Danocrine 100mg Capsule 30 ‘S

Danocrine 100mg Capsule 30 ‘S contains Danazol as an active ingredient.

Danocrine 100mg Capsule 30 ‘S is prescribed to women diagnosed with endometriosis, fibrocystic breast disease and hereditary angioedema.

Take this medication by mouth with or without meals.

Danocrine 100mg Capsule 30 ‘S is available as capsules.

Categories: , , , ,
Type

Capsule

Feature

100mg

Unit

'S

Formula

Danazol

Composition

Danazol 100 mg

Brand

Sanofi-aventis

Prescription Required

Yes

How to use, Side effects, Uses, Formula & Composition

About

Endometriosis is an extremely painful condition affecting the uterus in women. It is manifested clinically in the form of severe menstrual pain, bleeding after periods have stopped, infertility, heavy bleeding during menses, and discomfort/pain during urination/defecation. The most common age group affected with this condition is between 25 to 35 years of age. Danocrine 100mg Capsule 30 ‘S is a hormonal medicine that belongs to a class of medicines called “Androgens” or gonadotropin inhibitors. Danocrine 100mg Capsule 30 ‘S is used to treat painful conditions like endometriosis as well as other gynecological problems like fibrocystic breast disease, breast tenderness, and menorrhagia. ‌Danocrine 100mg Capsule 30 ‘S can be used to treat hereditary angioedema in men.

Danocrine 100mg Capsule 30 ‘S is chemically composed of Danazol that works by subduing the function of the pituitary gland involved in the release of gonadotropins which regulate the function of ovaries, decreasing the synthesis of estrogen by ovaries. Another mechanism that is thought to work is the degeneration of extra tissue of endometriosis by atrophy via the secretion of certain antibodies IgM, IgA, and IgG. It also influences breast tissues which help with breast conditions. Danocrine 100mg Capsule 30 ‘S takes some time to show clinical improvement. In about a month, the patient starts feeling better but full benefits can be seen in 3 to 4 months or sometimes longer. 

This medicine is available in the form of oral capsules to be taken by mouth with or without food. In general, it is prescribed to be taken twice a day. While Danocrine 100mg Capsule 30 ‘S can be safely prescribed to adult women suffering from indicated conditions, its use in children is not suggested. Also, women who are pregnant or want to conceive should not use this medicine without consulting a doctor first. Treatment with this medicine can last for longer durations depending on your condition, up to 9 months. The most common side effects of this medication are nausea, headache, and dizziness, hematuria, vaginal dryness, male pattern hair growth. 

Indications

Danocrine 100mg Capsule 30 ‘S is prescribed to adults and children (consult your doctor for children) and it is used in the treatment of autoimmune conditions such as:

  • Endometriosis 
  • Fibrocystic breast disease

  • Breast tenderness 

  • Menorrhagia

  • Hereditary Angioedema

How does Danocrine 100mg Capsule 30 ‘S work?

Danocrine 100mg Capsule 30 ‘S is chemically composed of Danazol that works by subduing the function of the pituitary gland involved in the release of gonadotropins which regulate the function of ovaries and decrease the synthesis of estrogen by ovaries. Another mechanism that is thought to work is the degeneration of extra tissue of endometriosis growing outside the uterus, by atrophy via secretion of certain antibodies IgM, IgA, and IgG. It also influences breast tissues which help with breast conditions.

How to use Danocrine 100mg Capsule 30 ‘S?

Danocrine 100mg Capsule 30 ‘S is available in the form of capsules. Swallow the capsules with a glass of water without chewing, this can be taken with or without food. When starting the treatment, it is started while on your periods, unless advised by the doctor otherwise. Alternatively, ensure the absence of pregnancy by carrying out highly sensitive early pregnancy tests. In general, the treatment with Danocrine 100mg Capsule 30 ‘S is usually prescribed to be taken twice a day, the dose being dependent on weight, age, the severity of the condition, and the patient’s response to the medicine.  If your doctor intends to reduce the dose, it will be brought down gradually just enough to maintain the prevention of menses (amenorrhea).  Treatment with Danocrine 100mg Capsule 30 ‘S is relatively long-term and can last between 6 to 9 months depending on the recovery of the patient. 

