Zampicillin Dry 1gm Injection 5 vial

Description

About

Zampicillin Dry 1gm Injection 5 vial belongs to a class of drugs called “beta-lactam antibacterials/penicillins” whose working action is categorized as broad-spectrum. Zampicillin Dry 1gm Injection 5 vial is used to treat various bacterial infections, such as chest infections (including pneumonia), urinary tract infections, dental abscesses, ear infections, wound infections, septicemia, bone infections, meningitis. Zampicillin Dry 1gm Injection 5 vial is an antibiotic from the penicillin group of medicines that works by preventing the formation of a key component of the bacterial cell wall, essential for the survival of the bacteria. 

Zampicillin Dry 1gm Injection 5 vial is chemically composed of ampicillin. It is effective against a variety of gram-positive and gram-negative infections. Zampicillin Dry 1gm Injection 5 vial works by targeting bacterial cell walls, leading to bacterial cell death. Dosage of Zampicillin Dry 1gm Injection 5 vial depends on age, body weight, the severity of the condition, patient’s response to the medicine, and their comorbidities. 

It is available on prescription in a vial as a dry injection in different potencies to be used as per prescription and can be given to infants, children, and adults alike with dosage-dependent upon body weight and severity of infection. The dry powder in a vial is reassembled by dilution method into an IV solution to be given intravenous infusion or injection or Intramuscularly by a healthcare professional given in the hospital. Zampicillin Dry 1gm Injection 5 vial is the best-prescribed for the treatment of bacterial infections in patients who are not allergic to Zampicillin Dry 1gm Injection 5 vial or penicillin groups of drugs. Common side effects of this medication are nausea, vomiting, diarrhea, fatigue, oral ulcers, thrush, etc.

Indications

It is used in the treatment of:

• Infections of the respiratory tract (nose, throat, larynx, trachea, bronchi, and lungs)
• ENT (eyes, nose, and throat) infections
• Urinary tract infections
• Skin and soft tissue infections.
• Dental infections (dental abscesses – buildup of pus inside teeth and gums)
• Meningitis 
• Prophylaxis of bacterial endocarditis (bacterial infection of the inner layer of the heart or heart valves)
• Septicemia 
• Pelvic infections
• Post-surgical infections
• Wound infections 

How does Zampicillin Dry 1gm Injection 5 vial work

Zampicillin Dry 1gm Injection 5 vial chemically is composed of Ampicillin which belongs to the penicillin group of medicines that works by preventing the formation of a key constituent of the protective bacterial cell wall, peptidoglycan through Penicillin-binding proteins associated with its formation. The cell wall is essential for the survival and growth of the bacteria thereby, preventing its spread.

How to use Zampicillin Dry 1gm Injection 5 vial

Zampicillin Dry 1gm Injection 5 vial is exclusively used to treat bacterial infections, without any impact on other microbes such as viruses, and fungi. It is given intravenously or intramuscular injection in dosage (usually 8 – 12 hourly) depending upon the severity of the infection and kidney function. Zampicillin Dry 1gm Injection 5 vial must not be used without a doctor’s advice to avoid bacterial resistance.

Dosage 

Dosage is completely dependent on the weight, age, severity of infection, patient’s response to the medicine, and their comorbidities. Your doctor may vary your dosage accordingly.

Dosage forms and potencies:

A new, sterile syringe/needle must always be used and properly discarded following universal protocol for sharps disposal. Zampicillin Dry 1gm Injection 5 vial is available in the following potencies:

• 250 grams    IM, IV
• 500 grams    IM, IV
• 1 gram          IV
• 2 grams         IV

Zampicillin Dry 1gm Injection 5 vial is available in dry powder packed in a vial, that needs to be reconstituted first into an injectable solution form by adding the prescribed amount of liquid as given on the label. Zampicillin Dry 1gm Injection 5 vial can be given via Intravenous injection (3-5 minutes) or slow infusion over 15 – 20 minutes. Intramuscular injection can also be administered deep into the muscle. Antibiotics are given in divided doses per day at regular intervals of 6 to 12 hours, generally for 7 to 10 days. IV antibiotics should be administered in a healthcare facility or at home if needed and can also be diluted with other injectable solutions matching the compatibility with Zampicillin Dry 1gm Injection 5 vial other than calcium products, such as sodium chloride solution, ringer’s lactate, etc. A healthcare provider can help you maintain an IV line at home for bed-bound patients. Sometimes caregivers can also be taught the technique of administering antibiotics via cannula, alternatively, the preferred way would be for a visiting nurse to be appointed to give you the medication at home. 

