Hydralazine 25mg Tablet 10 ‘S

Description

About

Hydralazine 25mg Tablet 10 ‘S is a drug that belongs to a class of medicines known as “Antihypertensives”. This drug is prescribed to patients with high blood pressure (normal blood pressure for adults is usually 120/80 mmHg.  Hypertension if left untreated can cause severe damage to the brain, heart, kidney, blood vessels, and other body organs and may have life-threatening consequences. Hydralazine 25mg Tablet 10 ‘S is beneficial in cases of hypertensive emergency and pregnant women showing symptoms of eclampsia. 

Hydralazine 25mg Tablet 10 ‘S is chemically composed of Hydralazine, an agent that induces the widening of blood vessels through a relaxation mechanism and consequently decreases the pressure within the vessels causing high blood pressure.  Treatment with Hydralazine 25mg Tablet 10 ‘S is generally prescribed for longer periods of time. It starts showing clinical effects after 30 minutes of taking it and must not be stopped all of a sudden without prior consultation with a doctor. 

Hydralazine 25mg Tablet 10 ‘S  is available in form of oral tablets to be taken 2 to 3 times per day. It is commonly prescribed to patients to be swallowed with water. Hydralazine 25mg Tablet 10 ‘S is to be taken regularly, preferably at the same time each day to help the patient remember their daily dose.

Hydralazine 25mg Tablet 10 ‘S was used to manage hypertension in pregnant females in the past but with the availability of other alternatives, it is not considered safe during the first and last 3 months of pregnancy and breastfeeding. Moreover, Hydralazine 25mg Tablet 10 ‘S carries an unknown safety risk in children. The most common side effects observed with Hydralazine 25mg Tablet 10 ‘S include low blood pressure, palpitations, flushing, dizziness, and skin rash. 

Indications

Hydralazine 25mg Tablet 10 ‘S is prescribed for the management of :

• Essential Hypertension
• Hypertensive crisis 
• Congestive heart failure 

How Does Hydralazine 25mg Tablet 10 ‘S Work

Hydralazine 25mg Tablet 10 ‘S is chemically composed of Hydralazine, which helps bring down blood pressure. Several working mechanisms have been suggested but the exact one is still uncertain. Hydralazine 25mg Tablet 10 ‘S is thought to exert relaxing effects on the musculature of blood vessels. Hydralazine 25mg Tablet 10 ‘S cause the tone of vessels to decrease, widen and be in a relaxed state. It also decreases the oxygen requirement needed by the heart muscle. The overall effect manifests in a decrease in high blood pressure and heart rate.  

How To Use {{Product}}

Hydralazine 25mg Tablet 10 ‘S is available in form of oral tablets, to be swallowed with a glass of water without chewing or breaking into half. Its dose is recommended by the patient’s condition under treatment and may be given 2 to 4 times per day. Hydralazine 25mg Tablet 10 ‘S should be ingested only as directed by the medical expert. The medicine should be consumed daily, if another medicine is recommended along with Hydralazine 25mg Tablet 10 ‘S by the doctor then it should not be forgotten.  

Hydralazine 25mg Tablet 10 ‘S is not considered safe for use in children due to insufficient scientific data available. It stays in the blood for a brief period, hence multiple doses are taken during the day. Do not stop taking the medicine without consulting a doctor first. In general, Hydralazine 25mg Tablet 10 ‘S is stopped slowly over days to weeks, as advised by the doctor. 

Dosage Forms And Potency

Tablets – 25 mg

Dosage

Adult Dosage

Hypertension

Starting Dose: 10 mg given orally 4 times a day, every 6 hours for 2 to 4 days

Dose adjustment: 10 to 25 mg may be increased per dose up to a total of 50 mg orally, every 6 hours. Adjustment is done every 2 to 4 days while monitoring the response

Maximum Dose: 200 to 300 mg per day

Congestive heart failure

Used as a combination medicine with nitrates in heart failure,

Starting Dose: 10 to 25 mg given orally, every 6 to 8 hours

Adjustment is done every 2 to 4 weeks while monitoring the response

Maintenance dose: 225-300 mg/day given orally, every 6 to 8 hours

Essential Hypertension

Starting Dose: 10 mg given orally 4 times a day, every 6 hours for 2 to 4 days

First week:  increase the dose to  25 mg given orally, every 6 to 8 hours

Second Week: 50 mg orally, every 6 hours

Dose adjustment: Adjust to a minimally effective dose

Child dosage

Hydralazine 25mg Tablet 10 ‘S is not prescribed to children due to insufficient scientific evidence regarding safety

In cases where it may be prescribed like heart failure and afterload reduction, the oral dose will be decided by the doctor considering certain factors. IM and IV forms can be administered in prescribed doses in a hospital setting

Elderly Dosage

Dosage in the elderly population is dependent on several factors. Caution is advised with regards to long-standing heart and liver conditions, as well as other co-morbidities. Always consult a physician first. 