Available Potency of Danocrine 100mg Capsule 30 ‘S 

100 mg – Capsules 

200 mg – Capsules

Dosage

Adult Dose

Endometriosis 

Moderate to severe: 800 mg per day in total (400 mg per dose), in divided doses to be taken orally twice a day at 12 hourly intervals 

Mild to moderate: 200 to 400 mg per day in total, in divided doses to be taken orally twice a day at 12 hourly intervals

*Treatment must be initiated while the patient is still having menses, alternatively pregnancy tests must be done to rule out pregnancy

Fibrocystic Breast Disease

The daily dose can vary from 100 to 400 mg to be taken orally twice a day in divided doses 

Treatment and maintenance therapy: 3 to 6 months

Hereditary Angioedema

Daily dose 200 mg to be taken orally twice a day in divided doses 

Gradually reduce the dose by 50% at 1 to 3 months interval 

In case of recurrence of attack, increase the dose back to give 200 mg

Child Dose

Danocrine 100mg Capsule 30 ‘S is not prescribed to children

Elderly dose

Treatment with Danocrine 100mg Capsule 30 ‘S has not been well researched. Safety concerns are valid in this age group. 

Pregnancy use and lactation

Danocrine 100mg Capsule 30 ‘S contains Danazol in its formulation which is classified as pregnancy category X (it carries a high risk to the fetus in studies conducted on animals and lack of data on pregnant humans). This drug should not be prescribed to expecting and lactating mothers due to severe side effects. Contraception is advised if it is being used. Consult a doctor for safety details.

Contraindications

Please inform your doctor if you have a history of any before using Danocrine 100mg Capsule 30 ‘S:

  • Allergic reaction to Danocrine 100mg Capsule 30 ‘S

  • Liver impairment 

  • Kidney inadequacy 

  • History of heart condition

  • Pregnancy 

  • Unexplained/undiagnosed vaginal bleeding 

  • androgen-dependent tumor 

  • Porphyria 

  • Thrombosis/thromboembolism 

Precautions‌ ‌

Please‌ ‌tell‌ ‌your‌ ‌doctor‌ ‌about‌ ‌any‌ ‌of‌ ‌the‌ ‌following‌ ‌conditions‌ ‌before using the ‌Danocrine 100mg Capsule 30 ‘S:‌ ‌

  • A history of allergy to any or similar medicines 

  • In the case of liver disease before starting the treatment with ‌Danocrine 100mg Capsule 30 ‘S check LFTs, which must be monitored during the treatment as well. In case of severe liver inadequacy, this drug is prohibited

  • Compromised kidney function can cause serious side effects. Make sure to monitor the kidney’s performance throughout the treatment

  • Before starting the treatment with  Danocrine 100mg Capsule 30 ‘S rule out pregnancy by conducting sensitive early pregnancy tests. Danocrine 100mg Capsule 30 ‘S should not be taken by pregnant women 

  • Breastfeeding mothers must also avoid this medicine 

  • While using ‌Danocrine 100mg Capsule 30 ‘S strict contraception is advised, modes of non-hormonal contraception must be adopted. Discuss with your doctor 

  • ‌Danocrine 100mg Capsule 30 ‘S can cause a significant increase in lipoprotein levels in the blood which can increase the risk of atherosclerosis and stroke

  • If ‌Danocrine 100mg Capsule 30 ‘S is being used for fibrocystic breast disease, make sure to exclude breast cancer if you have doubts

  • Danocrine 100mg Capsule 30 ‘S is androgenic, monitor closely for signs of androgen-induced effects like weight gain, male pattern hair growth, breast enlargement, etc. few of the symptoms may be irreversible so report to your doctor if you notice any such problems

  • ‌Danocrine 100mg Capsule 30 ‘S can lead to aggregation of symptoms if you suffer from porphyria, in which case it is not advised