Adult Dosage

Following doses are commonly prescribed to treat an ongoing infection:

• Ear, nose, or throat infections – 250 – 500 mg IV/IM every 6 to 8 hours
• Urinary Tract infections – 1 to 2 g IV infusion OR 1 g IM injection every 6 hours
• Endocarditis Prophylaxis for high-risk patients – 1 to 2 g IV or 1 g IM at least 1 hour before dental procedure followed by 1 g IV after 6 hours of the procedure with or without gentamicin
• Gastrointestinal Infections – 500 mg IV/IM every 6 hours OR 1 to 2 g IV for severe infections
• Bacterial Meningitis – 150 to 200 mg/kg/day intravenously every 6 – 8 hours
• Listeria Infections – 2 g IV every 4 hours
• Septicemia – 150 to 200 mg/kg/day intravenously every 6 – 8 hours

Pediatric Dosage

Zampicillin Dry 1gm Injection 5 vial is prescribed after carefully calculating per patient’s weight and severity of ongoing infection. 

Children weighing below 40 kgs: 25 – 50 mg/kg IV OR IM every 6 to 8 hours in divided doses

Children weighing 40 kgs and above: 250 to 500 mg IV OR IM every 6 hours

Neonates 

Less than 1 week old

Babies weighing less than 2 kgs: 50 to 100 mg/kg IV OR IM every 12 hours in divided doses

Babies weighing more  than 2 kgs: 75 to 100 mg/kg every 8 hours

More than 1 week old

Less than 2 kgs: 50 to 100 mg/kg IV OR IM every 12 hours in divided doses

More than 2 kgs:  75 to 100 mg/kg IV OR IM every 6 to 8 hours in divided doses

Elderly Dosage

Doses must be adjusted keeping in mind comorbidities. Moreover, Zampicillin Dry 1gm Injection 5 vial is excreted mostly by the kidneys, therefore while administering the drug to elderly patients (65 years and above) careful consideration must be given to renal function while deciding upon the dose. 

* NOTE: Doses may vary and can be adjusted if considered appropriate. Given above are doses according to the guidelines generally prescribed to treat infections. Always follow the doses advised by your doctor according to your condition

Pregnancy use and lactation

 Zampicillin Dry 1gm Injection 5 vial is classified as a pregnancy category B drug by FDA (meaning no evidence of any risk to the human fetus in controlled animal trials but insufficient data on humans is available). If you are pregnant, think you may be pregnant, or are planning on conceiving a baby, please consult your doctor before using Zampicillin Dry 1gm Injection 5 vial regarding its safe use.

Zampicillin Dry 1gm Injection 5 vial is also secreted in human milk, if you are breastfeeding, please consult your doctor before taking Zampicillin Dry 1gm Injection 5 vial. 

Contraindications

Please tell your doctor if you have a history of any of the following before using Zampicillin Dry 1gm Injection 5 vial:

• Allergy to Zampicillin Dry 1gm Injection 5 vial or other penicillins
• Kidney impairment
• Severe liver disease
• History of Zampicillin Dry 1gm Injection 5 vial associated or penicillin associated jaundice or hepatic (liver) dysfunction.
• Infectious mononucleosis (glandular fever caused by EBV virus).
• If you have recently had, or are about to have, any vaccinations as it may decrease the effectiveness of the vaccine.
• Hereditary phenylketonuria (The liquid form is not suitable as it may contain aspartame which may be harmful to you)
• Immunizations /live bacterial vaccines such as Typhoid vaccine
• Patients with drug resistance to Penicillins

Precautions

Please tell your doctor about any of the following conditions before using Zampicillin Dry 1gm Injection 5 vial:

