Arynoin 10mg Capsule 10 ‘S

Categories: ,
Type

Capsule

Feature

10mg

Unit

'S

Formula

Isotretinoin

Composition

Isotretinoin 10 mg

Brand

Mass Pharma (Pvt) Ltd

Prescription Required

Yes

How to use, Side effects, Uses, Formula & Composition

Overview

{{Product}} (Isotretinoin) is a vitamin A derivative that is used to treat severe acne, specifically the one unresponsive to antibiotic therapy. 

Using Arynoin 10mg Capsule 10 ‘S is associated with a high risk of birth defects and premature abortion if taken by women of childbearing potential. Therefore, women with childbearing potential or who are breastfeeding must not use it. Pregnancy must be excluded and effective contraceptive measures should be taken one month before use.

How Does Arynoin 10mg Capsule 10 ‘S Work

{{Product}} contains Isotretinoin as an active ingredient that works by reducing the production of sebum, and inflammation, and ceases the growth of acne-causing bacteria. Acne is characterized by inflammatory lesions and the formation of comedones. Reducing the formation of comedones prevents the blockage of pores through the reduction of hyperkeratinization. {{Product}} is also known to reduce the size of sebaceous glands, thereby making the environment less likely for bacterial colonization.

Dosing and Indications

Nodular Acne (Unresponsive to conventional treatment)

The initial dose is 0.5mg/kg body weight for four weeks (single dose or in two divided doses) which can be adjusted from 0.1 to 1mg/kg body weight for 8 to 12 weeks depending upon the response. 

The second course of treatment can be initiated after two months of discontinuation if severe nodular acne reoccurs.

{{Product}} is not recommended for children and pregnant women.

How To Use {{Product}}

{{Product}} is recommended to be taken with the meal.

Side Effects

  • Dryness of skin
  • Dry eye and keratitis
  • Scaling of lips
  • Dry nose
  • Pruritis (skin irritation and itching)
  • Rash
  • Thinning of hair
  • Increased liver enzymes
  • Increased platelet count
  • Muscle pain
  • Visual disturbances and severe acne is expected at the start of therapy

Precautions

  • Pregnancy must be excluded before starting the treatment. Effective contraceptive measures must be taken one month prior.
  • Discontinue treatment if there are symptoms of pancreatitis.
  • Wax epilation and dermabrasion should be avoided at least 6 months before treatment.
  • Discontinue if there is severe diarrhea.
  • Blood donation should be avoided for a month after taking the last dose.
  • Wear sunscreen to avoid direct skin exposure to the sunlight.

Contraindications

  • Pregnancy (teratogenic)
  • Women of childbearing potential until pregnancy prevention is not carried out
  • Hyperlipidemia
  • Hypervitaminosis
  • Liver disease
  • Kidney disease
  • Soya or peanut allergy

Interactions

  • Tetracyclines (e.g. doxycycline, tigecycline)
  • Keratolytics (e.g. acitretin, zinc, salicylic acid)
  • Exfoliative anti-acne medications
  • High-dose vitamin A

FAQ’s

  • IS ALCOHOL INTAKE SAFE DURING THE TREATMENT WITH {{Product}}?

Alcohol consumption should be avoided during the treatment as there is a risk of elevated liver enzymes and high levels of cholesterol with the use of Arynoin 10mg Capsule 10 ‘S.

  • IS {{Product}} SAFE TO BE USED BY BREASTFEEDING MOTHER?

Studies are not adequate to determine the risk to the infant. {{Product}} should only be given to a breastfeeding mother upon outweighing the potential benefits and risks.

  • CAN {{Product}} INCREASE THE RISK OF SUNBURN?

{{Product}} can make the skin more sensitive to sun damage. The chances of getting sunburn increase with its use. Therefore, extra care must be taken while moving outdoors when you are on this medication.

  • IS {{PRODUCT}} SAFE TO USE IN TEENAGERS?

{{Product}} can be given to teenagers with caution specifically to those with active bone disease. Teens who are on antidepressants and have moderate to severe acne can also be treated with Arynoin 10mg Capsule 10 ‘S.