Pregnancy Use And Lactation

Hydralazine 25mg Tablet 10 ‘S is categorized as FDA pregnancy category C which means it should not be taken during pregnancy due to potentially harmful effects on unborn babies. Therefore if you are pregnant, or are planning to conceive a baby, please do discuss Hydralazine 25mg Tablet 10 ‘S with your doctor before using it. 

If you are breastfeeding an infant ask your doctor first, for some amount of medicine is secreted into the breast milk. With regards to safety please make sure to consult your doctor first before using it. 

Contraindications

Please tell your doctor if you have a history of any of the following before using Hydralazine 25mg Tablet 10 ‘S:

• Hypersensitivity to Hydralazine 25mg Tablet 10 ‘S  or similar drugs 
• Systemic Lupus erythematosus 
• Cor- pulmonale 
• Severe tachycardia 
• Thyrotoxicosis 
• Porphyria 
• Chronic heart condition (myocardial insufficiency)
• Bradycardia

Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ before starting or during the treatment with ‌Hydralazine 25mg Tablet 10 ‘S:‌ 

• If there is a history of allergy to medicines or products. Carefully read the contents of this product to avoid any future inconvenience 
• Adequacy of liver and kidney functions must be ensured
• Patients with a chronic history of heart diseases such as a history of a heart attack in the last 3 months (see contraindications) must take this medicine strictly under a doctor’s supervision
• Care must be exercised if you have a history of stroke or cerebrovascular disease 
• Patients whose bodies process the medicines slowly should be monitored carefully. Dose adjustment may be required  
• History of coronary artery disease (CAD) (obstructed vessel/vessels)
• Regular monitoring of blood pressure is advised at home
• Hydralazine 25mg Tablet 10 ‘S may be given in combination with other drugs, do not miss out on other medicines
• Taking Hydralazine 25mg Tablet 10 ‘S with meals can lead to raised levels in plasma. Preferably Hydralazine 25mg Tablet 10 ‘S should be taken with a glass of water
• Hydralazine 25mg Tablet 10 ‘S when taken with other antihypertensives can cause a drop in blood pressure. Caution is advised 
• Caution is advised when taking Hydralazine 25mg Tablet 10 ‘S with analgesics or NSAIDs due to possible interactions. Over the counter painkiller like paracetamol may be taken
• Sodium-restricted diet along with other lifestyle changes will help you with the condition

Interaction With Other Medicines

Certain medications could interact with Hydralazine 25mg Tablet 10 ‘S and may increase or decrease its absorption, in which case, your doctor might alter your dosage. A few of these interacting drugs are given below:

• Antidepressants like MAO Inhibitors (isocarboxazid)
• ACE inhibitors like enalapril
• Linezolid 
• Metaxalone
• Methylene blue 
• moclobemide
• Phenelzine
• Procarbazine
• Rasagiline
• Safinamide
• Selegiline
• Tranylcyclopomine
• Alcohol 
• Atrovastatin/ Rosuvastatin 
• Metoprolol 
• Aspirin 
• Levodopa 
• Tranquilizers like haloperidol
• Diazoxide  
• Epinephrine 
• Anesthetics 
• NSAIDs like ibuprofen, indomethacin 
• Estrogen 

Adverse Effects

  Common Side Effects

• Nausea 
• Headache
• Hypotension 
• Palpitations 
• Chest pain/ chest tightness 
• Flushing  
• Pounding of heart 
• Lightheadedness 
• Skin rash/itching 

Less Common Side Effects

• Anaphylactic reaction
• Jaw pain 
• Visual disturbances 
• Mood changes 
• Peripheral edema 
• Peripheral neuropathy 
• Dysuria 
• Breathing difficulty 
• Thrombocytopenia 
• SLE like symptoms 
• Arthralgia / joint pains
• Agranulocytosis
• Liver toxicity 
• Loss of appetite 

