Synephrine 10mg/ml Ampule 1 ml

Description

Overview 

Blood pressure lower than usual (120/80 mmHg) can occur for several reasons, one of which can be attributed to the widening of blood vessels producing a sudden drop or a shock. There is a need to revive the average pressure in these patients.  Synephrine 10mg/ml Ampule 1 ml is an injectable solution used to manage low blood pressure. 

How Does Synephrine 10mg/ml Ampule 1 ml Work

Synephrine 10mg/ml Ampule 1 ml is chemically composed of Phenylephrine, an alpha-1 agonist that works by enhancing the action of this receptor and effects are dependent on the route by which it is taken. Taking it intravenously produces narrowing (constriction) of blood vessels that exerts pressure on the vessel’s wall, raising it. 

Dosing and Indications

Synephrine 10mg/ml Ampule 1 ml can be used to treat:

• Severe Hypotension 

• Shock-like states 

• Drug-induced hypotension 

Adult Dose

Hypotension

Starting dose: An injection of 2 to 5 mg, intramuscularly or subcutaneously, not more than 5 mg

IV Dose

IV bolus: 40 to 100 mcg, giving an additional amount if needed every 1 to 2 minutes

Do not give more than 200 mcg 

IV injection should not be readministered sooner every 15 minutes if needed

Slow IV Infusion: If hypotension is uncontrolled, give Synephrine 10mg/ml Ampule 1 ml via continuous infusion at a rate of 10 to 35 mcg/minute; not to exceed 180 mcg/minute.

Gradually decrease the dose to 30 to 60 mcg/minute.

Paroxysmal Supraventricular Tachycardia: 250 to 500 mcg/minute over 20 to 30 seconds, adjusted as per need

Child Dose

Synephrine 10mg/ml Ampule 1 ml is not given to children below 2 years of age.

2 years and above: Given intravenously 5 to 10 mcg/kg IV once, followed by 0.1 to 0.5 mcg/kg/min IV

Do  not give more than 3 to 5 mcg/kg/min IV

Elderly Dose

Consult a doctor

How To Use Synephrine 10mg/ml Ampule 1 ml

{product}} is an injectable solution that is given intravenously by a healthcare provider in a hospital. Alternatively, it can also be injected into the muscles (IM) or under the skin (subcutaneously). For infusion purposes Synephrine 10mg/ml Ampule 1 ml can be diluted with some compatible IV solutions like dextrose. Continuous mentoring of blood pressure is advised, and dose adjustment is done accordingly. Sterility of the environment and handling must be ensured. 

Side Effects

Inform your healthcare supervisor immediately, if you notice any of the following symptoms :

• Pain or bruising at the injection site 

• Allergic reaction

• Reflex bradycardia 

• Dilated pupils (affecting vision)

• Breathlessness 

• Abdominal pain 

• Visual disturbance

• Skin rash 

• Irregularities in heart rate 

• Restlessness 

• Exacerbation of angina/ heart attack 

• Sweating 

• High blood pressure 

• Fluid buildup in the lungs

• Increased salivation 

Contraindications

Please tell your doctor if you have a history of any of the following before using Synephrine 10mg/ml Ampule 1 ml:

• Hypersensitivity to Synephrine 10mg/ml Ampule 1 ml

• Severe cardiac dysfunction 

• Hypovolemia 

• Autonomic dysfunction 

Precautions

Please tell your doctor about any of the following conditions before using Synephrine 10mg/ml Ampule 1 ml:

• Synephrine 10mg/ml Ampule 1 ml must be used with caution if you have a history of drug-related allergies

• With increased blood pressure in patients with a history of angina or artery blockage, may precipitate angina or blood pressure 

• Sloughing of the skin or tissue occurs due to necrosis if Synephrine 10mg/ml Ampule 1 ml is extravasated when available use central venous catheters 

• Caution should be practiced with regular monitoring of blood pressure, it can cause bradycardia 

• Adequacy of liver and kidney function must be ensured before taking Synephrine 10mg/ml Ampule 1 ml

• A sharp rise in blood pressure may occur especially in patients with autonomic dysfunction, extreme caution is advised

• For infusion purposes Synephrine 10mg/ml Ampule 1 ml is diluted with a compatible solution like dextrose water

Interactions With Other Medications

Always provide correct information to the doctor about all the drugs you are currently taking. Following drugs may interact with Synephrine 10mg/ml Ampule 1 ml, a few of which are: 

• Psychostimulants like atomoxetine

• Steroids like hydrocortisone 

• Anticholinergics like atropine 

•  Oxytocic drugs/oxytocin 

• MAO inhibitors like Selegiline 

• Tricyclic antidepressants like Amitriptyline, doxepin

• SNRIs like Atomoxetine

• Angiotensin / aldosterone 

• Calcium channel blockers like nifedipine 

• Benzodiazepines like diazepam 

• Alpha-adrenergic blockers like prazosin 

• ACE inhibitors like Captopril

• Sympatholytic agents like reserpine  

FAQs

#1. How To Store Synephrine 10mg/ml Ampule 1 ml?

Synephrine 10mg/ml Ampule 1 ml is to be kept away from the reach of children and pets, in a cool dry, and dark place at 20 to 25°C, away from direct sunlight and humidity. Do not freeze this medicine. Once open make sure to use the medicine at once. 

#2. Can I take Synephrine 10mg/ml Ampule 1 ml during my pregnancy?

Synephrine 10mg/ml Ampule 1 ml is not prescribed during pregnancy due to safety concerns. Your doctor will outweigh the merits of using this product first in this condition. 

#3. Which Laboratory Test Will I Have to Undertake While Taking  Synephrine 10mg/ml Ampule 1 ml?

Synephrine 10mg/ml Ampule 1 ml is infused IM, SC, or intravenously while keeping a strict check on B.P and heart function with ECG and hemodynamic status. Other tests may include blood serum electrolytes, blood sugar, etc.

#4. What If I Receive an Excess Amount Of Synephrine 10mg/ml Ampule 1 ml?

Although it is unlikely to overdose since Synephrine 10mg/ml Ampule 1 ml is given in a hospital with regular monitoring, signs of overdose become apparent in the form of tremors, heartbeat changes, and breathing difficulties. In this case, call the doctor and its side effects should be treated at once. 

#5. Can Synephrine 10mg/ml Ampule 1 ml Be Given To The Elderly? 

Synephrine 10mg/ml Ampule 1 ml should be used cautiously in this age group. Usually, it is started on a lower dose and adjusted accordingly.