• History of allergy to antibiotics and drugs
• Mild to moderate liver impairment
• Mild to moderate kidney impairment
• Conditions such as mononucleosis caused by EBV or leukemia, affecting the lymphoid gland, there is a risk of having toxic reactions in such patients. Report to your doctor if you notice a rash on the skin, pruritis, or any unusual symptom
• Long-term use of Zampicillin Dry 1gm Injection 5 vial can put you at risk of developing inflammation of the intestine (Pseudomembranous colitis). If you experience unusual diarrhea or prolonged diarrhea with Zampicillin Dry 1gm Injection 5 vial, report to your doctor immediately
• There can be a superimposed infection with opportunistic microbes, consult your doctor if you notice an increased or an unusual infection in your body 
• Neonates must be monitored carefully for jaundiced appearance other than physiological jaundice. Zampicillin Dry 1gm Injection 5 vial has the potential to raise blood bilirubin levels
• It is a good approach to regularly monitor kidney, liver, and blood cell function and bilirubin if you are on a long-term prescription with Zampicillin Dry 1gm Injection 5 vial
• In case of moderate to severe infections, avoid getting vaccine shots till you have completed the antibiotic cover to avoid unpleasant results
• Clostridium difficle associated diarrhea can occur with the use of certain antibiotics. Immediately contact tor doctor
• While having lab work done on blood, always tell the laboratory personnel about current drugs that you are taking since it can affect the results, like glucose tests, LFTs, clotting time, etc
• There is a likelihood of developing antibiotic resistance with improper use, make sure you complete the entire course even if you feel better 

Interaction with other medications

Certain medications could interact with Zampicillin Dry 1gm Injection 5 vial, hence, in that case, your doctor might alter your dosage, so please inform your doctor about the use of the following before taking Zampicillin Dry 1gm Injection 5 vial:

• Anticoagulants such as warfarin
• Sulphonamides 
• Acetylsalicylic acid
• Allopurinol and probenecid (used to treat gout)
• Tetracyclines, doxycycline
• Methotrexate (used to treat cancer or rheumatic diseases)
• Other antibiotics
• Vaccines (BCG, Typhoid, cholera)
• Thiazide diuretics 
• Erythromycin 

Adverse effects

Like most medicines, Zampicillin Dry 1gm Injection 5 vial has some side effects which include:

Common Side Effects

• Nausea 
• Diarrhea 
• Abdominal pain
• Skin rash
• Pruritis
• Phlebitis 

Serious Side Effects

• Hypersensitivity/allergic skin reactions
• Hepatitis (inflamed or infected liver)
• Haematological (blood-related) – affects blood cells
• CNS effects
• Pseudomembranous colitis (inflamed large intestine)
• Oral ulcers 
• Agranulocytosis/ hemolytic anemia
• Increased INR 
• Bruising or skin discoloration
• Crystal formation in the skin 
• Glossitis 
• Thrombocytopenia purpura 

How to cope with some of the adverse effects

• Soreness at the site of injection- a cold compress can be used for 5 minutes to ease out the soreness.
• Nausea (feeling sick) – Take Zampicillin Dry 1gm Injection 5 vial with meals to avoid feeling sick.
• Vomiting/Diarrhea – Keep yourself hydrated by having lots of fluids and if the problem persists, consult your doctor before taking any medication for vomiting and diarrhea
• Skin Rash- This can be eased by applying soothing and healing lotions or creams such as calamine lotion/cream. Apply a cold compress to the rash to help reduce itchiness and redness caused by the rash. Antihistamine (prescribed by a doctor) is also recommended as an effective way to combat any skin rash.
• Oral Thrush- Thrush can develop in cases of prolonged antibiotic therapy, consult your doctor if this happens. Usually, patients are advised to swish and spit through their oral cavities with dispersible antifungal tablets or drops/ mouthwash as prescribed by a doctor, at least twice daily after ingesting Zampicillin Dry 1gm Injection 5 vial
• Flatulence- Can be eased by consuming smaller, more frequent meals that don’t trigger your flatulence. Getting a minimum of 30 minutes of daily exercise has shown great results in combating flatulence. 
• Heartburn – can be dealt with by chewing on mint-flavored gum that’ll help neutralize the acid in the body. Standing up straighter, adding ginger to the daily diet, elevating the patient’s upper body, and having licorice supplements has shown to provide relief.