 How To Cope-Up With Some Adverse Effects

• Allergic Reactions – Allergic reactions to the drug may be mild to severe or potentially could be life-threatening. If allergy is suspected immediately take anti-allergy (antihistamine) medicine which will stop the mild reaction. If a serious allergic reaction is suspected, rush to the nearby hospital and avoid Hydralazine 25mg Tablet 10 ‘S and drugs with similar compounds in the future.
• Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe
• Constipation – Can be combated by adding more fibers to the patient’s diet, asking the patient to drink plenty of fluids, and increasing their physical activity to trigger contractions in the intestines.
• Feeling or being sick (nausea or vomiting) or diarrhea – Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water. 
• Feeling dizzy (lightheaded) or weak – If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.
• Blurred vision – This side effect tends to go away on its own if a few days; patients are advised not to operate heavy machinery or drive any motorized vehicles in the meantime.If blurred vision persists, please contact your doctor.
• Muscular Aches And Pains – A hot or cold compress can be placed at the area of discomfort to bring relief; an over-the-counter pain reliever such as paracetamol or ibuprofen can be ingested to bring ease as well. Avoid high-intensity exercise while suffering from muscular pain.
• Skin Rash – Can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash helps reduce itchiness and redness caused by the rash. An antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.

FAQ’s

#1. CAN LIFESTYLE CHANGES HELP ME WITH MY CONDITION?

Yes, you can adopt certain healthy lifestyle changes to help with high blood pressure. These include quitting smoking, avoiding alcohol, eating a wholesome diet consisting of fresh vegetables and fruits with the cut down on salt, and incorporating physical activity into your daily routine.

#2. WHAT EXACTLY DOES Hydralazine 25mg Tablet 10 ‘S DO?

Hydralazine 25mg Tablet 10 ‘S controls the tone of the blood vessel by relaxing the walls, causing the pressure within to drop. It also decreases the oxygen requirement needed by the heart muscle. The overall effect is manifested in form of a decrease in high blood pressure and heart rate. 

#3. WHAT IF I TAKE TOO MUCH OF Hydralazine 25mg Tablet 10 ‘S?

In case of too much consumption by accident, kindly contact your doctor or nearby hospital straight away. The amount of medication that can result in severe side effects varies from person to person. An overdose results in slowing down of heart rate and difficulty breathing accompanied by dizziness and fainting spells. 

#4. HOW TO STORE Hydralazine 25mg Tablet 10 ‘S?

Hydralazine 25mg Tablet 10 ‘S is to be kept away from the reach of children, in a cool dry place away from direct sunlight and humidity as that tends to ruin certain drugs.

#5. CAN I CONSUME ALCOHOL WITH Hydralazine 25mg Tablet 10 ‘S?

Alcohol is also known to lower your blood pressure which if taken with the medication may lead to extreme dizziness. Hydralazine 25mg Tablet 10 ‘S also interacts with alcohol so it is best to avoid the intake of alcohol during your treatment.

#6. WHAT IF I FORGET TO TAKE THE Hydralazine 25mg Tablet 10 ‘S?

It is advised that the drug is taken at the same time each day, and an alarm can be placed to remind patients to take Hydralazine 25mg Tablet 10 ‘S at the proper time. If the patient misses a dose of Hydralazine 25mg Tablet 10 ‘S, they should take it immediately but if the time for the next dose of the drug is near then it is beneficial for patients to skip the missed dose and take the tablets as per schedule, doubling of doses has proven to cause severe side effects. 

#7. CAN Hydralazine 25mg Tablet 10 ‘S CAUSE DIZZINESS? IF SO, HOW SHOULD I MANAGE IT?

Yes. It can cause dizziness as one of the most common side effects. If this happens, you should sit or lie down until the symptoms pass. However, please note this is temporary and usually goes away as the treatment continues. It is also advised to avoid the consumption of alcohol during your treatment, as it may worsen the dizziness.

#8. CAN I DRIVE AFTER TAKING THIS MEDICATION?

This medication is known to make you dizzy hence if that happens kindly avoid driving or operating any heavy machinery.

#9. IS Hydralazine 25mg Tablet 10 ‘S SAFE TO GIVE TO ELDERLY PATIENTS?

Although there are no particular guidelines, for elderly patients the dosage of the drug may be lower than normal due to decreased kidney and liver function. Discuss with your doctor.

#10. CAN Hydralazine 25mg Tablet 10 ‘S INTERFERE WITH FERTILITY?

There is no evidence to support the above statement. If a patient does become pregnant it is imperative that they inform their doctor immediately as Hydralazine 25mg Tablet 10 ‘S can have fatal effects on the developing fetus.