Adrenaline 1mg/ml Injection 1 ml

Description

 About

Adrenaline 1mg/ml Injection 1 ml is a direct-acting sympathomimetic agent that mimics the effects of the sympathetic nervous system. Adrenaline 1mg/ml Injection 1 ml comes in injection form and is usually administered intramuscularly. Adrenaline 1mg/ml Injection 1 ml comes from a class of medications called alpha and beta-adrenergic agonists. 

It is used to treat life-threatening allergic reactions that are caused by insect bites, foods, medications, and other causes. Adrenaline 1mg/ml Injection 1 ml is also used in the treatment of shock caused due to severe allergic reactions.  {{products}} might cause side effects such as allergic reactions and any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body).

 Indications

 Adrenaline 1mg/ml Injection 1 ml is indicated for:

• Emergency treatment of type I allergic reactions, including anaphylaxis.
• Adrenaline 1mg/ml Injection 1 ml is used to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.
• Adrenaline 1mg/ml Injection 1 ml may be used in restoring cardiac rhythm in cardiac arrest due to various causes.
• Adrenaline 1mg/ml Injection 1 ml is used as a hemostatic agent.
• Adrenaline 1mg/ml Injection 1 ml is used in treating mucosal congestion of hay fever, rhinitis, and acute sinusitis; to relieve bronchial asthmatic paroxysms
• Adrenaline 1mg/ml Injection 1 ml is used in syncope due to complete heart block or carotid sinus hypersensitivity
• Adrenaline 1mg/ml Injection 1 ml is used in simple (open-angle) glaucoma
• Adrenaline 1mg/ml Injection 1 ml is used for relaxation of uterine musculature and to inhibit uterine contractions. 
• Adrenaline 1mg/ml Injection 1 ml is used as an over-the-counter (OTC) agent for the intermittent symptoms of asthma, such as wheezing, tightness of the chest, and shortness of breath.
• Adrenaline 1mg/ml Injection 1 ml is also used for the maintenance of mydriasis during intraocular surgery. 

How does Adrenaline 1mg/ml Injection 1 ml work?

Adrenaline 1mg/ml Injection 1 ml acts on alpha and beta-adrenergic receptors. Adrenaline 1mg/ml Injection 1 ml acts on alpha and beta receptors and is the strongest alpha receptor activator. Through its action on alpha-adrenergic receptors, Adrenaline 1mg/ml Injection 1 ml minimizes vasodilation and increases vascular permeability. Adrenaline 1mg/ml Injection 1 ml relaxes the smooth muscle of the bronchi and iris and is a histamine antagonist, making it useful in treating the effects of allergic reactions. Through its action on beta-adrenergic receptors, Adrenaline 1mg/ml Injection 1 ml leads to bronchial smooth muscle relaxation that helps to relieve bronchospasm, wheezing, and dyspnea that may occur during anaphylaxis reactions.

 How to use Adrenaline 1mg/ml Injection 1 ml?

The doctor will administer Adrenaline 1mg/ml Injection 1 ml into a muscle (Intramuscular – IM), however, in emergencies your doctor may give you a diluted injection into your vein (intravenous – IV). Adrenaline 1mg/ml Injection 1 ml must NOT be given in areas such as fingers, toes, ears, nose, genitalia, or buttocks, as the blood supply to these areas might become inadequate.

Dosage

Adults

The usual dose is 0.5ml. If necessary, this dose may be repeated several times at 5-minute intervals.

Elderly

There are no specific dose changes in elderly patients, however, Adrenaline 1mg/ml Injection 1 ml should be used with great caution. 

Children 

The following doses of Adrenaline Solution for Injection are recommended:

• Over 12 years: 0.5 mg IM (0.5ml 1mg/ml solution) 0.3 mg IM (0.3ml 1mg/ml solution) if the child is small or pre-pubertal)
• 6 – 12 years: 0.3 mg IM (0.3ml 1mg/ml solution) 
• 6 months – 6 years: 0.15 mg IM (0.15ml 1mg/ml solution) 
• Under 6 months: 0.01mg/kg IM (0.01ml/kg 1mg/ ml solution)

Pregnancy and lactation

If you are pregnant or breastfeeding, or think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using the Adrenaline 1mg/ml Injection 1 ml. Adrenaline 1mg/ml Injection 1 ml should only be used during pregnancy and breastfeeding if considered essential by your doctor.

