic drugs should be advised caution and monitored closely because Brytim 0.2%/0.5% Drop 5 ml is known to conceal symptoms of low blood sugar. Monitor your sugar levels regularly
• In case you have a thyroid condition, Brytim 0.2%/0.5% Drop 5 ml can hide the symptoms of hyperactive thyroid like tachycardia
• In case of a depressive disorder, if you are currently taking antidepressants, always tell your doctor since some of these may interact with Brytim 0.2%/0.5% Drop 5 ml negatively
• Avoid taking Brytim 0.2%/0.5% Drop 5 ml if you suffer from chronic lung disease such as asthma, bronchitis, breathing difficulties
• Raynaud’s phenomenon can occur if there are circulation problems, low blood circulation can cause this condition

Interaction with other medications

Certain medications could interact with Brytim 0.2%/0.5% Drop 5 ml and may increase or decrease its absorption. Make sure to inform your doctor about all the drugs you’re currently taking, in which case, your doctor might alter the treatment. 

• Beta-blockers 
• Anti-hypertensives 
• Calcium channel blockers
• Digoxin 
• MAO Inhibitors 
• TCAs 
• CNS depressants 

Adverse Effects

Common Adverse Effects

Like most medicines, Brytim 0.2%/0.5% Drop 5 ml has certain side effects which include:

• Dizziness 
• Headache 
• Pain in the eye 
• Dry eyes
• Stickiness of eyes 
• Frequent tears 

Less Common Side Effects

If any of the following adverse effects are seen or felt, the patient is advised to immediately contact their doctor.

• Anaphylactic reaction 
• Discharge from the eyes 
• Swelling of the eye 
• Eye irritation
• Blurred vision
• Fatigue 
• Fainting 
• Irregular heartbeat 
• Hypotension 

List Of How to Deal with Adverse Effects

• Blurred vision – This side effect tends to go away on its own if a few days; patients are advised to not operate heavy machinery or drive any motorized vehicles in the meantime. If blurred vision persists, please contact your doctor
• Fatigue – Patients experiencing this adverse effect, are advised to take deep breaths, intake tea or coffee, get a good night’s rest, and not overburden themselves for a few days.
• Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
• Feeling dizzy (lightheaded) or weak – If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

FAQs

#1.HOW TO STORE Brytim 0.2%/0.5% Drop 5 ml?

Brytim 0.2%/0.5% Drop 5 ml is to be kept away from the reach of children, in a cool dry place away from direct sunlight and humidity as that tends to ruin certain drugs.

#2. WHAT IF I MISS A DOSE OF Brytim 0.2%/0.5% Drop 5 ml?

If you miss a dose of the medication, make sure you take it as soon as possible on that same day. If you don’t remember you missed the dose until the next dosage time or the next day, do not double the dose and take your medication as per schedule.

#3. HOW IS Brytim 0.2%/0.5% Drop 5 ml SUPPOSED TO BE APPLIED?

Brytim 0.2%/0.5% Drop 5 ml must be applied with clean hands, make sure the eyedropper tip doesn’t touch the surface of the eye or any other surface. The tip of the dropper and hands must be always clean before the application of Brytim 0.2%/0.5% Drop 5 ml. Make sure to shake the Brytim 0.2%/0.5% Drop 5 ml container well before each use and to replace the cap of the Brytim 0.2%/0.5% Drop 5 ml immediately after each use.

To apply Brytim 0.2%/0.5% Drop 5 ml, pull the head back slightly, then pull down eyelid is pulled down to create a small space where a drop of solution from the tip is applied. A close eye for a minute or two after Brytim 0.2%/0.5% Drop 5 ml application, while applying pressure at the inner corner of the eye (area near the nose) to prevent the solution from draining out. Do not rub or blink after applying eye drops. If the recommended dosage is more than one drop of Brytim 0.2%/0.5% Drop 5 ml then the above steps are to be repeated.

#4. HOW DOES Brytim 0.2%/0.5% Drop 5 ml WORK?

Brytim 0.2%/0.5% Drop 5 ml can reduce the production of fluid (aqueous humor) in the eye as well as cause the drainage of aqueous humor from the eye, thereby decreasing the pressure 

#5.CAN Brytim 0.2%/0.5% Drop 5 ml BE USED DURING MY PREGNANCY?

Brytim 0.2%/0.5% Drop 5 ml should not be used during pregnancy and is only prescribed if considered necessary during pregnancy and under the care and supervision of a medical professional.

#6. WHAT ARE COMMON SIDE EFFECTS CAUSED BY Brytim 0.2%/0.5% Drop 5 ml?

• Blurred vision 
• Dry eyes
• Stinging of eyes 
• Burning sensation
• Headache 

#7. IS IT SAFE TO HAVE PAINKILLERS WHILE TAKING Brytim 0.2%/0.5% Drop 5 ml?

Yes, Over the counter painkillers such as paracetamol are safe to be ingested along with Brytim 0.2%/0.5% Drop 5 ml under the supervision of a doctor.

#8. IS IT SAFE TO HAVE Brytim 0.2%/0.5% Drop 5 ml ALONG WITH ORAL CONTRACEPTIVES?

Yes, there is no evidence to suggest that Brytim 0.2%/0.5% Drop 5 ml interacts with oral contraceptives.

#9. CAN OTHER EYE DROPS BE USED ALONG WITH Brytim 0.2%/0.5% Drop 5 ml?

Before applying any other eyedrop that might be prescribed along with Brytim 0.2%/0.5% Drop 5 ml, the patient is to wait 5 – 10 minutes. Brytim 0.2%/0.5% Drop 5 ml is recommended to be applied at the same time each day and for the recommended period. Excess of Brytim 0.2%/0.5% Drop 5 ml may be wiped clean with a clean tissue or cloth. 

#10. CAN CONTACT LENS BE WORN ALONG WITH Brytim 0.2%/0.5% Drop 5 ml?

There is a risk that Brytim 0.2%/0.5% Drop 5 ml usage may result in stains on contact lenses, and it is therefore advised to apply Brytim 0.2%/0.5% Drop 5 ml a minimum of 15 – 20 minutes before wearing the contact lenses. Brytim 0.2%/0.5% Drop 5 ml is available in eye drops. Intraocular pressures are to be routinely measured while undergoing treatment with Brytim 0.2%/0.5% Drop 5 ml by the doctor.

#11. CAN I DRIVE AFTER USING Brytim 0.2%/0.5% Drop 5 ml?

Brytim 0.2%/0.5% Drop 5 ml is known to disturb visual acuity and may cause irritation and frequent tearing. If this happens, try to avoid driving or using any heavy or sharp tools/machinery. Once the symptoms settle and you are sure about the visual accuracy you can drive.