  • If you also have diabetes, exercise caution with ‌Danocrine 100mg Capsule 30 ‘S

  • Monitoring of patient should be maintained via regular blood work assessing creatinine, cholesterol, LFTs, CBC, and blood pressure

  • ‌Danocrine 100mg Capsule 30 ‘S can cause cerebral hypertension which may become evident clinically in the form of headache, nausea, and blurred vision. Contact your doctor immediately if you notice these signs 

  • ‌Danocrine 100mg Capsule 30 ‘Scan interfere with some biological markers, always provide a complete list of your current drugs to the laboratory personnel

Interaction with other medications

Certain medications could interact with Danocrine 100mg Capsule 30 ‘S and may increase or decrease its absorption, in which case, your doctor might alter your dosage. A few of these interacting drugs are given below:

  • Carbamazepine 
  • Warfarin 

  • Hypoglycemics like insulin, glimepiride

  • Cyclosporine 

  • Tacrolimus 

  • Statins like simvastatin

  • Lonafarnib 

  • Tinidazole 

  • Estradiol valerate 

  • Ivacaftor 

  • Avapritinib

  • Atogepant

  • Dexamethasone  

  • Hydrocortisone 

Adverse effects

Like most medicines, Danocrine 100mg Capsule 30 ‘S has some side effects which include:

Common Side effects

  • Nausea 

  • Headache 

  • Vomiting  

  • Diarrhea 

  • Dizziness

  • Weight gain 

  • Vaginal dryness 

  • Hypertension 

Rare side effects

  • Anaphylactic reaction 

  • Blurred vision

  • Swollen gums 

  • Male pattern hair growth 

  • Visual disturbances  

  • Acne 

  • Sweating 

  • Paresthesia 

  • Palpitations 

  • Skin rash  

  • Hematuria 

  • Gynecomastia 

  • Hirsutism 

  • Amenorrhea (which may persist for some time even after treatment has ended)

  • Blood cell count abnormalities like leukopenia, erythrocytosis

  • Polycythemia 

  • Irritability 

  • Liver enzyme elevation 

  • Menstrual cycle irregularities 

  • Loss of libido 

LIST OF HOW TO DEAL WITH ADVERSE EFFECTS

  • Feeling or being sick (nausea or vomiting) or diarrhea – Avoid eating rich or spicy food. It might help to take medication after food. If you’re sick, try drinking small, frequent sips of water.

  • Feeling drowsy – If the medication makes you feel drowsy or sleepy, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from a sitting or lying down position to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

  • Headaches – In which case make sure you rest and drink plenty of fluids. Avoid the use of alcohol. Take a prescribed painkiller. Consult your doctor if the headaches last longer than a week or are severe

  • Feeling dizzy (lightheaded) or weak – If the medication makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better, and do not rise too fast or immediately from sitting or lying down to a standing posture. Do not drive or use tools or machinery in case of any of these effects.

  • Skin Rash – Can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. Antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.

  • Blurred vision – This side effect tends to go away on its own if a few days; patients are advised to not operate heavy machinery or drive any motorized vehicles in the meantime. If blurred vision persists, please contact your doctor.

  • Sore throat – Can be eased by adding honey to warm drinks and having oral lozenges, to provide soothing relief to an irritated throat. Ginger tea has been known to decrease inflammation of an irritated throat thus, providing relief.

FAQs

#1. WHAT EXACTLY DOES Danocrine 100mg Capsule 30 ‘S DO?

Danocrine 100mg Capsule 30 ‘S inhibits the pituitary gland involved in the release of gonadotropins which regulate the function of ovaries and decrease the synthesis of estrogen by ovaries. It also helps to reduce the extra tissue of the uterus in endometriosis by atrophy.

#2. HOW LONG DOES IT TAKE FOR Danocrine 100mg Capsule 30 ‘S TO START WORKING?

Danocrine 100mg Capsule 30 ‘S takes some time to show clinical improvement. In about 2 months, the patient starts feeling better but full benefits can be seen in 3 to 4 months or sometimes longer. 