FAQ’s

#1. What Exactly Does Zampicillin Dry 1gm Injection 5 vial Do?

Zampicillin Dry 1gm Injection 5 vial is an antibiotic from the penicillin group of medicines that works by preventing the formation of the protective bacterial wall, essential for the survival of the bacteria, 

#2. How Long Does It Take For Zampicillin Dry 1gm Injection 5 vial To Start Working?

Antibiotics start working almost immediately. It takes around an hour for Zampicillin Dry 1gm Injection 5 vial to start working in your body. However, you will feel symptom relief and show improvement within 1-3 days of taking Zampicillin Dry 1gm Injection 5 vial.

#3. For How Long Will I Have To Take Zampicillin Dry 1gm Injection 5 vial?

The duration for using Zampicillin Dry 1gm Injection 5 vial depends on the type and severity of the infection. You will probably be prescribed to take it for 5-14 days. If you do not feel better after completing your course of medicine, or if you feel worse at any time, contact your doctor.

#4. Can I Stop Taking Zampicillin Dry 1gm Injection 5 vial?

Do not just stop taking the medicine, make sure to complete your treatment course even if you feel better. Stopping it suddenly may cause the bacteria to start multiplying again and the infection could come back. The bacteria could also develop resistance to the antibiotic which will make it ineffective in the future.

#5. Can I Drink Alcohol With Zampicillin Dry 1gm Injection 5 vial?

Consuming alcohol when taking Zampicillin Dry 1gm Injection 5 vial is not known to cause any problems. However, it is a good practice to avoid consuming it simultaneously 

#6. What If I Take Too Much Of Zampicillin Dry 1gm Injection 5 vial?

If you have taken one extra dose of Zampicillin Dry 1gm Injection 5 vial it is unlikely to harm you. Side effects of taking Zampicillin Dry 1gm Injection 5 vial more than the prescribed dose are upset stomach, nausea, vomiting and diarrhea, severe abdominal pain, or increased sweating. Contact your doctor immediately if you have taken 2 or more doses and experience serious symptoms. 

#7. What If I Forget To Take Zampicillin Dry 1gm Injection 5 vial?

In case you miss a dose, take your next dose on time, and do not try making up for the missed dose by doubling it up. If it helps to remind you, set an alarm, mobile phone application, or a pill organizer, so you do not miss any dose. Make sure to complete your course of treatment even if you feel better and think you do not need to take it anymore.

#8. Can I Take Zampicillin Dry 1gm Injection 5 vial During Pregnancy Or Breastfeeding?

It is generally considered safe but if you are pregnant, or are planning to conceive a baby, please consult your doctor before using Zampicillin Dry 1gm Injection 5 vial. If you are breastfeeding, please consult your doctor before taking Zampicillin Dry 1gm Injection 5 vial.

#9. Is It Safe To Use Zampicillin Dry 1gm Injection 5 vial For A Long Term?

Zampicillin Dry 1gm Injection 5 vial is usually generally recommended for 5-14 days, therefore, do not take it for any longer than the prescribed period. 

#10. What If Zampicillin Dry 1gm Injection 5 vial Gives Me Thrush?

At times people develop a fungal infection called thrush after taking a course of antibiotics like Zampicillin Dry 1gm Injection 5 vial. This is because antibiotics kill the normal harmless bacteria that help to protect you against such infections to allow opportunistic microbes to show overgrowth. Antifungal rinses prescribed by the doctor will help treat this

#11. Can I Drive Or Ride A Bike After Taking Zampicillin Dry 1gm Injection 5 vial?

Zampicillin Dry 1gm Injection 5 vial shouldn’t affect your being able to drive or ride a bike. If you experience dizziness kindly avoid such activities

#12. How Should Zampicillin Dry 1gm Injection 5 vial Be Stored?

Keep the medicine tightly closed in the packet it came in. Store it at room temperature, away from excess heat and moisture. Do not freeze the liquid form of the medication. Make sure it is not consumed by pets, children, and other people. Dispose of the unused medicine