Contraindications

{product}} should not be used in people who are: 

• Allergic to Adrenaline 1mg/ml Injection 1 ml or any of the active ingredients
• Adrenaline 1mg/ml Injection 1 ml should not be used in areas such as fingers, toes, ears, nose, genitalia, or buttocks, as the blood supply to these areas might become inadequate.

 Precautions

Talk to your doctor or pharmacist or nurse before using Adrenaline 1mg/ml Injection 1 ml if:

• you are elderly 
• you suffer from any heart problem, particularly if it affects the heart rate or if you suffer from chest pain 
• you have problems with your brain e.g. stroke, brain damage, or blood vessel disease 
• you have an overactive thyroid, diabetes, or glaucoma (high pressure in the eye)
• you have phaeochromocytoma (a tumor on the adrenal gland) you have a tumor on your prostate gland or kidney disease.
• you are in shock or have lost a lot of blood
• you are going to have surgery under general anesthesia
• you are suffering from high blood pressure
• you have atherosclerosis, a narrowing and hardening of the body’s blood vessels (your doctor will advise you).
• you have low blood levels of potassium or high blood levels of calcium 
• you have a tumor on your prostate gland or kidney disease
• you are in shock or have lost a lot of blood 
• you are going to have surgery under general anesthesia 
• you are suffering from high blood pressure 
• you have atherosclerosis, a narrowing and hardening of the body’s blood vessels (your doctor will advise you).

 Interaction with other medications

A large number of drugs can interact with Adrenaline 1mg/ml Injection 1 ml which can significantly alter their effects. These drugs include: 

• monoamine oxidase inhibitors (MAOI) or tricyclic antidepressants such as imipramine, amitriptyline, both used for depression
• cardiac glycosides such as digoxin, used for heart failure
• guanethidine, used for the rapid control of blood pressure
• diuretics (“water tablets”) such as hydrochlorothiazide, furosemide
• inhaled general anesthetics, such as halothane
• medicines to raise or lower your blood pressure including beta-blockers, e.g. propranolol, atenolol, bisoprolol, phentolamine
• anti-diabetic drugs like insulin or oral hypoglycaemic agents (e.g. glipizide)
• aminophylline and theophylline (medicines to help you breathe)
• corticosteroids (medicines used to treat inflammatory conditions in your body such as asthma or arthritis)
• antihistamines (for example diphenhydramine), used for the treatment of allergies
• medicines used to treat mental illness like chlorpromazine, pericyazine, or fluphenazine
• medicines used to treat an underactive thyroid gland
• oxytocin (used to induce labor at term and to control bleeding after delivery)
• any cough or cold remedies (sympathomimetics).

 Adverse effects

If you experience any of the following side effects, stop taking this medicine and report to a doctor immediately:

• allergic reactions although serious allergic reactions are rare
• any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash, or itching (especially affecting your whole body).
• symptoms of chest pain, shortness of breath, nausea, or an irregular heartbeat. 

Other side effects

• headache
• Necrosis at the site of injection
• dizziness
• feelings of anxiety or fear or restlessness
• insomnia, confusion, irritability
• abnormal mood or behavior
• a dry mouth or producing too much saliva
• high blood pressure
• breathlessness
• reduced appetite, feeling sick, or being sick
• metabolic acidosis
• bleeding in the head
• paralysis of one half of the body
• increased sugar levels in the blood.