#3. HOW LONG WILL I HAVE TO TAKE Danocrine 100mg Capsule 30 ‘S FOR?

Danocrine 100mg Capsule 30 ‘S is usually prescribed for longer durations which may last from 3 to 6 months depending on your condition and can be extended to 9 months in some cases. 

#4. CAN I STOP TAKING Danocrine 100mg Capsule 30 ‘S?

Do not just stop taking the medicine, make sure to complete your treatment course even if you feel better. Stopping it suddenly may cause exacerbation or return of symptoms. When your doctor intends to stop the drug, he will do so by gradually decreasing the dose just enough to maintain amenorrhea. 

#5. WHAT IF I TAKE TOO MUCH OF Danocrine 100mg Capsule 30 ‘S?

Taking more than required can cause serious damage to the liver, heart, and kidneys. If you have taken too much of the prescribed Danocrine 100mg Capsule 30 ‘S you may experience symptoms of toxicity which will vary depending on the dose ingested, for example, fast pounding, irregular heartbeat, upset stomach, blurred vision, fainting, dizziness, seizures, or life-threatening severe symptoms. Contact your doctor or emergency immediately if you have any of these symptoms. 

#6. WHAT IF I FORGET TO TAKE Danocrine 100mg Capsule 30 ‘S?

Danocrine 100mg Capsule 30 ‘S is taken usually twice a day 12 hours apart, so you can take the missed dose as soon as you remember unless it’s about time until your next dose, in which case you should skip the missed dose. If it helps to remind you, set an alarm, or use a pill organizer or a mobile application so you do not miss any dose. Make sure to complete your course of treatment even if you feel better and think you do not need to take it anymore.

#7. CAN I TAKE Danocrine 100mg Capsule 30 ‘S DURING PREGNANCY OR BREASTFEEDING?

Danocrine 100mg Capsule 30 ‘S has safety concerns for unborn babies and is known to cause serious defects in these babies. If you are pregnant, think you may be pregnant, or are planning to conceive a baby, please consult your doctor before using Danocrine 100mg Capsule 30 ‘S. If you are breastfeeding, please consult your doctor before taking Danocrine 100mg Capsule 30 ‘S. Strict contraception is advised if you are using Danocrine 100mg Capsule 30 ‘S

#8. CAN I DRIVE OR RIDE A BIKE AFTER TAKING Danocrine 100mg Capsule 30 ‘S?

Know how your body handles the medicine. Danocrine 100mg Capsule 30 ‘S can make you dizzy so make sure you know how your body reacts while using ‘product’. Do not drive or use any sharp or heavy machinery until you feel normal again.

#10. HOW SHOULD Danocrine 100mg Capsule 30 ‘S BE STORED?

Store it at room temperature, away from excess heat, direct sunlight, and moisture. Make sure it is not consumed by pets, children, and other people. Dispose of the unused medicine. 

#11. WILL  Danocrine 100mg Capsule 30 ‘S AFFECT MY CONTRACEPTION? 

With Danocrine 100mg Capsule 30 ‘S patients are advised to take nonhormonal contraceptives since Danocrine 100mg Capsule 30 ‘S itself is an androgenic drug and can make contraceptives less effective. Discuss with your doctor the most appropriate contraceptive for you.

#12. FOR HOW LONG WILL I HAVE AMENORRHEA WHEN TAKING Danocrine 100mg Capsule 30 ‘S?

It has been reported that patients will miss menses for some time, but the cycle tends to return to normal within 2 to 3 months after the treatment has ended. In case there is a further delay, consult your doctor regarding this. 

#13. WILL Danocrine 100mg Capsule 30 ‘S  AFFECT MY FERTILITY?

Danocrine 100mg Capsule 30 ‘S can affect the sperm count as per some reports and disturb the menstrual cycle which tends to return in 2 to 3 months after the treatment. However, Danocrine 100mg Capsule 30 ‘S does not treat infertility.