How to cope with side effects

• Allergic Reactions: This Adrenaline 1mg/ml Injection 1 ml contains Sodium Metabisulphite which may cause allergic (hypersensitive) type reactions in some people, which can lead to breathing difficulties or collapse. People with a history of asthma or allergies (hypersensitivity) are most likely to experience these problems. Contact your doctor or pharmacist if you face adverse effects such as hypersensitivity reactions.
• Difficulty In Breathing: If you face sudden wheezing, difficulty in breathing, or sudden swelling of the face or whole body rush to the emergency. 
• Chest Pain: Rush to the emergency if you face chest pain, shortness of breath, or irregular breathing after using Adrenaline 1mg/ml Injection 1 ml. 

FAQ’S

• WHAT IS {{PRODUCT}} USED FOR?

Adrenaline 1mg/ml Injection 1 ml is used to treat severe allergic reactions or shock caused by allergic reactions.

• IN WHICH DOSAGE FORM IS {{PRODUCT}} AVAILABLE?

{{PRODUCT}} is available in injection form.

• HOW LONG DOES IT TAKE FOR {{PRODUCT}} TO START WORKING?

Adrenaline 1mg/ml Injection 1 ml is a rapid-acting drug.

• WHAT WILL HAPPEN IF I STOP TAKING THE {{PRODUCT}} IMMEDIATELY?

Adrenaline 1mg/ml Injection 1 ml should not be stopped immediately as it may cause rebound effects.

• HOW SAFE IS {{PRODUCT}}?

{{PRODUCT}} is safe and well-tolerated. 

• HOW IS {{PRODUCT}} TAKEN?

{{PRODUCT}} is usually administered via the intramuscular route as absorption is faster from the IM route. 

• CAN {{PRODUCT}} AFFECT FERTILITY?

Consult your doctor before using Adrenaline 1mg/ml Injection 1 ml if you are planning a pregnancy. 

• HOW DOES {{PRODUCT}} WORK?

{{PRODUCT}} is a sympathomimetic drug that mimics the effects of the sympathetic nervous system. 

• WHAT HAPPENS WHEN {{PRODUCT}} OVERDOSAGE OCCURS?
  Overdosage of Adrenaline 1mg/ml Injection 1 ml causes systolic and diastolic blood pressure to rise sharply; venous pressure also rises. Cerebrovascular or other hemorrhages and hemiplegia may result, especially in elderly patients. Pulmonary edema may occur. Adrenaline 1mg/ml Injection 1 ml overdosage causes transient bradycardia.
• HOW TO TREAT {{PRODUCT}} OVERDOSAGE?

Overdosage is treated by supportive measures because Adrenaline 1mg/ml Injection 1 ml is rapidly inactivated in the body. The pressor effects of Adrenaline 1mg/ml Injection 1 ml may be counteracted by an immediate intravenous injection of a quick-acting Alpha-adrenoreceptor blocking agent such as phentolamine mesylate, followed by a beta-adrenoreceptor blocking agent such as propranolol. Arrhythmias, if they occur, maybe counteracted by propranolol injection.

• WHAT HAPPENS WHEN YOU FORGET TO TAKE {{PRODUCT}}?

If you forget to take a dose of Adrenaline 1mg/ml Injection 1 ml, then take it as soon as you remember. if it is time for the next dose skip the missed dose. Do not take a double dose.

• IS IT SAFE TO TAKE {{PRODUCT}} DURING PREGNANCY?

Adrenaline 1mg/ml Injection 1 ml should only be used during pregnancy if your doctor considers it essential. 

• CAN YOU CONSUME ALCOHOL AFTER THE {{PRODUCT}} SHOT?

Alcohol should generally be avoided as it may aggravate the pharmacologic effects of CNS-active agents. Alcohol consumption may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

• CAN I DRIVE OR RIDE A BIKE AFTER TAKING {{PRODUCT}}?

You should not drive or use machinery if you are affected by the administration Adrenaline 1mg/ml Injection 1 ml. 

• HOW SHOULD {{PRODUCT}} BE STORED?

Keep Adrenaline 1mg/ml Injection 1 ml out of the reach of children. Do not store above 25°C. Do not freeze the Adrenaline 1mg/ml Injection 1 ml. You should not be given Adrenaline 1mg/ml Injection 1 ml if it has been partly used or shows signs of visible damage such as color change.